DoD Joint Program Committee-2/Military Infectious Diseases Applied Research Award | Apply Online

Opportunity Summary:

The DoD Joint Program Committee-2/Military Infectious Diseases Applied Research Award (FY17 JPC-2/MIDRP ARA) is a Department of Defense funding opportunity aimed at reducing illness and death caused by combat-related or trauma-induced wound infections. The program is focused on applied research that can directly move potential medical solutions closer to use in people. In practical terms, the DoD is looking for projects that help determine which candidate products, technologies, or approaches are most ready to advance toward human testing, especially in the context of military-relevant wounds where infection can rapidly worsen outcomes.

This award is designed to support hypothesis-driven, proof-of-concept, and translational preclinical work rather than exploratory basic science. Proposed efforts can include hypothesis testing and proof-of-concept studies using in vitro and/or in vivo models, as well as refinement of early concepts into more defined solutions to demonstrate technical feasibility. It also supports the evaluation, maturation, and down-selection of candidate products, including drugs, biologics or vaccine constructs, and devices or systems, again using laboratory and animal model testing where appropriate. Another major emphasis is enabling studies needed to reach key regulatory milestones, such as preclinical safety and toxicity work sufficient to support Investigational New Drug (IND) or Investigational Device Exemption (IDE) applications. Taken together, the program is structured to help investigators cross the gap between promising research findings and a development-ready package that could realistically progress into regulated human testing.

While studies may include human subjects, the award cannot be used to run clinical trials. The opportunity uses a specific definition of a clinical trial: any prospective enrollment of human subjects where an intervention (such as a drug, device, biologic, procedure, rehabilitation method, behavioral intervention, or similar) is tested for a measurable outcome related to safety, effectiveness, efficacy, or exploratory endpoints in a way that directly affects the subject. Investigators who want to conduct a clinical trial are directed instead to apply to the separate FY17 JPC-2/MIDRP Clinical Studies Award (W81XWH-17-DMRDP-MID-CSA). This boundary makes it clear that ARA projects should stop short of interventional clinical testing, even though certain human-subject elements that are not clinical trials may be allowable.

Applications are expected to be grounded in strong preliminary or published data that directly supports the proposed work. Competitiveness depends on demonstrating a clear scientific rationale built from a critical analysis of existing literature, along with a well-formulated, testable hypothesis. The program explicitly excludes early-stage fundamental basic research, defined as work aimed primarily at expanding general knowledge without a specific product or process application in view. In other words, the DoD wants proposals that are already pointed toward a tangible solution for wound infection prevention, diagnosis, or treatment and that can credibly show a pathway toward eventual human use.

A notable feature of this mechanism is the Partnering PI Option, which is meant to encourage meaningful collaborations. Under this structure, up to three principal investigators can participate, with one designated as the Initiating PI and the others as Partnering PIs; each PI receives a separate award. The expectation is that the team jointly develops and submits a single, integrated research project, and that each investigator contributes substantial intellectual leadership with complementary expertise. Multidisciplinary and multi-organization partnerships are allowed, but participating organizations must be willing to address intellectual property and materials-related issues early and remove administrative barriers that could slow or prevent successful completion of the project.

From an administrative standpoint, this is a discretionary DoD opportunity administered by DOD-AMRAA under CFDA 12.420, using grant and cooperative agreement instruments. Eligibility is listed as unrestricted (open broadly to entity types, subject to any additional eligibility clarifications in the full announcement). The opportunity was posted December 17, 2015, with an application closing date of May 9, 2016, and it anticipated making around 10 awards. The listed award ceiling is shown as 0 in the provided data, which typically signals that applicants should rely on the full funding announcement for budget limits and program-specific caps rather than the summary field.

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