Opportunity Information: Apply for RFA DK 16 031
Apply for RFA DK 16 031
- The Department of Health and Human Services, National Institutes of Health in the food and nutrition, health sector is offering a public funding opportunity titled "George M. O'Brien Kidney Research Core Centers (P30)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847.
- This funding opportunity was created on Jul 11, 2016.
- Applicants must submit their applications by Nov 14, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The George M. O'Brien Kidney Research Core Centers (P30) funding opportunity (RFA-DK-16-031) is a National Institutes of Health program, administered through the Department of Health and Human Services, that supports centralized research core centers focused on kidney disease. The purpose of these centers is not simply to fund individual research projects, but to build and maintain shared, state-of-the-art technologies, services, and other research resources that can be used by a broad range of investigators working on kidney-related basic science and clinical studies. In practice, the program is designed to strengthen the overall kidney research ecosystem at applicant institutions by making high-end tools and expert support more accessible, efficient, and cost-effective than if each lab tried to build the same capabilities on its own.
A central theme of the program is enabling both basic and clinical kidney research, with an emphasis on understanding human kidney physiology and kidney disorders across humans and experimental models. The FOA highlights four major priorities. First, it aims to attract new scientific expertise into kidney research and support the development of new tools and methods for studying kidney function and disease, whether in human studies, animal models, or other research systems. Second, it explicitly encourages multidisciplinary research, meaning centers are expected to bring together investigators from different fields (for example, nephrology, immunology, genetics, bioengineering, computational biology, pathology, imaging, and epidemiology) to solve problems that are difficult to tackle within a single discipline. Third, the program pushes centers to explore emerging areas that have translational potential, so the infrastructure supported by the award should help move discoveries toward practical clinical relevance, such as improved diagnostics, biomarkers, mechanistic insights that inform therapies, or improved approaches to disease modeling. Fourth, the centers are expected to generate Developmental Research (DR) and Pilot and Feasibility (P&F) studies, which function as seed funding mechanisms to spark innovative, early-stage ideas that can later compete for larger independent grants.
From an applicant standpoint, this is a discretionary grant program using the NIH P30 center mechanism. The eligible applicant pool is broad and includes various levels of government, public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), and tribal entities and organizations, along with other organizations as clarified in the announcement. The opportunity was created on July 11, 2016, with an original closing date of November 14, 2016. The FOA listed an award ceiling of $750,000 and anticipated making about three awards, indicating a relatively selective competition designed to support a small number of well-developed, high-impact centers.
Overall, the O'Brien Kidney Research Core Centers program is best understood as an infrastructure and capacity-building investment: it funds shared cores, advanced technologies, and coordinated resources that elevate the productivity and innovation of many kidney researchers at once. By combining shared technical platforms with interdisciplinary collaboration and structured pilot funding, the program is intended to accelerate discovery and translation in kidney disease research and to expand the community of investigators equipped to work effectively in this space. Additional context on existing O'Brien Kidney Research Core Centers is referenced by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) center programs webpage listed in the announcement.
Frequently Asked Questions (FAQs): George M. O'Brien Kidney Research Core Centers (P30) (RFA-DK-16-031)
What is the George M. O'Brien Kidney Research Core Centers (P30) funding opportunity?
It is a National Institutes of Health (NIH) discretionary grant program that uses the P30 center mechanism to support centralized research core centers focused on kidney disease. The program is administered through the Department of Health and Human Services (HHS).
What is the main purpose of this program?
The program is designed to build and maintain shared, state-of-the-art technologies, services, and other research resources (cores) that can be used by a broad range of investigators conducting kidney-related basic science and clinical studies. The goal is to strengthen the overall kidney research ecosystem at applicant institutions by making advanced tools and expert support more accessible, efficient, and cost-effective than duplicating capabilities across individual labs.
Does this opportunity primarily fund individual research projects?
No. The stated purpose is not simply to fund individual research projects. Instead, it supports centralized infrastructure: shared cores, advanced technologies, coordinated services, and resources that enable many investigators to do better kidney research.
What kinds of research does the program aim to enable?
The program emphasizes enabling both basic and clinical kidney research, with a focus on understanding human kidney physiology and kidney disorders across humans and experimental models.
What are the major priorities highlighted in the funding opportunity?
The FOA highlights four major priorities: (1) attracting new scientific expertise into kidney research and supporting new tools and methods for studying kidney function and disease (in human studies, animal models, or other research systems); (2) encouraging multidisciplinary research across different fields; (3) exploring emerging areas with translational potential so discoveries can move toward clinical relevance; and (4) generating Developmental Research (DR) and Pilot and Feasibility (P&F) studies as seed funding mechanisms for early-stage ideas.
What does "multidisciplinary research" mean in the context of this program?
It means the center is expected to bring together investigators from different fields to address kidney research questions that are difficult to solve within a single discipline. The FOA provides examples such as nephrology, immunology, genetics, bioengineering, computational biology, pathology, imaging, and epidemiology.
What does "translational potential" mean here?
In this program, translational potential refers to infrastructure and research directions that can help move discoveries toward practical clinical relevance. Examples noted include improved diagnostics, biomarkers, mechanistic insights that inform therapies, and improved approaches to disease modeling.
What are Developmental Research (DR) and Pilot and Feasibility (P&F) studies?
They are seed-funding mechanisms that the centers are expected to generate. DR and P&F studies are intended to spark innovative, early-stage ideas that can later compete for larger, independent grant support.
What grant mechanism is used for this opportunity?
The opportunity uses the NIH P30 center mechanism, which is intended to support shared research resources and core facilities rather than individual stand-alone research projects.
Who administers and funds this opportunity?
It is an NIH program administered through the Department of Health and Human Services (HHS). The announcement references the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in the context of existing center programs.
What is the funding opportunity number (FOA) and title?
The FOA is RFA-DK-16-031, titled the George M. O'Brien Kidney Research Core Centers (P30) funding opportunity.
Who is eligible to apply?
The eligible applicant pool is broad and includes various levels of government; public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and other than small businesses); tribal entities and organizations; and other organizations as clarified in the announcement.
Is this opportunity limited to universities and academic medical centers?
No. While institutions of higher education are eligible, the FOA also allows a wide range of applicants, including nonprofits, for-profits, tribal entities, and various levels of government, as described in the eligibility section.
How competitive is this program expected to be?
The FOA anticipated making about three awards, indicating a selective competition intended to support a small number of well-developed, high-impact centers.
What is the maximum award amount (award ceiling) listed in the announcement?
The FOA listed an award ceiling of $750,000.
How many awards were anticipated?
The announcement anticipated making about three awards.
When was this funding opportunity created and when did it close?
The opportunity was created on July 11, 2016, with an original closing date of November 14, 2016.
What does the program fund in practical terms?
In practical terms, it funds shared cores and coordinated resources, including advanced technologies, specialized services, and expert support that multiple investigators can use for kidney-related basic and clinical research. The intent is to improve access to high-end capabilities and reduce duplication across labs.
How does the program strengthen an institution's kidney research ecosystem?
By creating centralized, shared platforms and services that lower barriers to using state-of-the-art tools, increase efficiency, and support many investigators at once, the program aims to elevate productivity and innovation across an institution's kidney research community.
What kinds of investigators are intended to benefit from the supported cores?
The program is intended to benefit a broad range of investigators working on kidney-related basic science and clinical studies, including researchers using human studies and experimental models.
Where can applicants find additional context about existing O'Brien Kidney Research Core Centers?
The announcement references the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) center programs webpage for additional context on existing O'Brien Kidney Research Core Centers.
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