Opportunity Information: Apply for RFA RM 16 023
Apply for RFA RM 16 023
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Innovative Adaptations to Simplify Existing Technologies for Manipulation and Analysis of Glycans (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on Sep 16, 2016.
- Applicants must submit their applications by Nov 28, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Innovative Adaptations to Simplify Existing Technologies for Manipulation and Analysis of Glycans (U01) opportunity (RFA-RM-16-023) is a National Institutes of Health (NIH) Common Fund funding announcement focused on making glycoscience easier to use, cheaper to access, and more practical for mainstream biomedical labs. Its core idea is to lower the technical and cost barriers that keep many researchers from studying glycans (complex carbohydrates and carbohydrate-containing structures) even though glycans play major roles in biology, including cell signaling, immunity, infection, cancer, and many other disease processes. By supporting projects that simplify or adapt existing methods and platforms for glycan manipulation and analysis, the program aims to broaden who can do glycoscience, speed up discovery, and help translate glycan-related findings into biomedical impact.
This is a discretionary, health-related funding opportunity administered by the U.S. Department of Health and Human Services through the NIH, using a cooperative agreement mechanism (U01). A cooperative agreement generally means NIH expects to have substantial involvement during the project, such as coordinating milestones, providing programmatic guidance, and helping align efforts with broader Common Fund goals. The overall program framing is "Accelerating Translation of Glycoscience Integration and Accessibility," which signals an emphasis on practical tools and technology development that can be adopted beyond specialized glycomics laboratories, rather than purely exploratory or narrowly customized solutions.
The main goal is to produce accessible and affordable tools for studying carbohydrate structure and function. In practice, this implies technology improvements that make existing glycan-related workflows simpler, more robust, more standardized, and more user-friendly, so that investigators who do not identify as glycoscientists can still incorporate glycan analysis or glycan manipulation into their biomedical research. The opportunity is explicitly oriented toward enabling the broader biomedical community to analyze glycans and understand how these molecules contribute to health and disease, which positions the funded work as infrastructure-like technology development with downstream translational value across many fields.
Eligibility is broad and includes many types of domestic entities that commonly apply for NIH funding. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where relevant); for-profit organizations other than small businesses; and small businesses. The announcement also references an "Others" category with additional eligibility clarification in the full text, indicating NIH left room for certain additional applicant types subject to the detailed funding announcement language.
From a funding perspective, the award ceiling is listed as $500,000, and NIH expected to make about three awards under this announcement. That combination suggests a relatively selective competition intended to support a small set of projects with enough resources to deliver tangible technology adaptations, validation, and packaging for broader use. The catalog number associated with the program is CFDA 93.310, tying it to NIH’s broader research and development assistance listings.
Key administrative dates show the opportunity was created on September 16, 2016, with an original closing date of November 28, 2016, meaning it was a time-limited solicitation rather than an always-open mechanism. As a Common Fund initiative, it was likely part of a coordinated set of efforts and timelines aimed at producing usable glycoscience-enabling outputs that could be disseminated to the wider research community.
In plain terms, this grant opportunity was designed to help teams take glycan-related technologies that already exist but are hard to use, expensive, or confined to specialists, and re-engineer them so they become easier to adopt in everyday biomedical research settings. The broader intended outcome is to make glycan analysis and glycan-focused experiments more routine, accelerating discoveries about how carbohydrate structures influence biology and disease and helping integrate glycoscience into the standard toolkit of modern biomedical research.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Innovative Adaptations to Simplify Existing Technologies for Manipulation and Analysis of Glycans (U01) and is identified by funding announcement number RFA-RM-16-023.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) funding announcement administered by the U.S. Department of Health and Human Services (HHS), under the NIH Common Fund.
What is the main purpose of this program?
The program aims to make glycoscience (the study and use of glycans, or complex carbohydrates and carbohydrate-containing structures) easier to use, cheaper to access, and more practical for mainstream biomedical laboratories. The goal is to reduce technical and cost barriers so more researchers can incorporate glycan manipulation and glycan analysis into their work.
What are glycans, and why do they matter in biomedical research?
Glycans are complex carbohydrates and carbohydrate-containing structures. The announcement highlights that glycans play major roles in biology, including cell signaling, immunity, infection, cancer, and many other disease processes. Because of this broad relevance, improving access to glycan tools can impact many areas of health and disease research.
What types of projects does this opportunity support?
The focus is on simplifying or adapting existing methods and platforms for glycan manipulation and analysis. In practical terms, it supports improvements that make current glycan-related workflows simpler, more robust, more standardized, more user-friendly, and more affordable for wider adoption beyond specialized glycomics labs.
Does this program fund brand-new technologies or improvements to existing ones?
Based on the description provided, the program emphasizes innovative adaptations to simplify existing technologies for glycan manipulation and analysis, rather than purely exploratory work or narrowly customized solutions.
What is the funding mechanism used for this opportunity?
The funding mechanism is a cooperative agreement (U01).
What does a U01 cooperative agreement imply about NIH involvement?
A cooperative agreement generally means NIH expects to have substantial involvement during the project. Examples noted include coordinating milestones, providing programmatic guidance, and helping align project efforts with broader NIH Common Fund goals.
How does this opportunity fit into the NIH Common Fund priorities?
The opportunity is framed within the broader theme "Accelerating Translation of Glycoscience Integration and Accessibility", signaling an emphasis on practical tool and technology development that can be adopted across the broader biomedical community.
What is the intended outcome or impact of the funded work?
The intended outcome is to produce accessible and affordable tools for studying carbohydrate structure and function, broaden who can do glycoscience, speed up discovery, and help translate glycan-related findings into biomedical impact across many fields.
Who is eligible to apply?
Eligibility is broad and includes many domestic entity types, including:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities / Indian housing authorities
- Nonprofit organizations (501(c)(3) and non-501(c)(3), excluding institutions of higher education where relevant)
- For-profit organizations other than small businesses
- Small businesses
Are there any additional eligible applicant categories?
The announcement references an "Others" category with additional eligibility clarification in the full text, indicating there may be additional applicant types allowed depending on the detailed funding announcement language.
What is the maximum award amount (award ceiling)?
The award ceiling listed for this opportunity is $500,000.
How many awards did NIH expect to make?
NIH expected to make about three awards under this announcement.
What does the combination of a $500,000 ceiling and about three awards suggest?
It suggests a relatively selective competition designed to support a small number of projects with sufficient resources to deliver tangible technology adaptations, validation, and packaging for broader use.
Is this opportunity ongoing or time-limited?
This was a time-limited solicitation. The opportunity was created on September 16, 2016 and had an original closing date of November 28, 2016.
What is the CFDA number associated with this program?
The catalog (CFDA) number associated with the program is 93.310.
What does "discretionary, health-related funding opportunity" mean in this context?
Based on the information provided, it indicates this is a health-focused funding opportunity administered by HHS/NIH, offered through a discretionary program rather than an entitlement-style program.
What kinds of users are these technologies meant to help?
The program is explicitly oriented toward enabling investigators who do not identify as glycoscientists to incorporate glycan analysis or glycan manipulation into everyday biomedical research settings.
What kinds of improvements are emphasized for glycan workflows?
The emphasis is on making workflows simpler, more robust, more standardized, more user-friendly, and more affordable, so that glycoscience tools can be adopted beyond specialized laboratories.
How is "translation" described in this opportunity?
Translation is described in terms of practical tools and technology development that can be broadly adopted, helping move glycan-related findings toward biomedical impact across multiple disease and biology areas.
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