Opportunity Information: Apply for CDC RFA GH11 11520501SUPP16

  • The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Program Expansion Supplement for Planning, Implementation and Evaluation of Comprehensive HIV Prevention Programs in South Africa under PEPFAR" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
  • This funding opportunity was created on Aug 05, 2016.
  • Applicants must submit their applications by Oct 04, 2016 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $3,604,705.00 in funding.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for CDC RFA GH11 11520501SUPP16

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Opportunity Summary:

This funding opportunity is a CDC cooperative agreement supplement under PEPFAR focused on sustaining and expanding comprehensive HIV prevention efforts in South Africa, a country carrying the worlds largest HIV burden. The notice frames the public health context as both urgent and complex: in 2012 South Africa had an estimated 6.4 million adults and children living with HIV, and it also faced one of the heaviest tuberculosis burdens globally, ranking third after India and China. The TB challenge is compounded by rising multidrug-resistant (MDR-TB) and extensively drug-resistant TB, which increases costs, complicates treatment, and places additional strain on an already stretched health system.

The opportunity emphasizes that South Africa has achieved major progress through rapid scale-up of HIV clinical services. By the end of 2014, more than 3,500 public health facilities were providing antiretroviral therapy (ART), reaching over 2.7 million people. Even with this scale-up, the grant description makes clear that the country is at a pivotal point where simply expanding coverage is not enough; continued work is needed to strengthen service delivery, improve quality, and build durable systems capable of supporting prevention, care, and treatment at an even larger scale. A national review of TB and HIV programs in 2013 is cited to reinforce this message: progress is real, but persistent gaps remain in health system capacity and in consistent delivery of high-quality services.

Within that broader context, this specific supplement is designed to provide additional time and funding to the University of Stellenbosch (associated award GH000320) so it can continue implementing the HPTN 071 PopART project (Population Effects of Antiretroviral Therapy to Reduce HIV Transmission). PopART is described as a community-level combination prevention effort that aims to measure how different packages of prevention interventions affect HIV incidence at the population level. In practical terms, the project is centered on community-facing delivery models and implementation approaches, rather than only clinic-based services, and it is intended to generate evidence about which combinations of interventions can most effectively reduce new HIV infections across entire communities.

A key reason for the supplemental funding is not a change in the scientific goals, but a change in operating costs caused by new labor requirements in South Africa. The implementation of the South African Labor Relations Amendment Act of 2014 in March 2015 increased minimum wage payments. As a result, salaries for Community HIV Care Providers (CHiPs) working on PopART had to be raised significantly, and those increases cascaded to the supervisors overseeing CHiPs staff. The supplement is therefore positioned as a necessary adjustment to keep the project fully staffed and functioning as planned despite a higher cost structure, protecting continuity of community-based HIV prevention activities and the integrity of the evaluation.

Administratively, the opportunity is issued by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), Center for Global Health, as a discretionary award using a cooperative agreement mechanism. It is labeled as a program expansion supplement (funding opportunity number CDC RFA GH11 11520501SUPP16; CFDA 93.067). The ceiling amount listed is $3,604,705, with an expectation of a single award, reflecting that it is targeted supplemental support rather than an open competition for multiple new implementers. The posting shows a creation date of August 5, 2016 and an original application closing date of October 4, 2016 (applications due by 11:59 p.m. ET). Eligibility is noted broadly as "Others" with clarification referenced in the full announcement, but the narrative and the single expected award indicate it is intended to support the existing University of Stellenbosch PopART implementation.

Frequently Asked Questions (FAQs)

What is this funding opportunity?

This is a CDC cooperative agreement supplement funded under PEPFAR to sustain and expand comprehensive HIV prevention efforts in South Africa. It is issued by the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), Center for Global Health, as a discretionary award using a cooperative agreement mechanism.

What is the funding opportunity number and CFDA number?

The funding opportunity number is CDC RFA GH11 11520501SUPP16, and the CFDA number listed is 93.067.

Is this a new standalone grant or a supplement to an existing award?

It is a supplement (specifically described as a program expansion supplement) to an existing cooperative agreement award associated with the University of Stellenbosch (associated award GH000320).

Who is the intended recipient of the supplement?

Based on the narrative and the expectation of a single award, the supplement is intended to provide additional time and funding to the University of Stellenbosch to continue implementation of the HPTN 071 PopART project.

How many awards are expected?

The posting indicates an expectation of a single award, consistent with targeted supplemental support rather than an open competition for multiple recipients.

What is the maximum (ceiling) amount of funding listed?

The ceiling amount listed is $3,604,705.

What is the main purpose of this supplemental funding?

The primary purpose is to provide additional time and funds so the PopART project can remain fully staffed and continue operating as planned in the face of higher operating costs, particularly labor costs, in South Africa.

Did the scientific goals of the project change?

No. The description emphasizes that the supplement is not driven by a change in scientific goals, but by a change in operating costs resulting from new labor requirements in South Africa.

What specific cost driver is cited as the reason for the supplement?

The implementation of the South African Labor Relations Amendment Act of 2014 (implemented in March 2015) increased minimum wage payments. This required significant salary increases for Community HIV Care Providers (CHiPs) working on PopART and also increased costs for the supervisors overseeing CHiPs staff.

Who are CHiPs in the context of this opportunity?

CHiPs refers to Community HIV Care Providers working on the PopART project. The supplement highlights that their salaries had to be raised significantly due to new minimum wage requirements, and that these changes affected supervisory staffing costs as well.

What is the HPTN 071 PopART project?

HPTN 071 PopART (Population Effects of Antiretroviral Therapy to Reduce HIV Transmission) is described as a community-level combination prevention effort designed to measure how different packages of prevention interventions affect HIV incidence at the population level.

What does it mean that PopART is a community-level combination prevention effort?

As described, PopART focuses on community-facing delivery models and implementation approaches (not only clinic-based services) and aims to generate evidence on which combinations of prevention interventions can reduce new HIV infections across entire communities.

What outcomes or evidence is the project intended to generate?

The project is intended to measure population-level effects of different prevention intervention packages on HIV incidence, generating evidence about which combinations of interventions most effectively reduce new HIV infections across communities.

Why is South Africa the focus of this opportunity?

The notice frames South Africa as carrying the world’s largest HIV burden. It cites an estimate that in 2012 South Africa had about 6.4 million adults and children living with HIV, underscoring the urgency and scale of the public health context.

How does tuberculosis (TB) factor into the public health context described?

The opportunity highlights that South Africa also faces one of the heaviest TB burdens globally (ranking third after India and China). It notes the TB challenge is compounded by increasing multidrug-resistant (MDR-TB) and extensively drug-resistant TB, which increases costs, complicates treatment, and strains the health system.

What progress does the opportunity cite for HIV services in South Africa?

It cites major progress through rapid scale-up of HIV clinical services. By the end of 2014, more than 3,500 public health facilities were providing antiretroviral therapy (ART), reaching over 2.7 million people.

Why does the opportunity say South Africa is at a pivotal point despite ART scale-up?

The description explains that expanding coverage alone is not enough. Continued work is needed to strengthen service delivery, improve quality, and build durable systems capable of supporting prevention, care, and treatment at even larger scale.

Does the opportunity reference any assessments or reviews of national programs?

Yes. It references a national review of TB and HIV programs in 2013, which is used to reinforce that while progress is real, persistent gaps remain in health system capacity and consistent delivery of high-quality services.

What is the award mechanism and what does it imply?

The mechanism is a cooperative agreement. In general terms, this indicates a substantial level of involvement by the funding agency compared with some other award types; the posting explicitly identifies it as a cooperative agreement mechanism.

Is this opportunity described as discretionary?

Yes. It is described as a discretionary award issued by CDC’s Center for Global Health.

What is the posting (creation) date?

The posting shows a creation date of August 5, 2016.

What was the original application deadline and time zone?

The original application closing date is listed as October 4, 2016, with applications due by 11:59 p.m. ET.

What does the eligibility field say?

Eligibility is noted broadly as "Others," with clarification referenced in the full announcement. However, the narrative and the single expected award indicate this supplement is intended to support the existing University of Stellenbosch PopART implementation rather than recruit multiple new implementers.

Is this opportunity open to multiple new applicants?

The information provided suggests it is not structured as an open competition for multiple new implementers. The expectation of a single award and the stated purpose of supplementing the University of Stellenbosch award indicate targeted supplemental funding for an existing project.

What is the practical reason CDC is providing the supplement now?

The supplement is positioned as a necessary adjustment to maintain continuity of community-based HIV prevention activities and to protect the integrity of the PopART evaluation despite a higher cost structure driven by mandated wage increases.

How does this supplement relate to PEPFAR?

The opportunity is described as a CDC cooperative agreement supplement under PEPFAR, focused on sustaining and expanding comprehensive HIV prevention efforts in South Africa.

What is the relationship between HIV prevention and health system strengthening in this description?

The notice links HIV prevention impact to the strength and quality of service delivery systems. It emphasizes that beyond expanding coverage, ongoing work is needed to improve quality and build durable systems capable of supporting prevention, care, and treatment at larger scale.

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