Opportunity Information: Apply for RFA HD 17 012
Apply for RFA HD 17 012
- The HHS-NIH11 in the health, income security and social services sector is offering a public funding opportunity titled "Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865,.
- This funding opportunity was created on Jun 07, 2016 and posted on Jun 07, 2016.
- Applicants must submit their applications by Aug 17, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R21)" (Funding Opportunity Number RFA HD 17 012) is a discretionary NIH funding announcement released under HHS-NIH. It supports exploratory, early-stage research through the R21 mechanism, with the goal of improving scientific understanding of how HIV and other sexually transmitted infections (STIs) interact in adolescents and young adults, particularly at key mucosal sites where transmission and early infection dynamics are shaped. The central scientific focus is on the adolescent genital and gastrointestinal mucosa, reflecting the reality that HIV risk and acquisition are strongly influenced by mucosal biology, local immune responses, inflammation, and the presence of co-infecting pathogens.
This FOA is oriented toward research that can clarify the biological and immunological mechanisms that link STI co-infection with HIV susceptibility, transmission potential, disease progression, or local tissue-level changes in young people. By emphasizing mucosal compartments in the genital and gastrointestinal tracts, the announcement highlights areas where co-infections may alter epithelial barrier integrity, recruit or activate HIV target cells, change microbiome composition, drive cytokine and chemokine signaling, or otherwise create conditions that increase vulnerability to HIV or complicate management of HIV in those already infected. The adolescent and young adult emphasis signals interest in age-specific factors such as developmental immunology, hormonal influences, maturation of mucosal tissues, and behavioral and epidemiologic patterns that differ from adult cohorts, all of which can affect STI-HIV interactions.
In practical terms, applicants are being invited to propose research projects that generate foundational insights rather than large, definitive clinical trials, consistent with the R21 program's role in enabling innovative, high-impact exploratory work. Projects might involve studying mucosal immune responses in the presence of common STIs, characterizing how co-infections influence HIV shedding or local replication, examining inflammatory signatures in genital or GI tissues, or identifying biomarkers associated with increased acquisition risk in at-risk youth. The purpose is to fill key knowledge gaps that could later inform prevention strategies, diagnostics, microbicides, vaccines, or targeted interventions tailored to adolescents and young adults.
The opportunity lists a maximum award amount (award ceiling) of $200,000, indicating the funding cap for supported projects under this announcement. It was created and posted on June 7, 2016, with an original and current closing date of August 17, 2016, showing it was a time-limited call for proposals rather than an open-ended solicitation. The activity category is "Health, Income Security and Social Services," and the CFDA numbers associated with the opportunity are 93.865, reflecting its placement within NIH/HHS assistance programs.
Eligibility is broad and includes many types of domestic organizations capable of biomedical and public health research. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories as specified); for-profit organizations other than small businesses; and small businesses. An "Others" category is also included with a note to consult additional eligibility guidance in the full announcement, suggesting there may be specific clarifications or conditions for certain applicant types.
Overall, this FOA targets research that can explain, at the tissue and immune-system level, why and how STI co-infections matter for HIV risk and outcomes in adolescents and young adults. The intended impact is to strengthen the scientific base needed to design better prevention and treatment approaches that account for the unique mucosal and developmental context of youth, a population that remains disproportionately affected by STIs and faces continuing HIV vulnerability.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Understanding STI Co-Infection In At Risk and HIV Infected Adolescents and Young Adults (R21)."
What is the funding opportunity number (FOA number)?
The funding opportunity number is RFA HD 17 012.
Which agency is offering this opportunity?
This is a discretionary NIH funding announcement released under HHS-NIH.
What funding mechanism does this opportunity use?
The announcement supports exploratory, early-stage research through the NIH R21 mechanism.
What is the main scientific purpose of this FOA?
The purpose is to improve scientific understanding of how HIV and other sexually transmitted infections (STIs) interact in adolescents and young adults, especially at key mucosal sites that shape transmission and early infection dynamics.
Who is the target population for the research?
The research focus is on adolescents and young adults, including those at risk for HIV and those already HIV infected.
What biological sites or compartments are emphasized?
The central focus is on mucosal compartments in the adolescent genital and gastrointestinal (GI) tracts.
Why does this FOA emphasize mucosal biology?
The FOA highlights that HIV risk and acquisition are strongly influenced by mucosal biology, including local immune responses, inflammation, and the presence of co-infecting pathogens at genital and GI mucosal sites.
What types of scientific questions is this FOA trying to address?
The FOA is oriented toward clarifying biological and immunological mechanisms linking STI co-infection with HIV susceptibility, transmission potential, disease progression, and local tissue-level changes in adolescents and young adults.
What kinds of mechanisms or pathways are specifically mentioned in the description?
Examples described include how co-infections may alter epithelial barrier integrity, recruit or activate HIV target cells, change microbiome composition, drive cytokine and chemokine signaling, or otherwise create conditions that increase vulnerability to HIV or complicate management of HIV in those already infected.
How does the adolescent and young adult focus shape the kinds of projects NIH is seeking?
The description signals interest in age-specific factors such as developmental immunology, hormonal influences, maturation of mucosal tissues, and behavioral and epidemiologic patterns that differ from adult cohorts, all of which can affect STI-HIV interactions.
Is this FOA intended for large clinical trials?
No. It is described as supporting foundational, innovative, early-stage work rather than large, definitive clinical trials, consistent with the R21 program's exploratory role.
What are examples of projects that might fit this opportunity?
Examples mentioned include studies of mucosal immune responses in the presence of common STIs, characterization of how co-infections influence HIV shedding or local replication, examination of inflammatory signatures in genital or GI tissues, and identification of biomarkers associated with increased acquisition risk in at-risk youth.
What is the intended impact of the research supported by this FOA?
The intent is to fill key knowledge gaps that could later inform prevention strategies, diagnostics, microbicides, vaccines, or targeted interventions tailored to adolescents and young adults.
What is the maximum award amount (award ceiling)?
The maximum award amount listed is $200,000.
When was this opportunity created and posted?
It was created and posted on June 7, 2016.
What was the closing date for applications?
The original and current closing date listed is August 17, 2016, indicating it was a time-limited call for proposals.
Is this an open-ended opportunity?
No. The provided information indicates it was time-limited, with a specific closing date of August 17, 2016.
What is the activity category associated with this opportunity?
The activity category is "Health, Income Security and Social Services."
What CFDA number is associated with this opportunity?
The CFDA number associated with the opportunity is 93.865.
Which types of applicants are eligible to apply?
Eligibility is broad and includes many domestic organizations capable of biomedical and public health research, including various government entities, schools and universities, tribal governments and tribal organizations, housing authorities, nonprofits, for-profits (other than small businesses), and small businesses.
Are state and local governments eligible?
Yes. Eligible applicants include state governments; county governments; city or township governments; special district governments; and independent school districts.
Are colleges and universities eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal entities eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and Native American tribal organizations other than federally recognized governments.
Are housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status are included as eligible, with a note that certain nonprofit categories exclude higher education institutions as specified in the eligibility statement provided.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also separately listed as eligible.
What does the "Others" eligibility category mean?
An "Others" category is included with a note to consult additional eligibility guidance in the full announcement, suggesting there may be specific clarifications or conditions for certain applicant types.
What is the overall research theme of the FOA?
The FOA targets research aimed at explaining, at the tissue and immune-system level, why and how STI co-infections matter for HIV risk and outcomes in adolescents and young adults, with particular emphasis on genital and GI mucosal sites.
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| Characterization of the Adolescent Reproductive Transition (R21) Apply for PA 16 315 Funding Number: PA 16 315 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Biophysical and Biomechanical Aspects of Embryonic Development (R01) Apply for PAR 16 325 Funding Number: PAR 16 325 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $500,000 |
| Biophysical and Biomechanical Aspects of Embryonic Development (R21) Apply for PAR 16 324 Funding Number: PAR 16 324 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Limited Competition: Clinical Research Investigator Supplement (CRIS) for the Maternal Fetal Medicine Units (MFMU) Network and the Neonatal Research Network (NRN) (Admin Supp) Apply for PA 16 377 Funding Number: PA 16 377 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Contraception Research Centers Program (U54) Apply for RFA HD 17 013 Funding Number: RFA HD 17 013 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $1,500,000 |
| Coordinating Center for NICHD Population Dynamics Centers Research Infrastructure Program, FY 2017 (R24) Apply for RFA HD 17 022 Funding Number: RFA HD 17 022 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $120,000 |
| NICHD Genomic Clinical Variant Expert Curation Panels (U24) Apply for RFA HD 17 001 Funding Number: RFA HD 17 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $220,000 |
| Child Health Research Career Development Award (CHRCDA) Program (K12) Apply for RFA HD 18 011 Funding Number: RFA HD 18 011 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $425,000 |
| Reproductive Scientist Development Program (RSDP) (K12) Apply for RFA HD 18 007 Funding Number: RFA HD 18 007 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $920,000 |
| Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MRSRCs) (P50) Apply for RFA AR 18 001 Funding Number: RFA AR 18 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $1,000,000 |
| CAPSTONE Centers for Multidisciplinary Research in Child Abuse and Neglect (P50) Apply for RFA HD 18 012 Funding Number: RFA HD 18 012 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $1,200,000 |
| Women's HIV/AIDS Cohort Study (WHCS ) (R01) Apply for RFA HD 18 018 Funding Number: RFA HD 18 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| National Centers for Translational Research in Reproduction and Infertility (NCTRI) (P50 - Clinical Trial Optional) Apply for RFA HD 19 017 Funding Number: RFA HD 19 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $1,200,000 |
| Male and Female Contraceptive Development (R43/R44 Clinical Trial Optional) Apply for RFA HD 19 004 Funding Number: RFA HD 19 004 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $225,000 |
| Safe and Effective Devices for Use In Neonatal, Perinatal and Pediatric Care Settings (R43/R44 Clinical Trial Optional) Apply for RFA HD 19 001 Funding Number: RFA HD 19 001 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $225,000 |
| Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 - Clinical Trial Not Allowed) Apply for RFA HD 19 018 Funding Number: RFA HD 19 018 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Research Infrastructure for Centers Conducting Population Dynamics Science FY 2018 (P2C - Clinical Trial Not Allowed) Apply for RFA HD 19 014 Funding Number: RFA HD 19 014 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Project Grants in Pediatric Rehabilitation (R01 Clinical Trial Optional) Apply for RFA HD 20 005 Funding Number: RFA HD 20 005 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $499,999 |
| Pediatric Critical Care Conferences Initiative (R13 Clinical Trial Not Allowed) Apply for RFA HD 20 012 Funding Number: RFA HD 20 012 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $75,000 |
| Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) (P50) Apply for RFA NS 19 031 Funding Number: RFA NS 19 031 Agency: Department of Health and Human Services, National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $1,000,000 |
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