Opportunity Information: Apply for RFA AG 17 005
Apply for RFA AG 17 005
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Alzheimer's Clinical Trials Consortium (ACTC) (U24)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on Jul 25, 2016.
- Applicants must submit their applications by Feb 02, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $10,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Alzheimer's Clinical Trials Consortium (ACTC) (U24) funding opportunity (RFA-AG-17-005) is a National Institutes of Health cooperative agreement issued by the U.S. Department of Health and Human Services. It is designed to fund the creation of a coordinated, multi-site clinical trials consortium focused on Alzheimer's disease and other age-related dementias. The core purpose is to build and operate the clinical trial infrastructure needed to efficiently run studies of interventions that could prevent Alzheimer's, delay its onset or progression, or treat its symptoms. In other words, the award is aimed less at supporting a single standalone study and more at establishing the long-term platform that can reliably conduct multiple trials over time.
Under this announcement, the ACTC is expected to bring together multiple clinical trial sites and a central set of capabilities for trial coordination and management. That typically means having the operational backbone required to design and launch trials quickly, manage study conduct consistently across sites, and ensure high-quality data collection and oversight. The FOA emphasizes that the consortium should be capable of supporting trials in Alzheimer's disease and related dementias, reflecting the broader landscape of cognitive aging disorders beyond Alzheimer's alone. A key structural point is that this FOA is for the consortium infrastructure itself; a separate NIH funding opportunity would be used to solicit the actual clinical trial applications that the ACTC would then manage and support. This separation signals that the consortium is intended to function as a standing, ready-to-deploy network rather than a one-off project tied to a single intervention.
The mechanism is a cooperative agreement (U24), which generally implies substantial federal involvement compared to a standard research grant. In practical terms, this often means the NIH expects to collaborate closely with the awardee on planning, governance, performance expectations, and major scientific or operational decisions. The activity area is health (CFDA 93.866), and the opportunity is listed as discretionary funding, consistent with NIH research infrastructure and programmatic awards.
Eligibility is broad and includes many types of U.S.-based organizations that could credibly host or manage a national consortium. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; and small businesses. The FOA also notes an "Others" eligibility category with additional clarification in the full announcement text, which typically covers specialized entities or circumstances not neatly captured by standard categories.
In terms of scale and competition, the announcement anticipated a single award (ExpectedAwards: 1), indicating that NIH intended to fund one primary consortium awardee responsible for organizing and operating the network. The award ceiling was listed at $10,000,000, suggesting support at a level consistent with building and sustaining major, multi-site clinical trial infrastructure. The FOA was created July 25, 2016, with an original application closing date of February 2, 2017, placing it in a specific historical funding cycle while still providing a clear example of how NIH structures large-scale consortium-based clinical trials programs in Alzheimer's research.
FAQs: Alzheimer's Clinical Trials Consortium (ACTC) (U24) - RFA-AG-17-005
What is the ACTC (U24) funding opportunity (RFA-AG-17-005)?
RFA-AG-17-005 is a National Institutes of Health (NIH) cooperative agreement funding opportunity issued by the U.S. Department of Health and Human Services. It is intended to support the creation of the Alzheimer's Clinical Trials Consortium (ACTC) as a coordinated, multi-site clinical trials consortium focused on Alzheimer's disease and other age-related dementias.
What is the main purpose of this award?
The primary purpose is to build and operate the clinical trial infrastructure needed to efficiently run multiple studies over time. The emphasis is on establishing a long-term platform that can conduct trials of interventions that could prevent Alzheimer's disease, delay its onset or progression, or treat symptoms, rather than funding a single standalone clinical trial.
Is this funding for a single clinical trial?
No. This opportunity is focused on consortium infrastructure. The announcement indicates that a separate NIH funding opportunity would be used to solicit the actual clinical trial applications, which the ACTC would then manage and support.
What kinds of activities is the consortium expected to support?
The consortium is expected to support the operational backbone required to design and launch trials quickly, manage study conduct consistently across multiple sites, and ensure high-quality data collection and oversight for studies in Alzheimer's disease and related dementias.
Why does the FOA emphasize infrastructure rather than trial-specific awards?
The structure described in the announcement is designed to create a standing, ready-to-deploy network that can reliably conduct multiple trials over time. By separating infrastructure funding from trial-specific solicitations, the consortium can function as a stable platform for future studies.
What does "multi-site clinical trials consortium" mean in this context?
It means bringing together multiple clinical trial sites and a central set of capabilities for trial coordination and management. The ACTC would serve as a coordinated network rather than a single institution running trials independently.
What diseases or conditions are included under the ACTC scope?
The consortium is intended to support trials in Alzheimer's disease and other age-related dementias, reflecting a broader focus on cognitive aging disorders beyond Alzheimer's alone.
What is the funding mechanism for this opportunity?
The mechanism is a cooperative agreement (U24). This generally implies substantial federal involvement compared to a standard research grant, with NIH expecting to collaborate closely with the awardee on planning, governance, performance expectations, and major scientific or operational decisions.
Who issues this funding opportunity?
The opportunity is a National Institutes of Health cooperative agreement issued by the U.S. Department of Health and Human Services.
What is CFDA 93.866 and how does it relate to this opportunity?
The activity area is listed as health under CFDA 93.866. In the context provided, this places the opportunity within NIH's health-related research and infrastructure funding portfolio.
Is this considered discretionary funding?
Yes. The opportunity is listed as discretionary funding, consistent with NIH research infrastructure and programmatic awards.
How many awards were expected under this announcement?
The announcement anticipated a single award (ExpectedAwards: 1), meaning NIH intended to fund one primary consortium awardee responsible for organizing and operating the network.
What was the maximum funding amount listed for the award?
The award ceiling was listed at $10,000,000, reflecting the scale typically required to build and sustain major, multi-site clinical trial infrastructure.
What types of organizations were eligible to apply?
Eligibility was broad and included many U.S.-based organization types, including state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; and small businesses.
Are universities and colleges eligible applicants?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are included in the listed eligibility categories.
Can nonprofits apply, and does 501(c)(3) status matter?
Nonprofits with and without 501(c)(3) status are included as eligible applicants, with the note that institutions of higher education are excluded from those nonprofit categories as stated in the opportunity summary.
Can for-profit organizations apply?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
What does the "Others" eligibility category mean?
The FOA notes an "Others" eligibility category with additional clarification in the full announcement text. Based on the summary provided, this typically covers specialized entities or circumstances not neatly captured by the standard categories.
When was this FOA created and when did applications close?
The FOA was created on July 25, 2016, and the original application closing date was February 2, 2017. This places the opportunity within a specific historical funding cycle.
What does NIH involvement look like under a U24 cooperative agreement?
In practical terms, the summary indicates that NIH expects close collaboration with the awardee on planning, governance, performance expectations, and major scientific or operational decisions. This reflects the "substantial federal involvement" typical of cooperative agreements compared to standard research grants.
What is the practical outcome NIH is trying to achieve with this consortium?
The goal is to create a coordinated infrastructure that can efficiently and consistently run multiple clinical trials across sites, enabling studies of interventions aimed at preventing Alzheimer's disease, delaying onset or progression, or treating symptoms, and also addressing related dementias.
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