Opportunity Information: Apply for RFA HG 10 004
Apply for RFA HG 10 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "A Centralized Protein Sequence and Function Resource (U41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Feb 17, 2010 and posted on Feb 17, 2010.
- Applicants must submit their applications by May 12, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Public and State controlled institutions of higher education County governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
This funding opportunity, RFA HG 10 004, is a National Institutes of Health (NIH) cooperative agreement (U41) focused on supporting one centralized, authoritative protein sequence and function resource. The goal is to fund an organization that can operate as a major repository of curated protein sequences and deliver consistently high-quality functional annotation, meaning it would not just store sequences but also add expert-reviewed information about what those proteins do. The program is jointly issued by the National Human Genome Research Institute (NHGRI) and the National Institute of General Medical Sciences (NIGMS), reflecting a shared interest in maintaining a reliable, widely used knowledgebase that underpins genomics and broader biomedical research.
The award mechanism is a U41, which is a cooperative agreement rather than a traditional grant. In practical terms, that generally indicates substantial NIH involvement during the project period, with NIH program staff likely collaborating on priorities, expectations, and ongoing oversight. The opportunity is structured to fund a single award, essentially selecting one lead resource to serve the community in this capacity rather than distributing funds across multiple smaller projects.
Funding was projected at about $6.0 million total in fiscal year 2010 to support that single award. The opportunity was posted February 17, 2010, with an application closing date of May 12, 2010, and it was archived June 12, 2010. The CFDA listing is 93.172 (Human Genome Research). There is no cost sharing or matching requirement, so applicants were not expected to provide mandatory matching funds as a condition of eligibility.
Eligibility is broad and includes many types of U.S. public and private institutions and governments, such as public and state-controlled institutions of higher education, private institutions of higher education, state governments, county governments, city or township governments, special district governments, federally recognized tribal governments, and tribal organizations other than federally recognized tribal governments. It also includes nonprofit organizations with and without 501(c)(3) status (as described), and for-profit organizations other than small businesses. The eligibility language also explicitly includes several categories of institutions and entities that NIH often highlights for inclusivity and capacity building, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, eligible agencies of the federal government, and non-U.S. (foreign) organizations.
Operationally, the central expectation is that the funded group would function as a community-facing infrastructure project: maintaining a curated protein sequence repository and providing dependable functional annotation at scale. While the short description does not spell out technical requirements, the intent is clearly to sustain a trusted reference resource that researchers can use for interpreting protein sequences and understanding protein function, which is foundational for genomics, molecular biology, and translational research that depends on accurate protein knowledge.
For applicants or readers seeking the full set of requirements, deliverables, cooperative agreement terms, and review criteria, the announcement points to the NIH Grants Guide link (http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-10-004.html). For technical issues accessing the notice, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs) - NIH RFA HG-10-004 (U41)
What is this funding opportunity?
This opportunity is NIH Request for Applications (RFA) HG-10-004, a cooperative agreement (U41) to support one centralized, authoritative protein sequence and function resource.
What is the main goal of RFA HG-10-004?
The goal is to fund a single organization to operate as a major, community-facing repository of curated protein sequences and to provide consistently high-quality functional annotation. In other words, the funded resource is expected to store protein sequences and also add expert-reviewed information about what those proteins do.
Which NIH institutes are issuing this opportunity?
The program is jointly issued by the National Human Genome Research Institute (NHGRI) and the National Institute of General Medical Sciences (NIGMS).
Why is it issued jointly by NHGRI and NIGMS?
The joint issuance reflects a shared interest in maintaining a reliable, widely used knowledgebase that underpins genomics and broader biomedical research.
What award mechanism is used?
The award mechanism is a U41 cooperative agreement.
What does "cooperative agreement (U41)" mean in practice?
Because this is a cooperative agreement rather than a traditional grant, the expectation is that there will be substantial NIH involvement during the project period. NIH program staff are likely to collaborate on priorities and expectations and to provide ongoing oversight.
How many awards were expected to be made?
The opportunity is structured to fund a single award, selecting one lead resource to serve the research community in this role.
How much funding was available?
Funding was projected at about $6.0 million total in fiscal year 2010 to support the single award.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants were not expected to provide mandatory matching funds as a condition of eligibility.
What is the CFDA number for this opportunity?
The CFDA listing is 93.172 (Human Genome Research).
When was the opportunity posted?
It was posted on February 17, 2010.
What was the application closing date?
The application closing date was May 12, 2010.
What does it mean that the opportunity was archived?
The announcement indicates it was archived on June 12, 2010.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. public and private institutions and governments, as well as certain non-U.S. entities. Examples listed include:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- State governments
- County governments
- City or township governments
- Special district governments
- Federally recognized tribal governments
- Tribal organizations other than federally recognized tribal governments
- Nonprofit organizations with and without 501(c)(3) status (as described)
- For-profit organizations other than small businesses
- Eligible agencies of the federal government
- Non-U.S. (foreign) organizations
Are specific institution types explicitly included?
Yes. The eligibility language explicitly includes several categories NIH often highlights, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
What kind of work is the funded organization expected to do?
The central expectation is that the funded group will function as a community-facing infrastructure project by maintaining a curated protein sequence repository and providing dependable functional annotation at scale.
Is this just a data storage project?
No. The description emphasizes that the resource should not only store protein sequences, but also deliver consistently high-quality functional annotation, meaning expert-reviewed information about protein function.
What does "centralized, authoritative" imply for the resource?
Based on the description, it implies NIH intended to support a single, trusted reference resource that researchers can rely on for interpreting protein sequences and understanding protein function.
Are technical requirements and specific deliverables described here?
The short description does not spell out technical requirements. It indicates the intent to sustain a trusted reference resource, but directs applicants to the full announcement for requirements, deliverables, cooperative agreement terms, and review criteria.
Where can applicants find the full funding announcement and detailed requirements?
The announcement points to the NIH Grants Guide link: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-10-004.html
Who should be contacted for technical issues accessing the notice?
For technical issues accessing the notice, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What research areas does this resource support?
The description frames the resource as foundational for genomics, molecular biology, and translational research that depends on accurate protein knowledge.
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