A GenitoUrinary Development Molecular Anatomy Project (GUDMAP) (U01) | Apply Online

Opportunity Summary:

A GenitoUrinary Development Molecular Anatomy Project (GUDMAP) (U01) is an NIH grant opportunity from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) aimed at filling major knowledge gaps in the existing GUDMAP molecular anatomy atlas. The GUDMAP consortium has already built a valuable, widely used molecular atlas for the developing mouse kidney, and that resource has helped many researchers study how kidneys form, how they respond to injury, and how they might be repaired or regenerated. Even with that progress, the atlas still lacks detailed molecular coverage in several closely related parts of the urinary system, especially the lower urinary tract and the supporting nerve and blood vessel networks that integrate with these organs during development. This funding opportunity is essentially a targeted push to broaden and complete the atlas so it better represents the full genitourinary developmental landscape, not just the kidney.

The projects sought under this announcement focus on defining the molecular anatomy of the developing murine (mouse) lower urinary tract, including structures like the ureter, bladder, urethra, sphincter, and prostate. In addition to mapping these organs themselves, NIDDK is explicitly interested in proposals that characterize the developing innervation and vasculature associated with lower urinary tract organs. In practical terms, that means applications are expected to generate detailed molecular and anatomical data describing which genes and markers are expressed, where they are expressed, and how tissues and cell populations are organized and change over developmental time. Because this work is described as part of a continuing GUDMAP effort, applicants should expect that their data and outputs would be designed to integrate with existing GUDMAP standards, formats, and community resources so the resulting atlas additions are comparable, interoperable, and broadly usable by other investigators.

The award mechanism is a Cooperative Agreement Research Project (U01), which generally indicates a more collaborative relationship with NIH than a typical investigator-initiated research grant. In a cooperative agreement, NIH staff often have substantial programmatic involvement, and the funded projects typically coordinate with a larger consortium or network to align goals, methods, data sharing practices, and timelines. Here, that consortium context is central: the funded studies are not meant to be isolated stand-alone mapping efforts, but rather coordinated contributions that help expand the shared GUDMAP atlas.

Administratively, this opportunity was published under Funding Opportunity Number RFA-DK-11-001 and is categorized as discretionary funding using the cooperative agreement instrument. The total estimated funding listed is $1,000,000, with an award ceiling of $100,000. No cost sharing or matching is required. The opportunity was posted on January 27, 2011, with an original and final application closing date of April 7, 2011, and an archive date of May 8, 2011, meaning it is a past (archived) funding announcement rather than an open, currently accepting competition.

Eligibility is broad and includes many types of organizations. Eligible applicants listed include public and private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), small businesses, for-profit organizations other than small businesses, and a variety of government entities such as state governments, county governments, city or township governments, independent school districts, special district governments, and public housing authorities or Indian housing authorities. The eligibility language also explicitly notes participation from a wide range of mission-serving and community-based institutions, including historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, federally recognized and other tribal governments and organizations, U.S. territories or possessions, regional organizations, and faith-based or community-based organizations, as well as eligible federal agencies. The bottom line is that the announcement was designed to cast a wide net for capable groups who could contribute high-quality developmental molecular anatomy data within the GUDMAP framework.

For further details, the full announcement was hosted on the NIH grants site at the link provided in the notice (grants.nih.gov). Contact information in the listing primarily addresses technical difficulties accessing the announcement, directing users to the NIH Office of Extramural Research (OER) webmaster email.

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