Academic Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01) | Apply Online

Opportunity Summary:

This grant opportunity, titled Academic Industrial Partnerships for Translation of in vivo Imaging Systems for Cancer Investigations (R01) (PAR-10-169), is a National Cancer Institute (NCI) program under the National Institutes of Health (NIH) designed to push promising in vivo cancer imaging technologies from the development stage into real-world research and clinical settings. The core idea is to speed up translation by requiring true academic-industry collaboration, bringing together the strengths of universities (scientific discovery, clinical access, rigorous evaluation) and companies (engineering, manufacturing know-how, regulatory experience, product-focused development) to solve specific, well-defined cancer imaging problems.

The program focuses on in vivo imaging, image-guided technologies, and spectroscopic systems or methods, and it allows work spanning either animal (preclinical) or human (clinical) applications. The expectation is that the proposed technology is not just an interesting concept, but something that can be engineered, optimized, validated, and demonstrated as useful for cancer research, clinical trials, and/or clinical practice. Projects are meant to be mission-driven: applicants should choose a targeted cancer problem and propose a coherent development-and-translation strategy aimed at delivering a working solution within the project period.

A key requirement is that each application must be built around an interdisciplinary, multi-institutional partnership, structured as a strategic alliance rather than a loose collaboration. Every partnership must include at least one lead academic organization and at least one lead industrial organization, and the industrial partner can be either a small business or a larger company. The team is expected to integrate multiple areas of expertise (for example, imaging physics, device engineering, software, oncology, pathology, radiology, clinical trial operations, biostatistics, and regulatory planning) to move the imaging system or method toward practical deployment and broad utility.

The FOA explicitly supports studies that optimize and validate imaging performance, and it allows clinical trials when those trials are primarily aimed at demonstrating and validating how well the imaging system, device, agent, and/or method performs. In other words, the clinical work should be centered on technical and clinical performance evaluation (such as image quality, sensitivity/specificity, reproducibility, robustness across sites, workflow feasibility, and other validation endpoints) rather than being a large-scale efficacy trial of a therapeutic intervention. For both preclinical and clinical efforts, the announcement permits requesting funds for a limited number of additional prototype copies when that is necessary to optimize and validate the system across different platforms or research sites, including multi-site studies. At the same time, the announcement draws a bright line against commercial production; the intent is translation and validation, not scaling up manufacturing for sales.

Funding is provided through the NIH Research Project Grant (R01) mechanism, which generally supports substantial, multi-year research programs and is commonly used for projects requiring coordinated technical and biological/clinical work. The project horizon emphasized in the announcement is a five-year window, with partnerships encouraged to plan their work so that the targeted cancer imaging problem can be meaningfully addressed within that timeframe. Like many NIH opportunities, the number of awards depends on available funds and the quality and volume of applications received, rather than a guaranteed award count.

Eligibility is broad and includes a range of organization types: public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), for-profit organizations (including companies other than small businesses), and small businesses. The opportunity also lists several institution types explicitly as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and even non-U.S. (foreign) organizations. There is no cost sharing or matching requirement stated for this FOA, which means applicants are not required to provide a defined level of non-federal funds as a condition of the award.

Administratively, this is a discretionary grant program managed by NIH/NCI, associated with cancer-related CFDA areas covering detection and diagnosis research, treatment research, and biology research (93.394, 93.395, 93.396). The posting date listed is April 16, 2010, and the opportunity is archived, with the included closing dates reflecting the historical submission window. The full announcement was hosted on the NIH grants page referenced in the additional information link, and NIH’s Office of Extramural Research (OER) webmaster contact is provided for access or linking issues.

Overall, this FOA is best understood as a translation-focused imaging technology program where success is defined by a well-organized academic-industry team delivering a validated imaging or image-guided solution to a specific cancer problem, demonstrated through rigorous optimization and testing (including, when appropriate, performance-focused clinical trials), and positioned for meaningful impact in preclinical research, clinical studies, and eventual clinical practice without directly funding commercial-scale production.

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