Opportunity Information: Apply for PA 16 097
Apply for PA 16 097
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Accelerating Research on Intervertebral Disc (ARID) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846.
- This funding opportunity was created on Feb 11, 2016 and posted on Feb 11, 2016.
- Applicants must submit their applications by Feb 05, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Accelerating Research on Intervertebral Disc (ARID) (R01) opportunity (Funding Opportunity Number PA-16-097) is a discretionary NIH grant program issued by the U.S. Department of Health and Human Services, National Institutes of Health (NIH), specifically under the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). It uses the R01 research project grant mechanism, which is NIH's standard award type for supporting investigator-initiated, hypothesis-driven research projects. The central aim of the announcement is to speed up progress in understanding the basic biology of the intervertebral disc, with a strong emphasis on research that can open up new directions for explaining why discs degenerate and how that degeneration unfolds.
The FOA is targeted at basic and foundational research rather than late-stage clinical translation, and it is framed to attract a broad range of scientific perspectives. NIAMS explicitly invites investigators from cell biology, bioengineering, and orthopaedic research, and it encourages both individual and collaborative applications. In practical terms, that means proposals could come from a single lab focused on disc cell biology, a bioengineering group developing new experimental platforms to model disc mechanics and nutrition, or a multi-investigator team combining biology, engineering, and computational approaches to tackle disc degeneration from multiple angles. Applications are particularly encouraged when they promise to accelerate the field's understanding of intervertebral disc biology or when they propose genuinely new ways to study the drivers of disc degeneration, including the biological and biomechanical factors that set degeneration in motion or worsen it over time.
Eligibility is broad and includes many common U.S. research and public-sector institutions as well as some private entities. Eligible applicants listed in the announcement include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education when specified); for-profit organizations other than small businesses; small businesses; and other applicants as permitted by the additional eligibility guidance referenced in the FOA. This broad eligibility signals that NIAMS is open to proposals from universities, research institutes, hospitals, nonprofits, and certain commercial or translational entities, as long as the proposed work fits the basic research focus and meets NIH grant requirements.
From an administrative standpoint, the opportunity was posted on February 11, 2016, with the same date listed as the creation date, and it carried an original and current closing date of February 5, 2019. The funding activity category is Health, and the relevant CFDA number provided is 93.846, which corresponds to NIAMS programs. The source information provided does not specify an award ceiling or an expected number of awards, which typically means applicants would need to consult the full FOA text and NIH budgeting policies to understand practical funding limits, project period expectations, and institute-specific considerations.
Overall, ARID (R01) is best understood as a NIAMS-led push to strengthen the scientific foundation of intervertebral disc research. It seeks proposals that clarify core disc biology, uncover mechanisms contributing to disc degeneration, and create or apply innovative approaches that move the field forward. The intent is not simply incremental progress, but work that meaningfully accelerates knowledge generation in disc biology and sets the stage for future advances in preventing, diagnosing, or ultimately treating disc degeneration.
Frequently Asked Questions (FAQs): Accelerating Research on Intervertebral Disc (ARID) (R01)
What is the ARID (R01) funding opportunity?
ARID stands for Accelerating Research on Intervertebral Disc. It is an NIH discretionary grant opportunity that uses the R01 Research Project Grant mechanism to support investigator-initiated, hypothesis-driven research projects focused on intervertebral disc biology and degeneration.
What is the Funding Opportunity Number for this program?
The Funding Opportunity Number is PA-16-097.
Which federal agency and NIH institute issue this opportunity?
This opportunity is issued by the U.S. Department of Health and Human Services, National Institutes of Health (NIH), through the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
What type of grant mechanism does this opportunity use?
It uses the NIH R01 mechanism, which is NIH's standard award type for supporting investigator-initiated research projects.
What is the central aim of the ARID (R01) announcement?
The central aim is to speed up progress in understanding the basic biology of the intervertebral disc, with emphasis on research that can open new directions for explaining why discs degenerate and how degeneration unfolds over time.
Is this opportunity focused on basic research or clinical translation?
It is targeted at basic and foundational research rather than late-stage clinical translation.
What kinds of research topics are especially encouraged?
Applications are particularly encouraged if they are likely to accelerate the field's understanding of intervertebral disc biology or propose genuinely new ways to study the drivers of disc degeneration, including biological and biomechanical factors that initiate degeneration or worsen it over time.
What scientific perspectives does NIAMS want to attract?
NIAMS frames the opportunity to attract a broad range of perspectives, explicitly inviting investigators from areas such as cell biology, bioengineering, and orthopaedic research.
Are collaborative applications allowed, or is this only for individual labs?
Both are encouraged. The opportunity welcomes individual applications (for example, a single lab focused on disc cell biology) and collaborative or multi-investigator applications (for example, teams combining biology, engineering, and computational approaches).
What are examples of the kinds of projects that could fit this FOA?
Based on the description, projects could include basic disc cell biology studies, bioengineering efforts to create experimental platforms to model disc mechanics and nutrition, or interdisciplinary approaches that combine biological, biomechanical, and computational methods to study disc degeneration mechanisms.
Who is eligible to apply?
Eligibility is broad and includes many U.S. research, public-sector, nonprofit, and private entities, as well as certain tribal organizations and housing authorities, consistent with NIH grant requirements and any additional eligibility guidance referenced in the FOA.
Are universities eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are government entities eligible to apply?
Yes. Eligible applicants include state governments, county governments, and city or township governments, as well as special district governments and independent school districts.
Are tribal entities eligible to apply?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are listed as eligible applicants.
Are nonprofits eligible to apply?
Yes. Nonprofit organizations with or without 501(c)(3) status are listed as eligible applicants (with the caveat in the description about institutions of higher education when specified).
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses, as well as small businesses, are listed as eligible applicants.
Are hospitals and research institutes eligible?
The description indicates NIAMS is open to proposals from universities, research institutes, hospitals, nonprofits, and certain commercial entities, as long as the proposed work fits the basic research focus and meets NIH grant requirements.
What is the funding activity category?
The funding activity category is Health.
What CFDA number is associated with this opportunity?
The CFDA number provided is 93.846, which corresponds to NIAMS programs.
When was this opportunity posted?
It was posted on February 11, 2016, and the creation date is also listed as February 11, 2016.
What was the closing date for this opportunity?
The original and current closing date listed is February 5, 2019.
Does the provided information include an award ceiling or the expected number of awards?
No. The source information provided does not specify an award ceiling or an expected number of awards.
If an award ceiling and number of awards are not specified here, what does that imply?
It typically implies that an applicant would need to consult the full FOA text and NIH budgeting policies to understand practical funding limits, project period expectations, and institute-specific considerations.
What is NIAMS trying to achieve overall with ARID (R01)?
Overall, ARID (R01) is described as a NIAMS-led effort to strengthen the scientific foundation of intervertebral disc research by clarifying core disc biology, uncovering mechanisms contributing to disc degeneration, and creating or applying innovative approaches that move the field forward.
Is the goal incremental progress or more transformative advances?
The intent is not simply incremental progress. The announcement emphasizes work that meaningfully accelerates knowledge generation in disc biology and helps set the stage for future advances in preventing, diagnosing, or ultimately treating disc degeneration.
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