Opportunity Information: Apply for RFA RM 11 015
Apply for RFA RM 11 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Accelerating the Integration and Translation of Technologies to Characterize Biological Processes at the Single Cell Level (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Nov 23, 2011 and posted on Nov 23, 2011.
- Applicants must submit their applications by Jan 23, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Private institutions of higher education State governments For profit organizations other than small businesses City or township governments Small businesses Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH Funding Opportunity Announcement "Accelerating the Integration and Translation of Technologies to Characterize Biological Processes at the Single Cell Level (R01)" (Funding Opportunity Number RFA-RM-11-015) is a discretionary grant program supported by the NIH Common Fund. Its central goal is to push promising single-cell analysis technologies beyond the early prototype stage and into practical, broadly usable tools. Rather than emphasizing invention for its own sake, the FOA is aimed at the downstream work that often determines whether a technology actually becomes reliable in real-world research and clinical environments: engineering refinement, integration of components into an end-to-end workflow, rigorous performance testing, and validation so the method is robust, well characterized, and ready for adoption by other laboratories.
A key theme of the opportunity is translation into practice. Proposed projects are expected to take technologies that already show strong promise and perform the development steps that remove barriers to routine use, such as improving reproducibility, throughput, sensitivity, specificity, and ease of operation. The FOA highlights the need for tools that can reveal and measure cell-to-cell heterogeneity, which is essential for understanding complex biological processes where averaging across many cells can hide important subpopulations or transient cellular states. The technologies supported under this program should be positioned to transform understanding across a wide range of biological contexts, including both research and clinical settings, and should not be narrowly limited to a single highly specific sample type. In other words, the program is looking for approaches that can be applied to multiple types of cell populations and deliver clear advantages to end users.
The announcement places strong emphasis on multidisciplinary, integrative, and quantitative development. Competitive applications are expected to bring together teams with complementary expertise (for example, engineering, quantitative biology, computational analysis, and domain biology or clinical knowledge) and to use quantitative benchmarks to guide progress. This is not an open-ended exploration; applicants are expected to define clear goal(s) and include intermediate, measurable milestones that can demonstrate stepwise progress toward a validated tool. The overall intent is to fund projects that can credibly deliver a technology that others can pick up and use, with performance characteristics that are well documented and convincing.
From an administrative standpoint, this is an NIH R01 grant mechanism under the health funding activity category, with no cost sharing or matching requirement. The estimated total funding associated with the opportunity is $4,000,000, and the award ceiling is $750,000. The FOA was posted on November 23, 2011, with an original and current closing date of January 23, 2012, and an archive date of February 23, 2012. The listed CFDA number is 93.310 (Trans-NIH Research Support), reflecting the cross-cutting, Common Fund nature of the program.
Eligibility is broad and includes many organization types across academia, government, nonprofit, and industry. Eligible applicants include public and private institutions of higher education, state and local governments (including counties, cities or townships, and special districts), for-profit organizations (including small businesses and other-than-small businesses), federally recognized and other tribal governments and tribal organizations, public housing authorities/Indian housing authorities, independent school districts, and nonprofits both with and without 501(c)(3) status (with the noted exception categories described in the FOA). The eligibility language also explicitly includes a range of special categories such as historically Black colleges and universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and non-U.S. entities (foreign organizations).
For applicants seeking full details, including specific scientific scope, application requirements, review criteria, and any special instructions, the FOA points to the NIH Guide link at http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-11-015.html. The announcement also provides NIH Office of Extramural Research contact support through the OER Webmaster (FBOWebmaster@OD.NIH.GOV) for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The Funding Opportunity Announcement (FOA) is titled "Accelerating the Integration and Translation of Technologies to Characterize Biological Processes at the Single Cell Level (R01)."
What is the funding opportunity number?
The funding opportunity number is RFA-RM-11-015.
What agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant program supported by the NIH Common Fund.
What is the main goal of this FOA?
The central goal is to accelerate promising single-cell analysis technologies past the early prototype stage and into practical, broadly usable tools that other laboratories can adopt.
Is this opportunity focused on inventing new technology from scratch?
No. The FOA emphasizes translation into practice rather than invention for its own sake. It targets the downstream development work that makes a technology reliable and usable in real-world research and clinical environments.
What kinds of activities does the FOA expect applicants to do?
The FOA highlights development steps such as engineering refinement, integrating components into an end-to-end workflow, rigorous performance testing, and validation to ensure the method is robust, well characterized, and ready for broader adoption.
What does "translation into practice" mean in this FOA?
It means taking technologies that already show strong promise and doing the additional development needed to remove barriers to routine use, including improvements in reproducibility, throughput, sensitivity, specificity, and ease of operation.
Why is single-cell analysis a focus of this program?
The FOA stresses that single-cell tools can reveal cell-to-cell heterogeneity, which is important for understanding biological processes where averaging across many cells can hide key subpopulations or transient cellular states.
Does the FOA want tools that are limited to a single sample type?
No. The FOA indicates supported technologies should not be narrowly limited to one highly specific sample type. The program is looking for approaches that can be applied across multiple types of cell populations and provide clear advantages to end users.
In what settings should the resulting technologies be usable?
The FOA frames the goal as developing tools positioned to transform understanding across a wide range of biological contexts, including both research and clinical settings.
What kind of project teams are expected to be competitive?
The announcement places strong emphasis on multidisciplinary, integrative, and quantitative development. Competitive projects are expected to bring together complementary expertise (for example, engineering, quantitative biology, computational analysis, and domain biology or clinical knowledge).
Are measurable milestones required?
Yes. Applicants are expected to define clear goal(s) and include intermediate, measurable milestones that demonstrate stepwise progress toward a validated tool.
How should progress be evaluated under this FOA?
The FOA emphasizes the use of quantitative benchmarks to guide development and to document performance characteristics in a convincing, well-characterized way.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 grant mechanism.
What is the funding activity category?
The funding activity category is Health.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
How much total funding is associated with this opportunity?
The estimated total funding associated with the opportunity is $4,000,000.
What is the award ceiling for individual awards?
The award ceiling is $750,000.
When was the FOA posted?
The FOA was posted on November 23, 2011.
What was the closing date for applications?
The original and current closing date listed is January 23, 2012.
When was the archive date?
The archive date is February 23, 2012.
What is the CFDA number for this program?
The CFDA number is 93.310 (Trans-NIH Research Support).
Who is eligible to apply?
Eligibility is broad and includes many organization types across academia, government, nonprofit, and industry, including public and private institutions of higher education; state and local governments (including counties, cities or townships, and special districts); for-profit organizations (including small businesses and other-than-small businesses); tribal governments and tribal organizations; public housing authorities/Indian housing authorities; independent school districts; and nonprofit organizations with or without 501(c)(3) status (with exception categories noted in the FOA).
Are specific institutional categories explicitly included?
Yes. The eligibility language explicitly includes categories such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and non-U.S. entities (foreign organizations).
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.
Where can applicants find the official FOA details and instructions?
The FOA points to the NIH Guide link for full details, including scientific scope, application requirements, review criteria, and special instructions: http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-11-015.html
Who can be contacted for access or linking issues related to the FOA?
The announcement provides NIH Office of Extramural Research contact support through the OER Webmaster for access or linking issues: FBOWebmaster@OD.NIH.GOV
What is the overarching intent of NIH for funded projects under this FOA?
The stated intent is to fund projects that can credibly deliver a validated single-cell technology that other labs can pick up and use, with well-documented and convincing performance characteristics.
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