Opportunity Information: Apply for PA 16 066

  • The HHS-NIH11 in the education, environment, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Administrative Supplements for Research on Sex/Gender Differences (Admin Supp)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.286, 93.307, 93.313, 93.350, 93.351, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.837, 93.838, 93.839, 93.846, 93.847, 93.853, 93.859, 93.865, 93.866, 93.867,.
  • This funding opportunity was created on Jan 05, 2016 and posted on Jan 05, 2016.
  • Applicants must submit their applications by Mar 04, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $100,000.00 in funding.
  • The number of recipients for this funding is limited to 50 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:

The Administrative Supplements for Research on Sex/Gender Differences (Admin Supp) opportunity (PA-16-066) is a National Institutes of Health (NIH) funding announcement from the U.S. Department of Health and Human Services, specifically through the Office of Research on Women's Health (ORWH). It offers administrative supplement grants to add new, targeted work onto existing NIH-supported projects, with the goal of strengthening research that directly examines how sex and/or gender influences human health and disease. The intent is to ensure that researchers more consistently account for sex as a biological variable and, where relevant, gender-related factors in study design, analysis, and interpretation across the full spectrum of biomedical research.

The focus of the supplements is research that highlights sex/gender differences or similarities, as well as sex and gender factors that shape health outcomes. ORWH signals interest in a wide range of study types, including basic, preclinical, clinical, and behavioral research. Priority areas include work that improves understanding of the significance of biological sex at the cellular level, comparative studies using male and female tissues, and research examining differences across organ systems and physiological systems. The announcement also emphasizes sex-based comparisons in pathophysiology and disease mechanisms, including differences in biomarkers, gene expression patterns, clinical presentation, and approaches to prevention and treatment. In practical terms, this could include supplement activities that add male and female comparisons to an existing model, introduce sex-stratified analyses in an ongoing clinical dataset, or incorporate biomarker or gene expression comparisons that were not in the original scope.

A key requirement is that the proposed supplement work must align with at least one objective from Goals 1 through 3 of the NIH Strategic Plan for Women's Health Research. While the details of those goals are not restated in the summary text provided, the condition matters because it ties each supplement request to NIH's broader strategic priorities for advancing women's health research and improving how sex and gender are integrated into biomedical discovery and translation.

On the administrative side, this is categorized as a discretionary grant funding instrument and spans multiple health-related program areas (listed broadly under education, environment, food and nutrition, health, income security, and social services). The opportunity is associated with a large set of CFDA numbers, reflecting that administrative supplements can attach to many different NIH institutes, centers, and program authorities. The award ceiling is listed at $100,000, and NIH anticipated roughly 50 awards under this notice. The original and current closing date shown is March 4, 2016, with the announcement created and posted on January 5, 2016, indicating this specific posting was time-limited to that application window.

Eligibility is broad and includes many organization types that commonly hold NIH awards. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and certain tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions when specified); for-profit organizations other than small businesses; small businesses; and additional entities as allowed by NIH policy (noted as "others" with clarification in the full text). Because this mechanism is an administrative supplement, it is generally designed for organizations that already have an active NIH grant and want to add a defined set of supplemental aims focused on sex/gender considerations without creating a standalone, independent project.

Overall, the opportunity is meant to accelerate and normalize rigorous sex- and gender-aware science by providing modest, targeted funds to expand existing studies, improve comparative analyses between males and females, and generate clearer evidence on how prevention, diagnosis, and treatment may need to differ by sex and/or gender.

Frequently Asked Questions (FAQs)

What is the Administrative Supplements for Research on Sex/Gender Differences (Admin Supp) opportunity (PA-16-066)?

PA-16-066 is a National Institutes of Health (NIH) funding announcement for administrative supplement grants. These supplements are meant to add new, targeted work to existing NIH-supported projects, specifically to strengthen research that directly examines how sex and/or gender influences human health and disease.

Which agency is sponsoring this opportunity?

This opportunity is offered by the U.S. Department of Health and Human Services through NIH, specifically via the Office of Research on Women's Health (ORWH).

What is the main purpose of these administrative supplements?

The purpose is to accelerate and normalize rigorous sex- and gender-aware science by providing modest, targeted funds that expand existing studies. The supplements aim to ensure researchers more consistently account for sex as a biological variable and, where relevant, gender-related factors in study design, analysis, and interpretation across biomedical research.

Is this a standalone grant or an add-on to an existing project?

It is an administrative supplement, which is designed to add defined supplemental aims to an existing NIH-supported project rather than fund a standalone, independent project.

What kinds of research does the program support?

ORWH indicates interest in a wide range of study types, including basic, preclinical, clinical, behavioral, and other biomedical research, as long as the supplement activities highlight sex/gender differences or similarities and examine sex and gender factors that shape health outcomes.

What research topics are emphasized or prioritized?

Priority areas described include: understanding the significance of biological sex at the cellular level; comparative studies using male and female tissues; examining differences across organ systems and physiological systems; and sex-based comparisons in pathophysiology and disease mechanisms, including differences in biomarkers, gene expression patterns, clinical presentation, and approaches to prevention and treatment.

What are examples of activities that might be supported through a supplement?

Examples described include adding male and female comparisons to an existing model, introducing sex-stratified analyses in an ongoing clinical dataset, or incorporating biomarker or gene expression comparisons that were not included in the original scope of the parent award.

Does the supplement have to connect to any NIH strategic priorities?

Yes. A key requirement is that the proposed supplement work must align with at least one objective from Goals 1 through 3 of the NIH Strategic Plan for Women's Health Research.

What type of funding instrument is this?

It is categorized as a discretionary grant funding instrument.

What is the maximum award amount (award ceiling) mentioned?

The award ceiling listed for this opportunity is $100,000.

About how many awards were anticipated?

NIH anticipated roughly 50 awards under this notice.

When was this specific announcement posted and when did it close?

The announcement was created and posted on January 5, 2016. The original and current closing date shown is March 4, 2016, indicating this posting was time-limited to that application window.

What kinds of organizations are eligible to apply?

Eligibility is broad and includes: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and certain tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions when specified); for-profit organizations other than small businesses; small businesses; and additional entities as allowed by NIH policy (noted as "others" in the full text).

Why are there many different CFDA numbers associated with this opportunity?

The opportunity is associated with a large set of CFDA numbers because administrative supplements can attach to many different NIH institutes, centers, and program authorities across NIH.

Does the opportunity relate only to women's health research?

The opportunity is issued through ORWH and is tied to the NIH Strategic Plan for Women's Health Research, but the supplement focus described is broader: strengthening research that examines how sex and/or gender influences health and disease, including comparisons between males and females and analysis of sex- and gender-related factors across biomedical research.

What kinds of differences or comparisons does the program want researchers to examine?

The program highlights examining sex/gender differences or similarities, including comparisons related to cellular biology, tissues, organ systems, physiological systems, disease mechanisms, biomarkers, gene expression patterns, clinical presentation, and differences in prevention and treatment approaches.

What is the broader impact the program is trying to achieve?

The stated intent is to improve how sex and gender are integrated into biomedical discovery and translation by supporting targeted additions to existing projects, strengthening comparative analyses between males and females, and generating clearer evidence on how prevention, diagnosis, and treatment may need to differ by sex and/or gender.

Are gender-related factors included, or is this only about biological sex?

Both are included in the description. The opportunity emphasizes accounting for sex as a biological variable and, where relevant, incorporating gender-related factors into study design, analysis, and interpretation.

What program areas are these supplements categorized under?

The opportunity is described as spanning multiple health-related program areas, listed broadly under education, environment, food and nutrition, health, income security, and social services.

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Funding Number: PA 16 191
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Funding Number: PA 16 193
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Funding Number: PAR 16 203
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Funding Number: RFA ES 16 003
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Funding Number: RFA ES 16 002
Agency: HHS-NIH11
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Funding Number: RFA LM 16 002
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Funding Number: RFA HG 16 016
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Funding Number: PA 16 285
Agency: HHS-NIH11
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Funding Number: PA 16 286
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Funding Number: PA 16 294
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