Opportunity Information: Apply for PA 13 381
Apply for PA 13 381
- The National Institutes of Health in the education food and nutrition health sector is offering a public funding opportunity titled "Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health 93.393 Cancer Cause and Prevention Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Dec 20, 2013 and posted on Oct 24, 2013.
- Applicants must submit their applications by Oct 31, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts State governments Small businesses City or township governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (PA-13-381) is an NIH administrative supplement opportunity designed to add targeted funds onto existing, active research grants supported by the National Cancer Institute (NCI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The central purpose is to help current awardees perform validation studies for analytical chemistry methods that they have already developed, or are actively developing, under their parent grant. In practical terms, this program is not for launching a brand-new standalone project; it is meant to strengthen the rigor and usability of methods work that is already underway within an ongoing NIH-funded study.
The methods supported under this supplement are specifically analytical approaches used to identify and quantify chemical constituents relevant to orally administered natural products. That includes measuring bioactive constituents and other marker compounds, as well as tracking metabolites, detecting adulterants, and identifying contaminants. The methods can be applied either directly to products intended for human oral use (for example, finished dietary supplement products, foods, or other oral natural product preparations) or to biological specimens where those constituents or metabolites might be measured, such as urine, plasma, or animal tissues. The FOA also makes room for studies in both in vitro and in vivo settings, meaning the test agents can be evaluated in laboratory systems or in living organisms, as appropriate to the parent award.
In terms of the products that can serve as test agents, the scope is broad within the natural products and orally administered space. It explicitly includes dietary supplements, which may involve vitamins or other bioactive compounds, and extends to foods and other natural products taken by mouth, as well as the raw source materials used to produce them. The emphasis is on analytical credibility and comparability: validated methods are critical for confidently determining what is actually in a product, what reaches the body, what metabolites appear, and whether unwanted or undisclosed substances are present.
This is a discretionary grant opportunity using the administrative supplement mechanism, meaning applicants must already hold an eligible NIH parent award (supported by NCI or NIDDK) and seek additional funds to conduct the validation work. The total estimated funding listed for the program is $800,000, with an award ceiling of $100,000 per supplement. The announcement indicates there is no cost sharing or matching requirement.
Eligibility is described broadly across many organization types, including for-profit entities (other than small businesses), small businesses, a wide range of nonprofit organizations (including 501(c)(3) and non-501(c)(3) nonprofits), public and private institutions of higher education, and various government entities (state, county, city/township, special district), as well as tribal governments and tribal organizations. The eligibility details also explicitly reference categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions, reinforcing that many institutional types could participate as long as they meet the key requirement of having an active, relevant parent award.
Key administrative details include the posting date of October 24, 2013, and a closing date of October 31, 2015 (with an archive date of December 1, 2015). The opportunity is associated with multiple CFDA program areas, reflecting its cross-cutting relevance to complementary and integrative health, cancer prevention research, diabetes/digestive/kidney extramural research, and aging research (CFDA numbers 93.213, 93.393, 93.847, and 93.866). The sponsoring agency is the National Institutes of Health, and the full FOA was available through the NIH grants guide at the link provided in the announcement. For access or linking issues, the listed contact is the NIH Office of Extramural Research (OER) webmaster.
FAQs: Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (PA-13-381)
What is PA-13-381?
PA-13-381 is an NIH administrative supplement opportunity that provides additional (supplemental) funds to certain existing NIH awards so current grantees can conduct validation studies of analytical chemistry methods for orally administered natural products.
Is this a standalone grant for a brand-new project?
No. This is an administrative supplement, which is designed to add targeted funds to an existing, active parent award. The intent is to strengthen and validate methods work that is already developed or actively developing under the current NIH-funded project, rather than launch a new independent project.
Which NIH Institutes are involved?
The supplement is tied to active research grants supported by the National Cancer Institute (NCI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the broader umbrella of the National Institutes of Health (NIH).
What is the primary purpose of this supplement?
The central purpose is to help eligible awardees perform validation studies for analytical methods relevant to orally administered natural products, improving rigor, credibility, and usability of measurements used in the parent award.
What types of methods does the supplement support?
The supplement supports analytical approaches used to identify and quantify chemical constituents relevant to orally administered natural products. This includes methods for measuring bioactive constituents and marker compounds, tracking metabolites, detecting adulterants, and identifying contaminants.
What does "validation studies" mean in the context of this opportunity?
Based on the announcement, validation studies are efforts to demonstrate that an analytical method can reliably identify and quantify relevant constituents (and related signals such as metabolites, adulterants, or contaminants) in the intended sample types and use cases associated with the parent award.
What kinds of natural products are in scope as test agents?
The scope is broad for orally administered natural products. It explicitly includes dietary supplements (including vitamins or other bioactive compounds), foods, other natural products taken by mouth, and the raw source materials used to produce them.
Are dietary supplements specifically included?
Yes. Dietary supplements are explicitly included, and the supplement may support analytical methods that assess the composition and integrity of finished products and/or their source materials.
Can the analytical methods be applied to finished products as sold to consumers?
Yes. The announcement includes products intended for human oral use, such as finished dietary supplement products, foods, or other oral natural product preparations.
Can the methods be used on biological specimens (not just on the product itself)?
Yes. The supported methods can be applied to biological specimens where constituents or metabolites might be measured, including urine, plasma, or animal tissues.
Does the opportunity allow both in vitro and in vivo studies?
Yes. The announcement allows studies in both in vitro and in vivo settings, as appropriate to the scope and needs of the parent award.
What kinds of analytes or issues can the methods target?
The opportunity highlights measuring bioactive constituents and other marker compounds, tracking metabolites, detecting adulterants, and identifying contaminants in relevant products or biological samples.
Why is this supplement focused on analytical method credibility and comparability?
The announcement emphasizes that validated methods are critical for confidently determining what is in a product, what reaches the body, what metabolites appear, and whether unwanted or undisclosed substances are present.
Who can apply for this administrative supplement?
Applicants must already hold an eligible, active NIH parent award supported by NCI or NIDDK and request supplemental funds to conduct the validation work described in the opportunity.
Are many organization types eligible, or is it limited to universities?
Eligibility is broad across many organization types (subject to the key requirement of holding an eligible active parent award), including public and private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3)), for-profit entities (other than small businesses), small businesses, and a wide range of government and tribal entities.
Are small businesses eligible?
Yes. Small businesses are listed among eligible organization types, as long as the organization also meets the core requirement of having an eligible, active parent NIH award supported by NCI or NIDDK.
Are for-profit organizations eligible?
Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed separately as eligible categories, contingent on having an eligible active parent award.
Are nonprofits eligible?
Yes. The eligibility list includes a wide range of nonprofit organizations, including 501(c)(3) and non-501(c)(3) nonprofits.
Are government entities eligible?
Yes. The eligibility list includes state, county, city/township, and special district governments, as well as tribal governments and tribal organizations.
Are institutions serving specific communities explicitly included?
Yes. The eligibility details explicitly reference categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, AANAPISIs, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Is cost sharing or matching required?
No. The announcement indicates there is no cost sharing or matching requirement.
How much funding is available through this opportunity?
The total estimated funding for the program is listed as $800,000.
What is the maximum amount per supplement award?
The award ceiling is $100,000 per supplement.
Is this opportunity discretionary?
Yes. The announcement describes it as a discretionary grant opportunity using the administrative supplement mechanism.
What are the key dates for this FOA?
The posting date is October 24, 2013. The closing date is October 31, 2015. The archive date is December 1, 2015.
Which CFDA program areas are associated with this opportunity?
The opportunity is associated with CFDA numbers 93.213, 93.393, 93.847, and 93.866, reflecting relevance to complementary and integrative health, cancer prevention research, diabetes/digestive/kidney extramural research, and aging research.
Where was the full FOA originally posted?
The full FOA was available through the NIH grants guide at the link provided in the announcement.
Who should be contacted for access or linking issues with the FOA?
For access or linking issues, the listed contact is the NIH Office of Extramural Research (OER) webmaster.
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