Opportunity Information: Apply for PA 16 048
Apply for PA 16 048
- The HHS-NIH11 in the education, food and nutrition, health sector is offering a public funding opportunity titled "Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.321, 93.393, 93.394, 93.395, 93.847, 93.859,.
- This funding opportunity was created on Dec 04, 2015 and posted on Dec 04, 2015.
- Applicants must submit their applications by Apr 15, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $100,000.00 in funding.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp)" (Funding Opportunity Number PA-16-048) is an NIH administrative supplement program designed to strengthen the rigor, reproducibility, and transparency of research involving natural products and dietary supplements. Its core purpose is to fund formal validation work for quantitative analytical methods, and to support the publication of those validated methods so other researchers can measure the same chemical constituents reliably across laboratories, studies, and product sources. In practical terms, the program targets a common problem in natural products research: variability and uncertainty in what is actually present in an herb, extract, supplement, or biological sample, which can undermine both mechanistic research and clinical studies.
This opportunity is specifically meant as an administrative supplement to certain active NIH awards administered by participating NIH Institutes and Centers (ICs). That means it is not a standalone grant for launching a brand-new, unrelated project. Instead, the proposed validation studies must directly relate to the scientific goals of an existing parent award, and the analytical method being validated must have been developed or already used as part of achieving that parent grant's specific aims. The intent is to take methods that were already integral to the ongoing research and bring them up to a higher standard through structured validation, then disseminate them in a way that supports broader adoption.
The analytical methods eligible for support must be quantitative and focused on identifying and measuring chemical constituents relevant to natural products and dietary supplements. The constituents can include active compounds or marker compounds used to characterize a botanical or supplement, as well as adulterants, contaminants, or metabolites of those substances. The program makes clear that methods can be applied not only to experimental reagents and raw materials (such as plant material, extracts, or finished supplement products) but also to clinical specimens, including matrices like urine or plasma. This emphasis reflects the reality that strong natural products research often spans from characterizing materials used in experiments to confirming exposure, metabolism, and pharmacokinetics in animals or humans.
A notable feature of the program is the breadth of chemical targets considered relevant. Candidate constituents for validation studies may include phytochemicals and nutrients, as well as potentially harmful substances that can appear in natural products supply chains, such as pesticides and mycotoxins. By supporting validated methods for both beneficial constituents and potentially deleterious contaminants, the supplement mechanism aligns with both scientific quality and public health concerns, including the need to detect adulteration and contamination that could confound research outcomes or pose safety risks.
From an administrative and funding standpoint, this is a discretionary grant mechanism under HHS-NIH. The listed award ceiling is $100,000, and the program anticipated making around 8 awards. The opportunity was posted on December 4, 2015, created the same day, and had a closing date of April 15, 2017 (with the original and current closing dates matching in the source information). The CFDA program numbers associated with this opportunity include 93.213, 93.321, 93.393, 93.394, 93.395, 93.847, and 93.859, reflecting that multiple NIH components and related program areas can be involved.
Eligibility is broad and includes many common U.S. research and public-sector entities, such as state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (with distinctions noted for those outside higher education); for-profit organizations other than small businesses; and small businesses. The listing also includes an "Others" category with direction to consult additional eligibility text, which is typical for NIH announcements where specific conditions can depend on the parent award and the participating IC policies.
Overall, the opportunity is best understood as targeted NIH support to turn useful, study-specific analytical approaches into well-validated, publishable quantitative methods for natural products research. By funding validation tied to active NIH projects, NIH aims to reduce ambiguity in what researchers are testing or measuring, improve comparability across studies, and ultimately make findings involving botanicals and dietary supplements more dependable for biomedical science.
FAQs: Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp) (PA-16-048)
What is this funding opportunity?
This opportunity, titled "Administrative Supplements to NIH Awards for Validation Studies of Analytical Methods for Natural Products (Admin Supp)" (Funding Opportunity Number PA-16-048), is an NIH administrative supplement program. It is intended to strengthen rigor, reproducibility, and transparency in research involving natural products and dietary supplements by supporting formal validation of quantitative analytical methods and encouraging publication of those validated methods.
What problem is NIH trying to solve with this supplement?
The program targets a common challenge in natural products and dietary supplement research: variability and uncertainty in what is actually present in an herb, extract, supplement, or biological sample. That uncertainty can weaken mechanistic studies and clinical research. By supporting validation and publication of quantitative methods, NIH aims to help researchers measure the same constituents reliably across laboratories, studies, and product sources.
Is this a standalone grant or an add-on to an existing NIH award?
This is an administrative supplement to certain active NIH awards administered by participating NIH Institutes and Centers (ICs). It is not described as a standalone grant for starting a new, unrelated project.
How must the proposed work relate to the parent (existing) award?
The proposed validation studies must directly relate to the scientific goals of the existing parent award. In addition, the analytical method being validated must have been developed or already used as part of achieving the parent grant's specific aims.
What types of methods are eligible for support?
Eligible methods must be quantitative analytical methods focused on identifying and measuring chemical constituents relevant to natural products and dietary supplements.
What kinds of chemical constituents can the validated method measure?
The opportunity includes a broad set of possible targets, including:
- Active compounds
- Marker compounds used to characterize a botanical or supplement
- Adulterants
- Contaminants
- Metabolites of natural products or dietary supplement substances
- Phytochemicals and nutrients
- Potentially harmful substances that may appear in supply chains, such as pesticides and mycotoxins
Can the method be validated for use on finished supplements and raw materials?
Yes. The program notes that validated methods can apply to experimental reagents and raw materials such as plant material, extracts, or finished supplement products.
Can the method be validated for use on clinical or biological samples?
Yes. The opportunity explicitly includes application to clinical specimens and matrices such as urine or plasma. This reflects the need to connect material characterization with exposure, metabolism, and pharmacokinetics in animals or humans.
What is the main purpose of funding validation studies under this supplement?
The central goal is to support structured, formal validation work for quantitative analytical methods so that other researchers can measure the same chemical constituents reliably across laboratories, studies, and product sources. The opportunity also emphasizes support for publication of those validated methods to enable broader adoption.
Does the opportunity emphasize publishing validated methods?
Yes. A key element described is supporting the publication of validated methods so other researchers can use them and generate comparable measurements.
Why does the opportunity include contaminants and adulterants as targets?
By supporting validated methods for both beneficial constituents and potentially deleterious contaminants, the supplement aligns with scientific quality and public health concerns. Detecting adulteration or contamination can prevent confounding research outcomes and address safety risks.
What is the maximum funding amount mentioned?
The listed award ceiling is $100,000.
How many awards were anticipated?
The opportunity anticipated making around 8 awards.
Which federal agency and program mechanism is this?
This is a discretionary grant mechanism under HHS-NIH (the U.S. Department of Health and Human Services, National Institutes of Health) and is offered as an administrative supplement to certain active NIH awards.
When was this opportunity posted and when did it close?
The opportunity was posted on December 4, 2015 (created the same day) and had a closing date of April 15, 2017. The source information indicates the original and current closing dates match.
What are the CFDA program numbers associated with this opportunity?
The CFDA program numbers listed for this opportunity are: 93.213, 93.321, 93.393, 93.394, 93.395, 93.847, and 93.859.
Who is eligible to apply based on the listing?
Eligibility is described as broad and includes the following entity types:
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities / Indian housing authorities
- Nonprofit organizations with 501(c)(3) status (other than institutions of higher education)
- Nonprofit organizations without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations other than small businesses
- Small businesses
- Others (with direction to consult additional eligibility text)
Does broad eligibility mean any organization can apply regardless of NIH funding status?
The opportunity is described as an administrative supplement to certain active NIH awards administered by participating NIH ICs. That structure implies the supplement is tied to an existing parent award, and the proposed validation work must relate to that parent award's goals and methods already used or developed under it.
What makes this supplement different from simply improving a lab method internally?
The emphasis is on formal validation and dissemination: structured validation work that strengthens rigor and reproducibility, plus publication of the validated method so it can be used reliably across different labs, studies, and product sources.
What is the big-picture outcome NIH is aiming for?
NIH aims to reduce ambiguity in what researchers are testing or measuring in natural products and dietary supplement research, improve comparability across studies, and make resulting findings more dependable for biomedical science.
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| Health Promotion Among Racial and Ethnic Minority Males (R01 Clinical Trial Optional) Apply for PA 18 144 Funding Number: PA 18 144 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health Funding Amount: Case Dependent |
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| Diet and Physical Activity Assessment Methodology (R01 Clinical Trial Not Allowed) Apply for PA 18 856 Funding Number: PA 18 856 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health Funding Amount: Case Dependent |
| Diet and Physical Activity Assessment Methodology (R21 Clinical Trial Not Allowed) Apply for PAR 18 857 Funding Number: PAR 18 857 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health Funding Amount: $200,000 |
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