Opportunity Information: Apply for RFA MH 17 405
Apply for RFA MH 17 405
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Adult Maturational Changes and Dysfunctions in Emotion Regulation (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.866.
- This funding opportunity was created on Mar 29, 2016 and posted on Mar 29, 2016.
- Applicants must submit their applications by Jul 22, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Adult Maturational Changes and Dysfunctions in Emotion Regulation (R01) funding opportunity (RFA-MH-17-405) was a discretionary NIH grant solicitation under HHS (listed as HHS-NIH11) seeking mechanistic research that explains how emotion processing and emotion regulation change across adulthood, and how those age- and sex-related changes connect to affective dysregulation seen in adult mental disorders and in Alzheimers disease. The core scientific premise is that, for many people, emotion regulation tends to improve with age under normative conditions, and the FOA encourages applicants to treat that well-documented pattern as an important reference point. Projects were expected to either leverage the existing evidence base on normative emotional aging or to strengthen and expand it, then use that foundation to better interpret when, how, and why emotion regulation goes off track in clinical or neurodegenerative contexts.
A central goal of the announcement was to map trajectories of change in emotion processing over the adult life course, with specific attention to how these trajectories differ by sex and how they unfold in people experiencing mood and anxiety disorders as they age. This includes characterizing links between emotion-related behavioral changes and underlying neurobiological and neurobehavioral factors, such as brain circuitry supporting affect regulation, cognitive control processes that shape emotional responses, and other integrative brain-behavior mechanisms. In practical terms, the FOA was pushing the field beyond simple descriptions of age differences toward explanations of mechanisms: which systems change with age, how those changes alter emotional responses and regulation strategies, and how those mechanisms differ in typical aging versus psychopathology or Alzheimers-related processes.
Equally emphasized was the need to explain why individuals vary so widely in emotional aging. The FOA highlights normative maturational shifts in emotion regulation as an important phenomenon in its own right, and it invites research on the factors that drive these shifts and the sources of individual differences. That can include identifying contributors that promote resilience and improved regulation with age, as well as factors that blunt, delay, or reverse normative improvements. The announcement also points to the importance of determining how the presence or absence of normative maturational shifts relates to the irregularities in neural-behavioral regulation systems commonly observed in adult mood and anxiety disorders and in Alzheimers disease, essentially asking whether atypical emotional aging profiles can help explain vulnerability, symptom course, or transitions in functioning later in life.
A key translational motivation behind the FOA was intervention relevance. By clarifying mechanisms and developmental timing, NIH signaled interest in studies that could reveal new prevention or treatment targets or refine how existing interventions are deployed. The idea is that if researchers can pinpoint which emotion regulation components normally strengthen at certain adult stages, and which components fail to mature or become disrupted in particular disorders or in Alzheimers disease, then interventions can be more precisely matched to the mechanism and the life stage. This could mean identifying leverage points for normalizing dysregulated affect, improving emotional resilience, or informing when certain therapeutic strategies might be most effective across adulthood and into older age.
Administratively, this opportunity used the NIH R01 research project grant mechanism in the health funding activity category and was associated with CFDA numbers 93.242 and 93.866. Eligibility was broad and included multiple levels of government (state, county, city/township, special districts), public and private institutions of higher education, independent school districts, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories), for-profit organizations other than small businesses, and small businesses, with a note that additional eligibility clarification could apply per the full announcement text. The FOA was posted March 29, 2016, created the same day, and had an original and current closing date of July 22, 2016. The publicly listed fields for award ceiling and expected number of awards were not specified in the provided data, indicating that applicants would have needed to consult the full FOA for any budgetary or award volume guidance not captured in the summary record.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled Adult Maturational Changes and Dysfunctions in Emotion Regulation (R01) with the funding opportunity number RFA-MH-17-405.
Which agency offered this grant opportunity?
It was a discretionary National Institutes of Health (NIH) solicitation under the U.S. Department of Health and Human Services (HHS), listed as HHS-NIH11.
What type of grant mechanism was used?
This opportunity used the NIH R01 research project grant mechanism.
What research area did the FOA focus on?
The FOA sought mechanistic research explaining how emotion processing and emotion regulation change across adulthood, and how age- and sex-related changes relate to affective dysregulation in adult mental disorders and in Alzheimers disease.
What was the core scientific premise behind the announcement?
A central premise was that under normative conditions, emotion regulation tends to improve with age for many people. The FOA encouraged applicants to treat this well-documented normative pattern as an important reference point for interpreting dysfunction in clinical or neurodegenerative contexts.
What did NIH mean by a focus on "mechanisms" rather than descriptions?
The FOA pushed the field beyond simply describing age differences. It emphasized identifying which systems change with age, how those changes alter emotional responses and regulation strategies, and how mechanisms differ across typical aging versus mood/anxiety disorders or Alzheimers-related processes.
What kinds of trajectories was the FOA interested in mapping?
A central goal was to map trajectories of change in emotion processing over the adult life course, including attention to how trajectories differ by sex and how they unfold in people with mood and anxiety disorders as they age.
What domains or systems were highlighted as relevant to emotion regulation mechanisms?
The FOA highlighted links between emotion-related behavioral change and underlying neurobiological and neurobehavioral factors, including brain circuitry supporting affect regulation, cognitive control processes shaping emotional responses, and other integrative brain-behavior mechanisms.
How did the FOA treat normative emotional aging evidence?
Projects were expected to either leverage the existing evidence base on normative emotional aging or strengthen and expand it, and then use that foundation to better interpret when, how, and why emotion regulation goes off track in disorders or in Alzheimers disease.
Did the FOA emphasize individual differences in emotional aging?
Yes. It emphasized explaining why people vary widely in emotional aging, including identifying factors that promote resilience and improved regulation with age, as well as factors that blunt, delay, or reverse normative improvements.
How did the FOA connect normative shifts to mood and anxiety disorders?
It pointed to determining how the presence or absence of normative maturational shifts relates to irregularities in neural-behavioral regulation systems commonly seen in adult mood and anxiety disorders, including whether atypical emotional aging profiles help explain vulnerability, symptom course, or later-life transitions in functioning.
How did the FOA connect emotion regulation research to Alzheimers disease?
It aimed to link age-related changes in emotion regulation to affective dysregulation in Alzheimers disease, including understanding how mechanisms differ in typical aging versus Alzheimers-related processes.
Was the opportunity intended to inform interventions?
Yes. A translational motivation was to clarify mechanisms and developmental timing in ways that could reveal new prevention or treatment targets or refine how existing interventions are deployed by better matching intervention strategies to mechanism and life stage.
What is the health funding activity category mentioned?
The announcement is described as being in the health funding activity category.
Which CFDA numbers were associated with this FOA?
The opportunity was associated with CFDA numbers 93.242 and 93.866.
Who was eligible to apply?
Eligibility was broad and included:
- State governments
- County governments
- City or township governments
- Special district governments
- Public and private institutions of higher education
- Independent school districts
- Federally recognized tribal governments and other tribal organizations
- Public housing authorities / Indian housing authorities
- Nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories)
- For-profit organizations other than small businesses
- Small businesses
Was there any note about additional eligibility requirements?
Yes. The summary indicates that additional eligibility clarification could apply depending on the full announcement text.
When was the FOA posted and created?
The FOA was posted on March 29, 2016 and created the same day.
What was the closing date for applications?
The original and current closing date listed was July 22, 2016.
Were the award ceiling and expected number of awards provided in the summary?
No. The publicly listed fields for the award ceiling and expected number of awards were not specified in the provided summary data, implying that applicants would have needed to consult the full FOA for budget or award volume details not captured in the record.
Does the summary specify exact budget limits or how many awards would be made?
No. Those fields were not specified in the provided data, so any specific budget caps or expected award counts would not be available from the summary alone.
What populations or life stages were emphasized?
The FOA emphasized changes across adulthood and into older age, with attention to how emotion processing and regulation evolve across the adult life course.
What role did sex differences play in the FOA?
Sex was explicitly highlighted. The FOA called for attention to how trajectories of emotion processing and regulation differ by sex and how those differences relate to typical aging and to dysfunction in disorders or Alzheimers disease.
What did the FOA suggest researchers do with the normative reference pattern?
It suggested using the normative pattern (emotion regulation often improving with age) as a baseline for understanding when, how, and why regulation becomes dysregulated in clinical or neurodegenerative settings.
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