Opportunity Information: Apply for RFA MH 17 400
Apply for RFA MH 17 400
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Adult Maturational Changes and Dysfunctions in Emotion Regulation (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.866,.
- This funding opportunity was created on Mar 30, 2016 and posted on Mar 30, 2016.
- Applicants must submit their applications by Jul 22, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
Adult Maturational Changes and Dysfunctions in Emotion Regulation (R21) is a National Institutes of Health funding opportunity (HHS-NIH) that supports early-stage, exploratory research aimed at unpacking how emotion regulation changes across adulthood and what happens when those changes go off track. The focus is explicitly mechanistic, meaning the program is looking for studies that do more than describe patterns in mood or behavior. Proposed projects should probe the underlying neural, biological, and behavior-linked processes that shape how adults perceive, process, and regulate emotions over time, and how these processes differ by age and sex.
A central idea behind the announcement is that emotion regulation often improves with age in the general population, and that this established "normative" trend can be used as a powerful comparison point. Applicants are encouraged to leverage what is already known about these typical maturational shifts while also extending the evidence base, for example by identifying when and why emotion regulation improves, what components of emotional processing are changing, and which neurobiological or neurobehavioral systems are involved. In addition to mapping typical aging-related trajectories, the FOA places strong emphasis on individual differences: why some people show greater gains in emotional resilience across adulthood while others do not, and which factors (biological, psychological, social, or experiential) explain that variability.
At the same time, the opportunity is geared toward understanding affective dysregulation in conditions where emotion regulation is disrupted, especially adult mood and anxiety disorders and Alzheimers disease. One key aim is to clarify how trajectories of emotional processing and related neurobiological or neurobehavioral markers unfold in aging adults who experience depression, anxiety, or related disorders. Another equally important aim is to determine how typical maturational changes in emotion regulation, or the absence of those changes, may relate to the irregular neural-behavioral integration that characterizes these disorders and Alzheimers disease. In practice, this means the program is interested in work that can connect age-related change to disease-related mechanisms, rather than treating aging and psychopathology as separate topics.
Because this is an R21 mechanism, it is positioned as exploratory and developmental. The expectation is that applicants may propose innovative, higher-risk studies that generate preliminary evidence, test novel mechanistic hypotheses, or establish proof-of-concept for new models, measures, or analytic approaches. The announcement anticipates that findings from these projects could reveal new intervention targets or inform prevention strategies. It also suggests a practical payoff: understanding which existing interventions might work best at different stages of adulthood, either to normalize emotion dysregulation in clinical populations or to strengthen resilience and emotional well-being across the adult life course.
From an administrative standpoint, the opportunity is classified as a discretionary NIH grant in the health funding category, with CFDA numbers 93.242 and 93.866. Eligible applicants are broad and include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and various governmental entities including state, county, city/township, special districts, and tribal governments and organizations, as well as public housing authorities and other eligible entities as specified in NIH guidance. The award ceiling listed is $200,000, and the funding opportunity number is RFA MH 17 400. The original and current closing date shown is July 22, 2016, and the posting and creation date is March 30, 2016.
Frequently Asked Questions (FAQs)
What is the "Adult Maturational Changes and Dysfunctions in Emotion Regulation (R21)" opportunity?
This is a National Institutes of Health (NIH) funding opportunity that supports early-stage, exploratory research focused on how emotion regulation changes across adulthood and what happens when those changes become disrupted.
Which agency sponsors this funding opportunity?
The sponsor is the National Institutes of Health (HHS-NIH).
What is the funding opportunity number (FOA number)?
The funding opportunity number provided is RFA MH 17 400.
What grant mechanism does this program use?
This opportunity uses the NIH R21 mechanism, which is designed for exploratory and developmental research.
What does it mean that the FOA is "mechanistic"?
It means the program is looking for studies that go beyond describing emotions, mood, or behavior patterns. Proposed projects should probe underlying neural, biological, and behavior-linked processes that shape how adults perceive, process, and regulate emotions over time.
What is the main scientific focus of the FOA?
The FOA focuses on adult maturational changes in emotion regulation, including typical (normative) improvements across adulthood, and on dysfunctions in emotion regulation when those age-related changes go off track.
Is the FOA focused only on typical aging?
No. The FOA supports both research on typical aging-related trajectories in emotion regulation and research on affective dysregulation in conditions where emotion regulation is disrupted.
How does the FOA treat "normative" emotion regulation trends across adulthood?
A central idea is that emotion regulation often improves with age in the general population, and this normative trend can serve as a powerful comparison point. Applicants are encouraged to leverage what is already known about these typical shifts while extending the evidence base.
What kinds of questions about typical emotion regulation changes does the FOA encourage?
The FOA highlights questions such as when and why emotion regulation improves, what components of emotional processing change with age, and which neurobiological or neurobehavioral systems are involved.
Does the FOA emphasize individual differences in emotion regulation outcomes?
Yes. It places strong emphasis on why some individuals show greater gains in emotional resilience across adulthood while others do not, and which biological, psychological, social, or experiential factors explain that variability.
Are age and sex differences relevant to proposed projects?
Yes. The FOA specifically notes interest in how underlying processes differ by age and sex.
Which conditions are specifically highlighted for emotion regulation dysfunction research?
The FOA specifically highlights adult mood and anxiety disorders and Alzheimers disease as areas where emotion regulation is disrupted.
What kinds of studies are encouraged in relation to depression and anxiety in aging adults?
The FOA is interested in clarifying how trajectories of emotional processing and related neurobiological or neurobehavioral markers unfold in aging adults who experience depression, anxiety, or related disorders.
How does the FOA connect aging research with psychopathology and Alzheimers disease?
It encourages work that connects age-related change to disease-related mechanisms, rather than treating aging and psychopathology as separate topics. This includes examining how typical maturational changes (or the absence of those changes) relate to irregular neural-behavioral integration in these disorders and Alzheimers disease.
What does the FOA mean by "irregular neural-behavioral integration"?
Based on the description provided, it refers to atypical relationships between neural processes and behavioral outcomes that characterize certain disorders (including mood/anxiety disorders) and Alzheimers disease, in the context of emotion regulation and aging.
What type of projects are a good fit for an R21 under this FOA?
The FOA positions the R21 as exploratory and developmental, anticipating innovative and potentially higher-risk studies that generate preliminary evidence, test novel mechanistic hypotheses, or establish proof-of-concept for new models, measures, or analytic approaches.
Are descriptive studies about mood or behavior likely to be competitive under this FOA?
The FOA states the focus is explicitly mechanistic and seeks studies that do more than describe patterns in mood or behavior, suggesting projects should be designed to test or reveal underlying processes and mechanisms.
What outcomes or impacts does the FOA anticipate from funded projects?
The FOA anticipates that findings could reveal new intervention targets or inform prevention strategies, and may help determine which existing interventions might work best at different stages of adulthood to normalize dysregulation or strengthen resilience and emotional well-being.
Does the FOA allow projects that develop new tools or methods?
Yes. The description explicitly mentions proof-of-concept for new models, measures, or analytic approaches as within the scope of an R21 under this FOA.
What is the award ceiling listed for this opportunity?
The award ceiling listed is $200,000.
How is this opportunity classified administratively?
It is classified as a discretionary NIH grant in the health funding category.
What CFDA numbers are associated with this funding opportunity?
The CFDA numbers listed are 93.242 and 93.866.
Who is eligible to apply?
Eligible applicants are broad and include public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); for-profit organizations (other than small businesses); small businesses; and governmental entities including state, county, city/township, special districts, and tribal governments and organizations. Public housing authorities and other eligible entities as specified in NIH guidance are also included.
Are small businesses eligible?
Yes, small businesses are included among eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, with the note that eligibility includes for-profit organizations other than small businesses (and small businesses are also listed separately as eligible).
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and organizations are explicitly included among eligible applicants.
Are public housing authorities eligible to apply?
Yes. Public housing authorities are listed among eligible entities.
What are the important dates for this opportunity?
The posting and creation date is March 30, 2016. The original and current closing date shown is July 22, 2016.
Is the closing date the same as the original closing date?
Yes. The information provided states that the original and current closing date shown is July 22, 2016.
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