Opportunity Information: Apply for RFA DA 15 005
Apply for RFA DA 15 005
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Feb 5, 2014 and posted on Feb 4, 2014.
- Applicants must submit their applications by Jul 31, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Small businesses Private institutions of higher education Public and State controlled institutions of higher education State governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Native American tribal governments (Federally recognized) Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity titled "Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01)" (Funding Opportunity Number RFA-DA-15-005) was a discretionary grant program designed to support highly innovative, investigator-driven research at the R01 level that sits squarely at the intersection of HIV/AIDS and substance use. The core intent was to push the field toward new ideas that could open up entirely new directions in HIV research and, in particular, produce practical advances in HIV prevention and treatment for people who use drugs. A central expectation was that applicants would clearly and explicitly describe the substance use nexus, meaning the application needed to do more than mention drug use as background or context; the proposed aims had to meaningfully engage with how substance use influences HIV risk, transmission, disease course, care engagement, treatment outcomes, or related prevention and intervention strategies.
This FOA was positioned as a complement to the NIH Avant-Garde Award for HIV/AIDS research. In contrast to the Avant-Garde mechanism, which emphasizes high-risk, high-reward concepts and does not require a detailed research plan, this R01 FOA expected a traditional, rigorous R01-style application package. That included a detailed research strategy and preliminary data, signaling that while innovation was strongly emphasized, the project still needed to be well-justified, feasible, and grounded in evidence that the approach could work. In practical terms, the FOA was looking for proposals that were bold and creative but also methodologically sound and ready to be executed as a full research project rather than a purely speculative concept.
The opportunity was intentionally broad in scientific scope. It was not limited to one discipline, one methodological approach, or one segment of the HIV/substance use continuum. Both individual investigators and collaborative research teams were encouraged to apply, which left room for projects ranging from basic and translational science to clinical, behavioral, implementation, and population-level research, as long as the innovation and the HIV-plus-substance-use linkage were clear and central. The activity category was listed under Education and Health, with the CFDA number 93.279 (Drug Abuse and Addiction Research Programs), reflecting the strong alignment with research priorities in drug abuse and addiction and their implications for HIV outcomes.
From an administrative standpoint, the program used the standard NIH grant funding instrument (Grant) under the R01 mechanism and did not require cost sharing or matching funds. The estimated total funding available for the FOA was $2,000,000. The opportunity was posted on February 4, 2014, created February 5, 2014, and had an original and current closing date of July 31, 2014, with an archive date of August 31, 2014. The sponsoring agency was NIH, and the full announcement was available via the NIH Grants Guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-15-005.html.
Eligibility was expansive and included a wide range of domestic and international applicants. Eligible organizations included nonprofits (with and without 501(c)(3) status), public and private institutions of higher education, small businesses, for-profit organizations (other than small businesses), and multiple levels of government entities (city/township, county, state, special district governments), as well as public housing authorities/Indian housing authorities. The FOA also explicitly included historically underserved and mission-specific institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations, tribal organizations, and U.S. territories or possessions. Importantly, non-U.S. entities and foreign institutions were eligible, non-U.S. components of U.S. organizations could apply, and foreign components (as defined by NIH policy) were allowed, which broadened the program’s potential impact by enabling global or cross-national work where relevant to HIV and substance use.
For applicants who encountered technical issues accessing the announcement or linking to it, the listed point of contact was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV). Overall, the FOA can be understood as a targeted push to generate exceptional, forward-looking R01 projects that move beyond incremental advances and instead create new scientific or practical pathways to reduce HIV burden among people affected by substance use.
Frequently Asked Questions (FAQs)
What is the title and number of this NIH funding opportunity?
The funding opportunity is titled "Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01)" and the Funding Opportunity Number is RFA-DA-15-005.
What type of grant mechanism does this opportunity use?
This opportunity uses the standard NIH grant funding instrument under the R01 mechanism.
What is the main purpose of this FOA?
The FOA was designed to support highly innovative, investigator-driven R01 research that sits at the intersection of HIV/AIDS and substance use, with the aim of opening new directions in HIV research and generating practical advances in HIV prevention and treatment for people who use drugs.
How central does substance use need to be in the proposed research?
Substance use is expected to be a central and explicit part of the application. The FOA emphasized that applicants needed to clearly describe the substance use nexus, meaning the project aims should meaningfully engage with how substance use influences HIV risk, transmission, disease course, care engagement, treatment outcomes, or related prevention and intervention strategies (not just mention drug use as background).
Is this opportunity focused on high-risk concepts without a detailed plan, like some other NIH awards?
No. This FOA was positioned as a complement to the NIH Avant-Garde Award for HIV/AIDS research. Unlike the Avant-Garde mechanism (which does not require a detailed research plan), this R01 FOA expected a traditional, rigorous R01-style application package.
Does the application require a detailed research strategy and preliminary data?
Yes. The FOA expected a traditional R01-style application with a detailed research strategy and preliminary data, signaling that projects should be innovative but also feasible, well-justified, and grounded in evidence.
What kinds of research approaches were considered responsive?
The FOA was intentionally broad and not limited to one discipline or method. It encouraged proposals ranging from basic and translational science to clinical, behavioral, implementation, and population-level research, as long as the innovation and the HIV-plus-substance-use linkage were clear and central.
Who was encouraged to apply: single investigators or teams?
Both individual investigators and collaborative research teams were encouraged to apply.
Which agency sponsored this opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
What is the CFDA number associated with this program?
The CFDA number listed for this FOA is 93.279 (Drug Abuse and Addiction Research Programs).
What activity category was listed for this opportunity?
The activity category was listed under Education and Health.
Was cost sharing or matching required?
No. The FOA did not require cost sharing or matching funds.
How much total funding was estimated to be available?
The estimated total funding available for the FOA was $2,000,000.
When was the opportunity posted and when did it close?
The opportunity was posted on February 4, 2014. The original and current closing date was July 31, 2014. The archive date was August 31, 2014.
What was the "created" date listed for the opportunity?
The opportunity was created on February 5, 2014.
Where can the full announcement be found?
The full announcement was available in the NIH Grants Guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-15-005.html.
What types of organizations were eligible to apply?
Eligibility was broad and included nonprofits (with and without 501(c)(3) status), public and private institutions of higher education, small businesses, for-profit organizations (other than small businesses), and government entities (including city/township, county, state, and special district governments), as well as public housing authorities/Indian housing authorities.
Were historically underserved or mission-specific institutions explicitly included?
Yes. The FOA explicitly included organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also included faith-based and community-based organizations, tribal organizations, and U.S. territories or possessions.
Were non-U.S. entities and foreign institutions eligible?
Yes. Non-U.S. entities and foreign institutions were eligible. Non-U.S. components of U.S. organizations could apply, and foreign components (as defined by NIH policy) were allowed.
What was the overall emphasis of the FOA in terms of innovation versus feasibility?
The FOA sought proposals that were bold and creative while also methodologically sound and ready to be executed as full research projects, supported by a rigorous R01-style application with justification and preliminary data.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing the announcement or linking to it, the listed point of contact was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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Applicants who have applied for this opportunity (RFA DA 15 005) also looked into and applied for these:
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| Prevention and Treatment of Substance Using Populations with or at Risk for HCV (R01) Apply for PA 14 137 Funding Number: PA 14 137 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Community Partnerships to Advance Research (CPAR) (R21) Apply for PA 14 141 Funding Number: PA 14 141 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Community Partnerships to Advance Research (CPAR) (R01) Apply for PA 14 142 Funding Number: PA 14 142 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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