Opportunity Information: Apply for PAS 07 381
Apply for PAS 07 381
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Advancing Novel Science in Women s Health Research (ANSWHR) R21" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.121 Oral Diseases and Disorders Research 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.226 Research on Healthcare Costs, Quality and Outcomes 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research 93.879 Medical Library Assistance 93.989 International Research and Research Training.
- This funding opportunity was created on Dec 5, 2008 and posted on Jun 11, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $2,000,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education City or township governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) County governments Private institutions of higher education State governments Public housing authorities/Indian housing authorities Special district governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Advancing Novel Science in Women's Health Research (ANSWHR) R21 opportunity (Funding Opportunity Number PAS-07-381) is an NIH discretionary grant program led by the Office of Research on Women's Health (ORWH) with multiple NIH Institutes and Centers participating as co-sponsors. Its core aim is to spark bold, innovative, and interdisciplinary early-stage research that can open up new directions in women's health and in understanding sex and gender differences in health and disease. The program is grounded in a clear scientific motivation: research has increasingly shown that studying conditions that uniquely affect women, and analyzing research findings separately for females and males when appropriate, can substantially improve scientific accuracy, clinical relevance, and health outcomes. In other words, the FOA is designed to push the field beyond one-size-fits-all assumptions and toward research that more precisely accounts for biological sex and gender-related factors.
This FOA explicitly emphasizes novelty and cross-disciplinary collaboration. ORWH signals strong interest in encouraging extramural researchers to propose new, integrative projects that examine how sex and gender influence women's health, including mechanisms, risk factors, disease presentation, progression, response to treatment, prevention strategies, and health outcomes. At the same time, the announcement leaves the door wide open: proposals are invited across the full range of women's health research topics and sex/gender difference research, not only those narrowly focused on a single disease area. That broad scope is reinforced by the long list of participating CFDA research areas, spanning environmental health, mental health, substance use, cancer, cardiovascular and pulmonary disease, arthritis and skin conditions, infectious diseases, genomics, child health and development, aging, vision, nursing research, sleep disorders, health services and outcomes research, and complementary/integrative health, among others. The practical takeaway is that investigators working in many biomedical, behavioral, clinical, translational, and population-health domains can potentially align their projects with this opportunity if they make women's health and/or sex/gender considerations central to the scientific question.
From an administrative standpoint, this is an NIH grant using the R21 activity mechanism, which is generally intended for exploratory and developmental research that may be higher risk but also potentially high reward. The funding instrument is a grant, and the opportunity is categorized under multiple activity areas including education, environment, health, income security, and social services, reflecting the broad ways women's health questions can intersect with both biomedical science and real-world health systems. The listed award ceiling is up to $2,000,000, and there is no cost-sharing or matching requirement, meaning applicants are not expected to provide non-federal matching funds as a condition of receiving an award.
Eligibility is notably expansive. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses and other for-profit entities (including those other than small businesses), state, county, city or township governments, special district governments, public housing authorities/Indian housing authorities, independent school districts, and Native American tribal governments and organizations. The FOA also clarifies that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations are also eligible. This wide eligibility range suggests NIH and ORWH wanted to encourage participation from many kinds of research and community settings, including those well positioned to study sex/gender differences through clinical cohorts, public health data, community-engaged research, or specialized laboratory capabilities.
The opportunity was posted June 11, 2007, with multiple receipt dates (rather than a single deadline), indicating it was structured to accept applications on recurring submission cycles during the active period. The archive date is February 7, 2010, which means the specific announcement is no longer active, but it remains useful as a reference for understanding ORWH priorities and NIH expectations around sex/gender analysis and women's health innovation during that period. The full announcement is linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PAS-07-381.html, and the contact listed for access or technical issues is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
Overall, PAS-07-381 can be understood as a targeted push by ORWH and partner NIH Institutes and Centers to accelerate fresh, potentially paradigm-shifting research on women's health and sex/gender differences, with an emphasis on interdisciplinary approaches and on designing studies in ways that properly account for differences between females and males when scientifically justified.
Frequently Asked Questions (FAQs)
What is the Advancing Novel Science in Women's Health Research (ANSWHR) R21 opportunity?
The Advancing Novel Science in Women's Health Research (ANSWHR) R21 is an NIH discretionary grant opportunity led by the Office of Research on Women's Health (ORWH), with multiple NIH Institutes and Centers participating as co-sponsors. It is associated with Funding Opportunity Number (FOA) PAS-07-381.
What is the main goal of PAS-07-381?
The core aim is to spark bold, innovative, and interdisciplinary early-stage research that can open up new directions in women's health and in understanding sex and gender differences in health and disease.
What kinds of research does this FOA emphasize?
This FOA emphasizes novelty and cross-disciplinary collaboration, encouraging integrative projects that examine how sex and gender influence women's health. Examples of encouraged angles include mechanisms, risk factors, disease presentation, progression, response to treatment, prevention strategies, and health outcomes, as long as women's health and/or sex/gender considerations are central to the scientific question.
Is this opportunity limited to a single disease area or a narrow topic?
No. The announcement explicitly invites proposals across the full range of women's health research topics and sex/gender difference research, rather than limiting applications to one disease area.
Why does the FOA stress sex and gender analysis?
The scientific motivation described in the FOA is that studying conditions that uniquely affect women, and analyzing findings separately for females and males when appropriate, can improve scientific accuracy, clinical relevance, and health outcomes. The FOA is designed to move research beyond one-size-fits-all assumptions by accounting for biological sex and gender-related factors.
What NIH grant mechanism does PAS-07-381 use?
The FOA uses the NIH R21 activity mechanism, which is generally intended for exploratory and developmental research that may be higher risk but potentially high reward.
What is the funding instrument for this opportunity?
The funding instrument is a grant.
What is the maximum award amount listed for this FOA?
The listed award ceiling is up to $2,000,000.
Is cost sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement, meaning applicants are not expected to provide non-federal matching funds as a condition of receiving an award.
What research domains or topic areas could potentially fit this FOA?
The scope is broad and spans many biomedical, behavioral, clinical, translational, and population-health domains. The participating CFDA research areas listed include (among others) environmental health, mental health, substance use, cancer, cardiovascular and pulmonary disease, arthritis and skin conditions, infectious diseases, genomics, child health and development, aging, vision, nursing research, sleep disorders, health services and outcomes research, and complementary/integrative health.
Who leads the program and who participates as sponsors?
The program is led by the NIH Office of Research on Women's Health (ORWH) and includes multiple NIH Institutes and Centers as participating co-sponsors.
What types of organizations are eligible to apply?
Eligibility is expansive. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, other for-profit entities (including those other than small businesses), and various government entities (state, county, city or township governments, special district governments, public housing authorities/Indian housing authorities, and independent school districts).
Are tribal governments and tribal organizations eligible?
Yes. Native American tribal governments and organizations are listed as eligible applicants.
Are foreign institutions eligible to apply?
Yes. The FOA clarifies that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The FOA notes that eligible federal agencies may apply.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly states that faith-based or community-based organizations are eligible.
When was the opportunity posted?
The opportunity was posted on June 11, 2007.
Does PAS-07-381 have a single deadline?
No. The FOA indicates multiple receipt dates rather than a single deadline, meaning applications were structured around recurring submission cycles during the active period.
Is this specific FOA still active?
No. The archive date is February 7, 2010, which indicates the specific announcement is no longer active.
Where can the full FOA text be found?
The full announcement is available through NIH at http://grants.nih.gov/grants/guide/pa-files/PAS-07-381.html.
Who is the listed contact for access or technical issues related to the FOA?
The contact listed for access or technical issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the practical takeaway for investigators considering fit?
Investigators across many research settings and disciplines may be able to align with this opportunity if women's health and/or sex/gender considerations are central to the scientific question and the proposed work is novel, exploratory, and well suited to an interdisciplinary, early-stage R21-style project.
How does the FOA describe the kind of impact it aims to create?
It is positioned as a targeted push to accelerate fresh, potentially paradigm-shifting research in women's health and sex/gender differences, with an emphasis on interdisciplinary approaches and on designing studies that properly account for differences between females and males when scientifically justified.
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