Opportunity Information: Apply for PA 16 031
Apply for PA 16 031
- The HHS-NIH11 in the health, income security and social services sector is offering a public funding opportunity titled "Advancing Understanding, Prevention and Management of Infections Transmitted from Women to their Infants (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865,.
- This funding opportunity was created on Nov 05, 2015 and posted on Nov 05, 2015.
- Applicants must submit their applications by Sep 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The grant opportunity titled "Advancing Understanding, Prevention and Management of Infections Transmitted from Women to their Infants (R21)" (Funding Opportunity Number PA-16-031) is a National Institutes of Health (NIH) discretionary grant designed to encourage early-stage, exploratory research on perinatal infections that pass from mothers to infants. Administered under HHS-NIH11 and aligned with CFDA 93.865, the program uses the R21 mechanism, which is generally intended to support novel, high-impact ideas, pilot studies, and proof-of-concept work that can generate the preliminary evidence needed for larger future projects. The overall goal is to move the field forward by supporting investigations that clarify how non-HIV infections are transmitted from women to their offspring and how those infections can be prevented, detected earlier, or managed more effectively to improve maternal and infant health outcomes.
A central emphasis of the FOA is on non-HIV infectious diseases that are transmitted during key perinatal windows: pregnancy, labor and delivery, and breastfeeding. The scope is intentionally broad and includes translational research (work that helps bridge basic discoveries into clinical tools or strategies), epidemiologic studies (research that examines patterns, risk factors, burden, and determinants in populations), and clinical studies and trials (research that evaluates interventions, diagnostics, prevention approaches, or clinical management strategies in real-world or controlled clinical contexts). In practical terms, the announcement aims to stimulate studies that deepen scientific understanding of transmission pathways and risk factors, identify opportunities for prevention, and ultimately improve clinical outcomes for infants exposed to or infected by pathogens acquired from the mother. The National Institute of Child Health and Human Development (NICHD) highlights a commitment to high-priority perinatal infections, signaling interest in research that can meaningfully inform care guidelines, public health interventions, or future therapeutic development.
The opportunity is open to a wide range of applicant organizations, reflecting the NIH goal of encouraging participation across academic, clinical, governmental, nonprofit, and private-sector settings. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other Native American tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations other than small businesses; small businesses; and other entities as further clarified in the FOA. This breadth of eligibility supports multidisciplinary teams and partnerships that may be needed to address perinatal infection challenges, such as collaborations between obstetric and pediatric clinical sites, public health departments, diagnostic developers, and academic research groups.
From a funding and administrative standpoint, the award instrument is a grant under the health-related funding activity category. The listed award ceiling is $200,000, which aligns with the R21 model of supporting smaller, exploratory efforts rather than large-scale definitive trials. While the source data does not specify the number of expected awards, the structure and intent indicate a competitive program aimed at catalyzing multiple innovative projects rather than funding a single large initiative. Key dates in the source data show the FOA was created and posted on November 5, 2015, and the closing date listed is September 7, 2019 (both original and current closing dates match in the provided data). Even though those dates indicate the specific posting period captured here, the summary of the FOA itself remains useful for understanding the research priorities and the kinds of projects NICHD sought to stimulate under this mechanism.
In plain terms, this funding opportunity is about improving outcomes for mothers and babies by tackling infections that can be passed from mother to child around the time of birth and early infancy, excluding HIV. It encourages researchers to generate actionable knowledge about how these infections spread, who is at greatest risk, what prevention methods work best, and how clinical management can be improved. The intended impact is stronger evidence that can lead to better screening or diagnostic strategies, more effective preventive measures, improved treatment approaches, and ultimately fewer infections and complications in newborns and infants.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Advancing Understanding, Prevention and Management of Infections Transmitted from Women to their Infants (R21)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PA-16-031.
Which agency is offering this grant?
This is a National Institutes of Health (NIH) discretionary grant administered under HHS-NIH11.
Which NIH institute is highlighted in this opportunity?
The National Institute of Child Health and Human Development (NICHD) is specifically highlighted and signals interest in high-priority perinatal infections.
What is the CFDA/assistance listing number associated with this program?
The opportunity is aligned with CFDA 93.865.
What type of grant mechanism is used?
The program uses the NIH R21 mechanism, which is generally intended for early-stage, exploratory research such as novel, high-impact ideas, pilot studies, and proof-of-concept work.
What is the overall purpose of this FOA?
The goal is to move the field forward by supporting research that clarifies how non-HIV infections are transmitted from women to their infants and how these infections can be prevented, detected earlier, or managed more effectively to improve maternal and infant health outcomes.
What kinds of infections are the focus of this funding opportunity?
The central emphasis is on non-HIV infectious diseases transmitted from women to their offspring during the perinatal period.
Is HIV included in the scope of this FOA?
No. The opportunity emphasizes non-HIV infections.
During which time periods does the FOA consider transmission from mother to infant?
The FOA focuses on key perinatal windows when transmission can occur, including pregnancy, labor and delivery, and breastfeeding.
What research areas or approaches are encouraged?
The scope is intentionally broad and includes translational research, epidemiologic studies, and clinical studies and trials aimed at understanding transmission pathways and risk factors, identifying prevention opportunities, and improving clinical outcomes.
Does the FOA support translational research?
Yes. Translational research is included, described as work that helps bridge basic discoveries into clinical tools or strategies.
Does the FOA support epidemiologic research?
Yes. Epidemiologic studies are included, such as research examining patterns, risk factors, burden, and determinants in populations.
Does the FOA support clinical studies or clinical trials?
Yes. Clinical studies and trials are included, such as research that evaluates interventions, diagnostics, prevention approaches, or clinical management strategies in clinical contexts.
What types of outcomes or impacts is the program aiming for?
The intended impact is stronger evidence that can lead to better screening or diagnostic strategies, more effective preventive measures, improved treatment or management approaches, and ultimately fewer infections and complications in newborns and infants.
How does this FOA describe the kind of work an R21 is meant to support?
It is geared toward smaller, exploratory efforts that can generate preliminary evidence needed for larger future projects, including pilot and proof-of-concept studies.
What is the award instrument for this opportunity?
The award instrument is a grant under the health-related funding activity category.
What is the maximum award amount (award ceiling) listed?
The listed award ceiling is $200,000.
Is the expected number of awards provided?
No. The provided information does not specify the number of expected awards.
Who is eligible to apply?
Eligibility is broad and includes government entities (state, county, city or township, and special district governments), independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, federally recognized Native American tribal governments and other Native American tribal organizations, public housing authorities and Indian housing authorities, nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories), for-profit organizations other than small businesses, small businesses, and other entities as further clarified in the FOA.
Are small businesses eligible?
Yes. Small businesses are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are listed as eligible, and small businesses are also listed as eligible.
Are nonprofits eligible even if they do not have 501(c)(3) status?
Yes. Nonprofit organizations with or without 501(c)(3) status are listed as eligible (with exclusions noted in the provided summary for institutions of higher education in those nonprofit categories).
Are universities and colleges eligible to apply?
Yes. Both public/state-controlled institutions of higher education and private institutions of higher education are listed as eligible.
Are tribal governments or tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are listed as eligible.
Are local and state government entities eligible?
Yes. State, county, city or township, and special district governments are listed as eligible, as well as independent school districts.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Does the FOA encourage collaborative or multidisciplinary work?
Yes. The broad eligibility is described as supporting multidisciplinary teams and partnerships that may be needed to address perinatal infection challenges (for example, collaborations across obstetric and pediatric clinical sites, public health departments, diagnostic developers, and academic research groups).
What is the main scientific focus in practical terms?
The announcement aims to stimulate studies that deepen understanding of transmission pathways and risk factors, identify opportunities for prevention, and improve clinical outcomes for infants exposed to or infected by pathogens acquired from the mother.
When was this FOA created and posted?
The key dates provided indicate it was created and posted on November 5, 2015.
What is the closing date listed for this opportunity in the provided information?
The closing date listed is September 7, 2019 (the original and current closing dates match in the provided data).
Is this FAQ confirming whether the opportunity is currently open?
No. The provided information includes historical posting and closing dates, but it does not state current availability beyond those dates.
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Applicants who have applied for this opportunity (PA 16 031) also looked into and applied for these:
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| Advancing Understanding, Prevention, and Management of Infections Transmitted from Women to their Infants (R01) Apply for PA 16 032 Funding Number: PA 16 032 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Oocyte Mitochondrial Function in Relation to Fertility, Aging, and Mitochondrial Diseases (R01) Apply for PA 16 088 Funding Number: PA 16 088 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Archiving and Documenting Child Health and Human Development Data Sets (R03) Apply for PAR 16 149 Funding Number: PAR 16 149 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Animal-Assisted Interventions for Special Populations (R21) Apply for RFA HD 17 015 Funding Number: RFA HD 17 015 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Animal-Assisted Interventions for Special Populations (R03) Apply for RFA HD 17 014 Funding Number: RFA HD 17 014 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R21) Apply for PAR 16 195 Funding Number: PAR 16 195 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $200,000 |
| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R01) Apply for PAR 16 196 Funding Number: PAR 16 196 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03) Apply for PAR 16 197 Funding Number: PAR 16 197 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $50,000 |
| Preclinical Research on Model Organisms to Predict Treatment Outcomes for Disorders Associated with Intellectual and Developmental Disabilities (R01) Apply for PAR 16 215 Funding Number: PAR 16 215 Agency: HHS-NIH11 Category: Health, Income Security and Social Services Funding Amount: $499,999 |
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