Opportunity Information: Apply for RFA AG 13 017
Apply for RFA AG 13 017
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Age Related Changes in Osteoimmunology (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Nov 13, 2012 and posted on Nov 13, 2012.
- Applicants must submit their applications by Feb 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $125,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments State governments Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Age Related Changes in Osteoimmunology (R01) funding opportunity (RFA-AG-13-017) was released by the National Institute on Aging (NIA) within the National Institutes of Health to support research that expands what is known about how aging alters the relationship between the immune system and the skeleton. The central idea is that osteoimmunology, the study of immune-bone cross talk, has largely been built on experiments done in young mice (often under 6 months old). While those models are useful for basic mechanisms, they do not capture immune senescence or the age-associated remodeling of the bone marrow environment, so they can miss the biology most relevant to older adults where bone loss and immune dysfunction commonly occur together.
The FOA specifically encourages animal model research that tests how age-related declines in immune function affect bone homeostasis, and also the reverse direction: how aging-related changes in the bone marrow niche and skeletal microenvironment reshape immune behavior and immune-bone interactions. In practical terms, the NIA is looking for studies that move beyond young-animal assumptions and directly compare younger versus aged animals to identify mechanisms that only appear, worsen, or meaningfully change with age. The motivation is clinical relevance: in humans, disrupted immune-skeletal balance is frequently seen in older populations, where immune aging and loss of bone homeostasis co-exist and may reinforce one another in ways that drive disease.
This is an R01 research project grant, meaning it is intended for substantial, hypothesis-driven projects rather than small pilot efforts. It is framed as a vehicle for investigators already working in osteoimmunology to extend or broaden their ongoing lines of research into aging contexts, rather than starting from scratch. The opportunity was categorized as discretionary grant funding in the health area, under CFDA 93.866 (Aging Research), and it stated there was no cost sharing or matching requirement.
From a funding and timing standpoint, the FOA listed an estimated total funding amount of $1,000,000 and an award ceiling of $125,000. It was posted on November 13, 2012, with an original and current closing date of February 7, 2013, and an archive date of March 10, 2013, indicating it is no longer active but remains available as a record of the solicitation.
Eligibility was broad and included many common applicant types across academia, government, nonprofit, and industry. Eligible applicants included public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses), and multiple levels of government (state, county, city/township, special district, independent school districts), as well as public housing authorities/Indian housing authorities. The FOA also explicitly included a wide range of mission-based and underserved-serving institutions and organizations such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs, along with faith-based or community-based organizations and eligible federal agencies. Importantly, non-U.S. entities were eligible: foreign organizations and foreign institutions could apply, non-domestic components of U.S. organizations were eligible, and foreign components were allowed as defined by NIH policy.
Operationally, the announcement pointed applicants to the full FOA text on the NIH grants website and provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues. Overall, the opportunity was designed to push osteoimmunology toward experiments and interpretations that reflect the realities of aging, using animal models to uncover how immunologic aging and skeletal aging intersect, and how those interactions may help explain why immune and bone disorders are so prevalent and interconnected in older adults.
Frequently Asked Questions (FAQs)
What is the Age Related Changes in Osteoimmunology (R01) funding opportunity?
It is a National Institutes of Health (NIH) funding opportunity released by the National Institute on Aging (NIA) titled "Age Related Changes in Osteoimmunology (R01)" with FOA number RFA-AG-13-017. It supports research that expands what is known about how aging alters the relationship between the immune system and the skeleton (immune-bone cross talk).
Which NIH institute released this opportunity?
The opportunity was released by the National Institute on Aging (NIA) within the NIH.
What type of grant mechanism is this?
This is an R01 research project grant, intended for substantial, hypothesis-driven research projects rather than small pilot efforts.
What is the scientific focus of this FOA?
The FOA focuses on osteoimmunology, specifically how aging changes immune-bone interactions. It emphasizes that much of the field has been built from experiments in young mice (often under 6 months old), which may not capture immune senescence or age-associated remodeling of the bone marrow environment.
Why does the FOA emphasize aged animals instead of only young-animal models?
The FOA highlights that young-animal models can miss biology most relevant to older adults because they do not reflect immune aging (immune senescence) or age-related changes in the bone marrow niche and skeletal microenvironment. The goal is to improve clinical relevance to older populations where bone loss and immune dysfunction often occur together.
What kinds of studies does the FOA encourage?
The FOA specifically encourages animal model research that directly examines age-related effects by comparing younger versus aged animals to identify mechanisms that only appear, worsen, or meaningfully change with age.
Does the FOA support research on how immune aging affects bone?
Yes. It encourages studies that test how age-related declines in immune function affect bone homeostasis.
Does the FOA also support the reverse direction (bone influencing immune behavior)?
Yes. The FOA also encourages research on how aging-related changes in the bone marrow niche and skeletal microenvironment reshape immune behavior and immune-bone interactions.
Is this opportunity intended for new investigators starting in osteoimmunology?
The FOA is framed as a vehicle for investigators already working in osteoimmunology to extend or broaden their ongoing lines of research into aging contexts, rather than starting from scratch.
What is the overall motivation or public health rationale described in the FOA?
The motivation is clinical relevance: disrupted immune-skeletal balance is frequently seen in older populations, where immune aging and loss of bone homeostasis co-exist and may reinforce one another in ways that contribute to disease.
What is the CFDA number and program area for this opportunity?
The opportunity is listed under CFDA 93.866 (Aging Research) and categorized as discretionary grant funding in the health area.
Is cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
How much total funding was estimated to be available under this FOA?
The FOA listed an estimated total funding amount of $1,000,000.
What was the award ceiling?
The FOA listed an award ceiling of $125,000.
When was the FOA posted, and what were the key dates?
It was posted on November 13, 2012. The original and current closing date was February 7, 2013. The archive date was March 10, 2013.
Is this funding opportunity currently active?
No. The closing and archive dates indicate the FOA is no longer active, though it remains available as a record of the solicitation.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (including small businesses); and multiple levels of government (state, county, city/township, special district, independent school districts). The FOA also listed public housing authorities/Indian housing authorities as eligible.
Were mission-based and underserved-serving institutions included in the eligibility list?
Yes. The FOA explicitly included institutions and organizations such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs. It also included faith-based or community-based organizations and eligible federal agencies.
Were foreign (non-U.S.) entities eligible to apply?
Yes. The FOA stated that foreign organizations and foreign institutions could apply. It also allowed non-domestic components of U.S. organizations and foreign components as defined by NIH policy.
Where did the FOA direct applicants for full details and official instructions?
The announcement pointed applicants to the full FOA text on the NIH grants website for complete requirements and instructions.
Who was listed as a contact for access or linking issues?
For access or linking issues, the FOA referenced contacts through the NIH Office of Extramural Research (OER) webmaster.
What is the central premise behind the research need described in this FOA?
The central premise is that osteoimmunology has largely relied on young-mouse experiments, which may not capture immune senescence and age-related remodeling of the bone marrow environment. The FOA seeks research that reflects aging biology more directly to better understand immune and skeletal disorders common in older adults.
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