Opportunity Information: Apply for PA 10 179
Apply for PA 10 179
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Aging Studies in the Pulmonary System (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research 93.866 Aging Research.
- This funding opportunity was created on Apr 28, 2010 and posted on Apr 28, 2010.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Small businesses Native American tribal governments (Federally recognized) State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH funding opportunity "Aging Studies in the Pulmonary System (R01)" (Funding Opportunity Number PA-10-179) is a discretionary research grant announcement sponsored by the National Institute on Aging (NIA) together with the National Heart, Lung, and Blood Institute (NHLBI). It is designed to support research that explains how the lung and broader pulmonary system change with age, focusing on age-associated shifts in pulmonary physiology, pathology, and overall function. A central theme of the program is the connection between normal biological aging of the respiratory system and the respiratory conditions and diseases that are especially common in older adults. The intent is to fund studies that clarify why pulmonary function progressively declines over time and which mechanisms drive that decline, with an emphasis on producing knowledge that could ultimately strengthen prevention strategies and improve clinical management for aging populations.
The scientific scope is broad and intentionally inclusive of basic, clinical, and translational research. On the basic science side, the FOA encourages investigations into molecular and cellular mechanisms of pulmonary aging, which can include processes that affect lung structure and repair, immune and inflammatory signaling in older lungs, tissue remodeling, extracellular matrix changes, oxidative stress responses, cellular senescence pathways, mitochondrial and metabolic changes, and age-related alterations in host defense and susceptibility to injury. On the clinical and translational side, the FOA supports work that connects these mechanisms to measurable functional outcomes and real-world disease risk in older people, aiming to bridge mechanistic biology with the kinds of pulmonary impairments and respiratory illnesses that become more frequent or severe with advancing age. The overall expectation is that stronger mechanistic understanding will create clearer targets for intervention and better-informed approaches to monitoring, preventing, or treating pulmonary disease in later life.
A notable feature of the announcement is that it welcomes a wide range of research approaches and model systems. Projects may be conducted using in vitro systems (for example, cell culture models relevant to airway or alveolar biology), animal models that allow controlled testing of aging-related pulmonary changes, and/or studies involving human participants. NIH signals that each of these approaches is of significant interest, which effectively encourages applicants to use the methods best suited to their research questions, including multidisciplinary designs that integrate mechanistic experiments with human phenotyping or clinical observations. Because the FOA is focused on physiological mechanisms underlying functional decline, competitive applications would typically be expected to define clear aging-related endpoints, connect biological measures to pulmonary function or disease-relevant outcomes, and present a coherent plan for how the study will advance understanding of pulmonary aging rather than only describing disease in older populations.
The mechanism of support is the NIH R01 Research Project Grant, meaning awards are intended for substantial, investigator-initiated research projects with well-developed aims and a rigorous approach. The announcement notes that awards depend on the availability of funds and on receiving a sufficient number of meritorious applications, which is standard NIH language indicating there is no guaranteed number of awards and that funding decisions will depend on both scientific merit and budget conditions.
From an administrative and eligibility standpoint, this opportunity was posted on April 28, 2010, with an original and final closing date of May 7, 2013, and it was archived on June 7, 2013. The funding activity category is Health, and the related CFDA numbers listed are 93.838 (Lung Diseases Research) and 93.866 (Aging Research). Cost sharing or matching is not required. Eligibility is broad and includes many organization types such as public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses), state governments, U.S. territories or possessions, and tribal entities. The announcement also explicitly includes a range of institutions and organizations often highlighted for federal eligibility purposes, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, regional organizations, and non-U.S. (foreign) entities.
For applicants or interested parties seeking the full original text and administrative details, the FOA is linked through the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PA-10-179.html. The announcement also provides contact direction for technical access issues through the NIH Office of Extramural Research (OER) webmaster email address listed in the source data.
FAQs: Aging Studies in the Pulmonary System (R01) - NIH (PA-10-179)
What is the NIH funding opportunity "Aging Studies in the Pulmonary System (R01)" (PA-10-179)?
PA-10-179 is a discretionary NIH research grant announcement for the R01 mechanism that supports studies aimed at explaining how the lung and broader pulmonary system change with age. It prioritizes research on age-associated shifts in pulmonary physiology, pathology, and overall function, and how normal biological aging relates to respiratory conditions and diseases that are common in older adults.
Which NIH institutes sponsor this opportunity?
This funding opportunity is sponsored by the National Institute on Aging (NIA) together with the National Heart, Lung, and Blood Institute (NHLBI).
What is the main goal or theme of the program?
A central theme is the connection between normal respiratory system aging and respiratory diseases and conditions that increase in frequency or severity in older adults. The program aims to clarify why pulmonary function progressively declines over time and which mechanisms drive that decline, with the longer-term intent of informing prevention strategies and improving clinical management for aging populations.
What kinds of research does the FOA support (basic, clinical, translational)?
The scientific scope is broad and includes basic, clinical, and translational research. The FOA encourages mechanistic biology as well as work that links biological mechanisms to functional outcomes and disease risk in older people.
What basic science topics are considered responsive under this FOA?
On the basic science side, the FOA highlights molecular and cellular mechanisms of pulmonary aging, including topics such as lung structure and repair, immune and inflammatory signaling in older lungs, tissue remodeling, extracellular matrix changes, oxidative stress responses, cellular senescence pathways, mitochondrial and metabolic changes, and age-related alterations in host defense and susceptibility to injury.
What clinical or translational topics are encouraged?
On the clinical and translational side, the FOA supports studies that connect aging-related mechanisms to measurable functional outcomes and disease-relevant risk in older people, with an emphasis on bridging mechanistic biology to pulmonary impairments and respiratory illnesses that become more common or more severe with advancing age.
Does this opportunity focus only on disease in older adults?
No. While age-related diseases and conditions are part of the motivation, the FOA emphasizes understanding physiological mechanisms underlying functional decline with age. Competitive projects would be expected to advance understanding of pulmonary aging, rather than only describing disease patterns in older populations.
What types of study approaches and model systems are allowed?
The announcement welcomes a wide range of research approaches and model systems, including in vitro systems (such as cell culture models relevant to airway or alveolar biology), animal models for controlled testing of aging-related pulmonary changes, and studies involving human participants. Multidisciplinary designs that integrate mechanistic experiments with human phenotyping or clinical observations are also aligned with the FOA's intent.
What makes an application competitive based on the description provided?
Based on the FOA description, competitive applications would typically define clear aging-related endpoints, connect biological measures to pulmonary function or disease-relevant outcomes, and present a coherent plan showing how the study will advance understanding of pulmonary aging mechanisms that underlie functional decline.
What is the funding mechanism for this opportunity?
The mechanism of support is the NIH R01 Research Project Grant, intended for substantial, investigator-initiated research projects with well-developed aims and a rigorous approach.
Are awards guaranteed, and what factors affect funding?
Awards are not guaranteed. The FOA notes that awards depend on the availability of funds and the receipt of a sufficient number of meritorious applications. This indicates funding decisions depend on both scientific merit and budget conditions.
When was this opportunity posted, and what are the closing and archive dates?
The opportunity was posted on April 28, 2010. The original and final closing date was May 7, 2013. It was archived on June 7, 2013.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
What is the funding activity category?
The funding activity category listed is Health.
Which CFDA numbers are associated with this opportunity?
The related CFDA numbers listed are 93.838 (Lung Diseases Research) and 93.866 (Aging Research).
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses), state governments, U.S. territories or possessions, and tribal entities. The FOA also explicitly includes certain institution types commonly highlighted for federal eligibility purposes, such as HBCUs, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, regional organizations, and non-U.S. (foreign) entities.
Are non-U.S. (foreign) entities eligible under this FOA?
Yes. The eligibility section explicitly includes non-U.S. (foreign) entities.
Where can applicants find the full official FOA text?
The FOA is available through the NIH grants site at: http://grants.nih.gov/grants/guide/pa-files/PA-10-179.html
Who should be contacted for technical access issues related to the FOA?
The announcement provides contact direction for technical access issues through the NIH Office of Extramural Research (OER) webmaster email address listed in the source data.
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