Opportunity Information: Apply for RFA HS 10 008
Apply for RFA HS 10 008
- The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "AHRQ Developing Prospective Practice based Comparative Effectiveness Research Clinical Registries Orthopedic Devices, Drugs, and Procedures (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes.
- This funding opportunity was created on Jul 6, 2009 and posted on Jul 6, 2009.
- Applicants must submit their applications by Sep 23, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: City or township governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Private institutions of higher education Public and State controlled institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Indian/Native American Tribal Governments (Other than Federally Recognized).
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Opportunity Summary:
The Agency for Healthcare Research and Quality (AHRQ) announced this grant opportunity to build a prospective, practice-based clinical registry focused on orthopedic devices, drugs, and procedures using the P50 center-style grant mechanism. The central idea is to create a durable, scalable data and research infrastructure that can systematically capture real-world clinical and outcomes information across multiple sites, then use that infrastructure to run rigorous prospective studies. AHRQ is aiming for a registry that does more than collect data; it is meant to function as a collaborative research platform capable of producing credible evidence about comparative effectiveness and safety, especially around implantable orthopedic devices and related orthopedic care.
AHRQ positions a broad, practice-based orthopedic registry as one of the most productive ways to close evidence gaps on both short-term and long-term benefits and harms of orthopedic interventions. In practical terms, the registry is expected to support multi-center participation across a wide provider network, not just major academic medical centers. The announcement explicitly encourages inclusion of community-based and smaller practice sites alongside high-volume institutions, reflecting a goal of improving generalizability and ensuring the findings reflect the range of real-world orthopedic practice settings. The registry is also intended to serve as a model and foundation for other national registries covering medical devices and procedures, meaning applicants are implicitly expected to think about governance, standardization, data quality, interoperability, and long-term sustainability from the start.
This opportunity is tied to AHRQ's Effective Health Care (EHC) Program, which was authorized under Section 1013 of the Medicare Prescription Drug, Improvement, and Modernization Act (MMA) (42 USC 299b-7). That authority supports federal investment in comparative effectiveness research, and this funding announcement is one way AHRQ sought to advance that mission. The registry effort is framed as infrastructure plus science: AHRQ intends to fund both the development and maintenance of the registry platform and the execution of multiple collaborative, prospective, multi-center studies using the registry as the underlying engine. The expectation is that research results will not remain academic; the registry program is supposed to actively disseminate findings and help translate evidence back into clinical practice to improve decision-making and patient outcomes.
Key administrative details reflect a single, relatively large award meant to establish a national-level resource. The funding opportunity number is RFA-HS-10-008, titled "AHRQ Developing Prospective Practice-based Comparative Effectiveness Research Clinical Registries Orthopedic Devices, Drugs, and Procedures (P50)." It is a discretionary grant in the health category under CFDA 93.226 (Research on Healthcare Costs, Quality and Outcomes). AHRQ anticipated making one award, with an estimated total funding level of $3,000,000, and there was no cost sharing or matching requirement. The announcement was posted July 6, 2009, with an original and current closing date of September 23, 2009, and an archive date of October 24, 2009.
Eligibility was broad and included public and private institutions of higher education, state and local governments (including city, county, and township governments), federally recognized and other tribal organizations, faith-based or community-based organizations, and eligible federal agencies. Overall, the announcement is best understood as a targeted investment in a national orthopedic registry that can continuously generate high-quality comparative effectiveness and safety evidence, anchored in a practice-based research collaborative, and designed to influence everyday orthopedic care through systematic dissemination of results.
Frequently Asked Questions (FAQs)
What is this grant opportunity?
This is an Agency for Healthcare Research and Quality (AHRQ) funding opportunity to build a prospective, practice-based clinical registry focused on orthopedic devices, drugs, and procedures using a P50 center-style grant mechanism.
What is the funding opportunity number and title?
The funding opportunity number is RFA-HS-10-008. The title is "AHRQ Developing Prospective Practice-based Comparative Effectiveness Research Clinical Registries Orthopedic Devices, Drugs, and Procedures (P50)."
Which agency is offering this funding?
The offering agency is the Agency for Healthcare Research and Quality (AHRQ).
What is the main purpose of the grant?
The main purpose is to create a durable, scalable data and research infrastructure that can systematically capture real-world clinical and outcomes information across multiple sites and use that infrastructure to run rigorous prospective studies.
What kind of registry is AHRQ aiming to support?
AHRQ is aiming for a prospective, practice-based orthopedic registry that functions as a collaborative research platform, not just a data collection system. It is intended to produce credible evidence about comparative effectiveness and safety, especially for implantable orthopedic devices and related orthopedic care.
What clinical areas does the registry focus on?
The registry is focused on orthopedic devices, drugs, and procedures.
How is "practice-based" described in the opportunity?
"Practice-based" is framed as broad, real-world participation across multiple sites and a wide provider network, not limited to major academic medical centers.
Are community-based and smaller practice sites expected to be included?
Yes. The announcement explicitly encourages inclusion of community-based and smaller practice sites alongside high-volume institutions to improve generalizability and reflect real-world orthopedic practice settings.
Is this registry intended to support research in addition to data collection?
Yes. The registry is intended to serve as infrastructure plus science: AHRQ intends to fund both the development and maintenance of the registry platform and the execution of multiple collaborative, prospective, multi-center studies using the registry.
What types of studies are expected to be conducted using the registry?
The opportunity emphasizes rigorous, prospective, multi-center studies designed to produce credible evidence on comparative effectiveness and safety.
What kinds of evidence gaps is this registry meant to address?
AHRQ positions a broad, practice-based orthopedic registry as a productive way to close evidence gaps on both short-term and long-term benefits and harms of orthopedic interventions.
Is dissemination and translation to practice part of the expectation?
Yes. The registry program is expected to actively disseminate findings and help translate evidence back into clinical practice to improve decision-making and patient outcomes.
Is the registry intended to become a national-level resource?
Yes. The administrative details and emphasis indicate a single, relatively large award meant to establish a national-level resource and a practice-based research collaborative.
Is AHRQ positioning this registry as a model for other registries?
Yes. The registry is intended to serve as a model and foundation for other national registries covering medical devices and procedures, implying attention to governance, standardization, data quality, interoperability, and long-term sustainability from the start.
What program is this opportunity tied to?
This opportunity is tied to AHRQ's Effective Health Care (EHC) Program.
What legal authority is cited for this effort?
The opportunity references Section 1013 of the Medicare Prescription Drug, Improvement, and Modernization Act (MMA) (42 USC 299b-7), which supports federal investment in comparative effectiveness research.
What is the grant mechanism?
The grant uses a P50 center-style mechanism.
What is the CFDA number and program category?
The CFDA number is 93.226, listed as Research on Healthcare Costs, Quality and Outcomes.
What is the type of grant and category?
It is a discretionary grant in the health category.
How many awards did AHRQ anticipate making?
AHRQ anticipated making one award.
What was the estimated total funding level?
The estimated total funding level was $3,000,000.
Is there a cost sharing or matching requirement?
No. The announcement stated there was no cost sharing or matching requirement.
When was the opportunity posted?
The announcement was posted on July 6, 2009.
What were the closing dates for applications?
The original and current closing date was September 23, 2009.
When was the opportunity archived?
The archive date was October 24, 2009.
Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education, state and local governments (including city, county, and township governments), federally recognized and other tribal organizations, faith-based or community-based organizations, and eligible federal agencies.
Does eligibility include tribal organizations?
Yes. Federally recognized and other tribal organizations were included in the eligibility list.
Does eligibility include faith-based and community-based organizations?
Yes. Faith-based or community-based organizations were explicitly included.
Does eligibility include state and local government entities?
Yes. State and local governments, including city, county, and township governments, were eligible.
Does eligibility include higher education institutions?
Yes. Both public and private institutions of higher education were eligible.
Does eligibility include federal agencies?
Yes. The eligibility list included eligible federal agencies.
What makes this registry different from a traditional database?
Based on the description, it is intended to operate as a collaborative research platform that can continuously generate evidence through prospective, multi-center studies, rather than serving only as a repository of collected data.
What is the overall intent of AHRQ's investment?
Overall, the opportunity is described as a targeted investment in a national orthopedic registry that can continuously generate high-quality comparative effectiveness and safety evidence and influence everyday orthopedic care through systematic dissemination of results.
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