Opportunity Information: Apply for RFA HS 13 002

  • The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes.
  • This funding opportunity was created on Sep 7, 2012 and posted on Sep 7, 2012.
  • Applicants must submit their applications by Dec 17, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 10 candidate(s).
  • Eligible applicants include: County governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) State governments City or township governments Private institutions of higher education.
  • Other Eligible Applicants include the following Indian/Native American Tribal Governments (Other than Federally Recognized).
Apply for RFA HS 13 002

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Opportunity Summary:

The AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00) is a career development grant opportunity from the Agency for Healthcare Research and Quality designed to help promising early-career researchers become independent investigators in patient-centered outcomes research, with a strong emphasis on comparative effectiveness methods. The central goal is to build and sustain a pipeline of talented researchers who can rigorously study what works best for patients in real-world health care settings, focusing on outcomes, quality, and the practical impact of care decisions. In plain terms, the program aims to move researchers from a mentored stage of training into a stable, self-directed research career where they can lead their own PCOR projects and compete successfully for future funding.

This opportunity uses the K99/R00 mechanism, which is specifically structured to support a two-stage transition. The first stage (the K99 phase) supports a mentored period in which the applicant strengthens advanced methodological skills and expands their ability to work across disciplines relevant to comparative effectiveness and patient-centered outcomes research. The second stage (the R00 phase) supports the applicant after they secure an independent research position, allowing them to launch an independent research program and establish themselves as a principal investigator. The overall design is meant to shorten the time it takes for a strong postdoctoral researcher or junior, non-tenure-track faculty member to become independently funded, while ensuring they have the sophisticated methods training and interdisciplinary exposure needed for modern PCOR.

AHRQ anticipated making about 10 awards under this funding announcement, with an estimated total pool of approximately $1.5 million allocated for the K99 phase and $3 million for the R00 phase. The announcement makes clear that the final number of awards and the total dollars actually awarded would depend on federal funding availability as well as the volume and quality of applications received, meaning strong, well-justified proposals would be essential in a competitive review environment.

From an administrative standpoint, the funding opportunity is listed as discretionary grant funding in the health category, under CFDA number 93.226 (Research on Healthcare Costs, Quality and Outcomes). It does not require cost sharing or matching. The opportunity was posted on September 7, 2012, with an original and final closing date of December 17, 2012, and it was archived on January 17, 2013. While those dates indicate this particular announcement is historical, the description captures the core intent and structure of the program and can still be useful for understanding how AHRQ and NIH-style pathway-to-independence awards are framed.

Eligibility was broad and included public and state-controlled institutions of higher education, private institutions of higher education, and several levels of government applicants such as state governments, county governments, and city or township governments. It also included Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized, as noted). The listing also references that additional eligibility details could be provided in the full announcement text, suggesting that institutional eligibility is only one piece of the picture and that applicant-level eligibility and career-stage requirements would be spelled out in the complete FOA.

For applicants or institutions needing more detail, the notice pointed to the full announcement hosted through the NIH grants system (via the provided link) and supplied NIH Office of Extramural Research (OER) webmaster contact information for technical access or linking problems.

FAQs: AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00)

What is the AHRQ PCOR Pathway to Independence Award (K99/R00)?

The AHRQ Patient Centered Outcomes Research (PCOR) Pathway to Independence Award (K99/R00) is a career development grant opportunity from the Agency for Healthcare Research and Quality. Its purpose is to help promising early-career researchers transition from mentored training into independent investigator roles in patient-centered outcomes research (PCOR), with a strong emphasis on comparative effectiveness methods.

What is the main goal of this award?

The central goal is to build and sustain a pipeline of talented researchers who can rigorously study what works best for patients in real-world health care settings. The focus is on outcomes, quality, and the practical impact of care decisions, with an intended outcome of moving researchers into stable, self-directed research careers where they can lead PCOR projects and compete for future funding.

What does "patient-centered outcomes research" mean in this context?

Based on the announcement description, PCOR here refers to research that evaluates health care decisions and interventions in terms of outcomes and quality that matter in real-world settings, with an emphasis on determining what works best for patients and informing practical care decisions.

What does "comparative effectiveness" mean in this program description?

The opportunity emphasizes comparative effectiveness methods, meaning the research and training supported are intended to strengthen the ability to compare health care options and determine which approaches work best, for which patients, and under real-world conditions, using rigorous methods.

What is the K99/R00 mechanism?

The K99/R00 is a two-stage pathway-to-independence structure. It is designed to support a transition from a mentored phase (K99) into an independent phase (R00) once the awardee secures an independent research position.

What happens during the K99 (mentored) phase?

The K99 phase supports a mentored period in which the applicant strengthens advanced methodological skills and expands their ability to work across disciplines relevant to comparative effectiveness and patient-centered outcomes research.

What happens during the R00 (independent) phase?

The R00 phase supports the applicant after they secure an independent research position. It is intended to help the awardee launch an independent research program and establish themselves as a principal investigator in PCOR.

Why is the award structured in two phases?

The two-phase design is meant to shorten the time it takes for a strong postdoctoral researcher or junior, non-tenure-track faculty member to become independently funded, while still ensuring they receive sophisticated methods training and interdisciplinary exposure needed for modern PCOR.

Who is this award intended to help?

The description indicates it is intended for promising early-career researchers, specifically referencing a pathway for strong postdoctoral researchers or junior, non-tenure-track faculty members to move from mentored development into independent research careers.

How many awards did AHRQ anticipate making?

AHRQ anticipated making about 10 awards under this funding announcement, with the final number dependent on federal funding availability and the volume and quality of applications received.

How much funding was estimated for the program?

The announcement estimated an overall pool of approximately $1.5 million allocated for the K99 phase and $3 million for the R00 phase. The actual amounts awarded could vary depending on federal funding availability and application volume/quality.

Is this a competitive funding opportunity?

Yes. The announcement notes that award counts and dollars depend on funding availability and the volume and quality of applications received, implying a competitive review environment where strong, well-justified proposals are important.

What type of funding is this categorized as?

It is listed as discretionary grant funding in the health category.

What is the CFDA number for this opportunity?

The opportunity is listed under CFDA number 93.226, titled "Research on Healthcare Costs, Quality and Outcomes."

Does this opportunity require cost sharing or matching funds?

No. The announcement states that cost sharing or matching is not required.

When was this funding opportunity posted and when did it close?

It was posted on September 7, 2012. The original and final closing date was December 17, 2012.

Is this funding announcement still active?

No. The listing indicates it was archived on January 17, 2013, and the dates show it is historical.

If it is archived, why might it still be useful?

Even though the specific announcement is historical, the description captures the core intent and structure of the program, and it can be useful for understanding how AHRQ and NIH-style pathway-to-independence awards are framed.

What types of institutions were eligible to apply?

Eligibility included public and state-controlled institutions of higher education, private institutions of higher education, and multiple levels of government applicants such as state governments, county governments, and city or township governments. It also included Native American tribal governments (federally recognized) and tribal organizations (including those other than federally recognized, as noted).

Were there any notes about additional eligibility requirements?

Yes. The listing notes that additional eligibility details could be provided in the full announcement text, indicating that institutional eligibility is only part of the eligibility picture and that applicant-level eligibility and career-stage requirements would be spelled out in the complete FOA.

Where could applicants find the full announcement details?

The notice pointed to the full announcement hosted through the NIH grants system via the provided link in the original listing.

Who was listed as a contact for technical issues accessing the announcement?

The announcement supplied NIH Office of Extramural Research (OER) webmaster contact information for technical access or linking problems.

What kinds of research settings does the program emphasize?

The description emphasizes research in real-world health care settings and focuses on outcomes, quality, and the practical impact of care decisions.

What is the expected career outcome for awardees?

The program is intended to move researchers from a mentored stage into a stable, self-directed, independent research career, enabling them to lead their own PCOR projects and compete successfully for future funding.

What is the role of interdisciplinary work in this award?

The K99 mentored period is described as a time to expand the applicant's ability to work across disciplines relevant to comparative effectiveness and patient-centered outcomes research.

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