Opportunity Information: Apply for PA 15 159
Apply for PA 15 159
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Impairment of Immune Function, Host Defense and Tissue Homeostasis (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Mar 26, 2015 and posted on Mar 26, 2015.
- Applicants must submit their applications by May 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) County governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Private institutions of higher education Special district governments State governments Independent school districts Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH funding opportunity "Alcohol Impairment of Immune Function, Host Defense and Tissue Homeostasis (R01)" (Funding Opportunity Number PA 15-159) supported investigator-initiated research projects that examine how alcohol consumption alters immune function and related biological processes, with the practical aim of improving health outcomes for people who misuse alcohol. The focus is on understanding the consequences of alcohol exposure on host defense against infections, immune regulation, inflammation, and the maintenance of normal tissue function and repair (tissue homeostasis). In plain terms, the FOA encouraged studies that explain why alcohol use can make people more vulnerable to infections, worsen recovery, or contribute to organ and tissue damage through immune-mediated mechanisms, and it sought knowledge that could be leveraged to prevent or treat these complications.
This was a discretionary grant program using the NIH R01 mechanism, which typically supports well-developed, hypothesis-driven research projects led by a principal investigator and carried out over multiple years. The activity category was health, and the CFDA listing was 93.273 (Alcohol Research Programs). The announcement did not require cost sharing or matching funds, which generally means applicants were not expected to contribute a specific percentage of the project cost from non-federal sources as a condition of the award.
A notable feature of this FOA was its broad invitation to researchers with diverse expertise, reflecting the complexity of alcohol-related immune dysfunction. Projects could reasonably span immunology, infectious disease, inflammation biology, tissue repair and regeneration, systems biology, clinical research, epidemiology, and translational science. The phrase "immune function, host defense and tissue homeostasis" signals interest not only in classic immune endpoints (for example, innate and adaptive immune responses) but also in the downstream consequences for organ integrity and recovery after injury or infection, which can be strongly shaped by immune signaling and inflammatory balance. The overall intent was to generate mechanistic understanding and clinically meaningful insights that could ultimately improve outcomes for patients who abuse alcohol, such as reducing infection risk, improving vaccine or antimicrobial responses, limiting inflammatory tissue injury, or improving healing and recovery trajectories.
Eligibility was intentionally expansive. In addition to typical academic applicants, the FOA allowed applications from small businesses, for-profit organizations (other than small businesses), nonprofit organizations (with or without 501(c)(3) status), public and private institutions of higher education, and a wide range of government entities (state, county, city/township, special district governments, independent school districts, and public housing/Indian housing authorities). It also included Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments), as well as U.S. territories or possessions and regional organizations. The eligibility language explicitly encompassed institutions that serve specific communities, including HBCUs, Hispanic-serving institutions, AANAPISIs, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions. Foreign (non-U.S.) entities were also listed as eligible, which is important for international collaborations or research programs with relevant patient populations and scientific capabilities outside the United States. Faith-based or community-based organizations and eligible federal agencies were also included, underscoring NIH's openness to a variety of institutional homes where strong biomedical research can be conducted.
From an administrative standpoint, the FOA was posted on March 26, 2015, and it remained open through its final closing date of May 7, 2018, with an archive date of June 7, 2018. The sponsoring agency was the National Institutes of Health. Applicants and interested parties were directed to the official NIH program announcement page for full details, and NIH provided contact support through the NIH Office of Extramural Research (OER) web team for issues accessing or linking to the announcement.
In summary, PA 15-159 was an NIH R01 opportunity aimed at advancing rigorous research on how alcohol disrupts immune defenses and tissue stability, and at translating that knowledge into better clinical outcomes for individuals affected by alcohol misuse. It combined a clear scientific emphasis on alcohol-related immune impairment with a wide net for eligible applicants and institutional types, encouraging multidisciplinary approaches to a major public health problem.
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Alcohol Impairment of Immune Function, Host Defense and Tissue Homeostasis (R01)".
What is the Funding Opportunity Number (FON) for this announcement?
The Funding Opportunity Number is PA 15-159.
What kind of grant mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism, which typically supports well-developed, hypothesis-driven research projects led by a principal investigator and carried out over multiple years.
What is the main purpose of this funding opportunity?
The purpose is to support investigator-initiated research that examines how alcohol consumption alters immune function and related biological processes, with the practical aim of improving health outcomes for people who misuse alcohol.
What scientific topics and outcomes are emphasized?
The FOA emphasizes understanding the consequences of alcohol exposure on:
- Host defense against infections
- Immune regulation
- Inflammation
- Tissue homeostasis (maintenance of normal tissue function, repair, and recovery)
In plain language, what kinds of questions was NIH trying to answer?
In plain terms, the FOA encouraged studies that explain why alcohol use can make people more vulnerable to infections, worsen recovery, or contribute to organ and tissue damage through immune-mediated mechanisms. It also sought knowledge that could be leveraged to prevent or treat these complications.
What is meant by "immune function, host defense, and tissue homeostasis" in this FOA?
This phrase signals interest not only in classic immune endpoints (such as innate and adaptive immune responses), but also in downstream consequences for organ integrity and recovery after injury or infection, which can be strongly shaped by immune signaling and inflammatory balance.
Is this opportunity focused on basic research, clinical research, or both?
Based on the description, the FOA broadly invited multidisciplinary projects that could span mechanistic and clinically meaningful work, including areas like clinical research, epidemiology, and translational science, alongside immunology and related biomedical fields.
What research areas or disciplines were encouraged to apply?
The FOA broadly invited researchers with diverse expertise, and projects could reasonably span:
- Immunology
- Infectious disease
- Inflammation biology
- Tissue repair and regeneration
- Systems biology
- Clinical research
- Epidemiology
- Translational science
What kinds of health improvements did this FOA ultimately aim to support?
The overall intent was to generate mechanistic understanding and clinically meaningful insights that could ultimately improve outcomes for patients who abuse alcohol, such as reducing infection risk, improving vaccine or antimicrobial responses, limiting inflammatory tissue injury, or improving healing and recovery trajectories.
What is the activity category for this opportunity?
The activity category listed for this opportunity is Health.
What is the CFDA listing associated with this program?
The CFDA listing is 93.273 (Alcohol Research Programs).
Is this a discretionary grant program?
Yes. The opportunity is described as a discretionary grant program using the NIH R01 mechanism.
Does the FOA require cost sharing or matching funds?
No. The announcement did not require cost sharing or matching funds, meaning applicants were generally not expected to contribute a specific percentage of the project cost from non-federal sources as a condition of the award.
Who was the sponsoring agency?
The sponsoring agency was the National Institutes of Health (NIH).
When was this FOA posted?
The FOA was posted on March 26, 2015.
When did this funding opportunity close?
It remained open through its final closing date of May 7, 2018.
When was the archive date?
The archive date was June 7, 2018.
Is this opportunity still open to applications?
Based on the provided dates (final closing date of May 7, 2018, and archive date of June 7, 2018), this specific FOA is no longer open.
What types of organizations were eligible to apply?
Eligibility was intentionally expansive. Eligible applicants included:
- Small businesses
- For-profit organizations (other than small businesses)
- Nonprofit organizations (with or without 501(c)(3) status)
- Public and private institutions of higher education
- State, county, city/township, and special district governments
- Independent school districts
- Public housing and Indian housing authorities
- Native American tribal governments (federally recognized)
- Tribal organizations (other than federally recognized tribal governments)
- U.S. territories or possessions
- Regional organizations
- Faith-based or community-based organizations
- Eligible federal agencies
Were minority-serving institutions specifically included as eligible?
Yes. The eligibility language explicitly encompassed institutions that serve specific communities, including:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Tribally controlled colleges and universities
- Alaska Native-serving institutions
- Native Hawaiian-serving institutions
Were foreign (non-U.S.) organizations eligible to apply?
Yes. Foreign (non-U.S.) entities were listed as eligible, which can be important for international collaborations or research programs with relevant patient populations and scientific capabilities outside the United States.
Where were applicants directed for official details?
Applicants and interested parties were directed to the official NIH program announcement page for full details.
Who provided contact support for technical issues accessing or linking to the announcement?
NIH provided contact support through the NIH Office of Extramural Research (OER) web team for issues accessing or linking to the announcement.
What makes this FOA "multidisciplinary"?
The FOA explicitly invited diverse expertise because alcohol-related immune dysfunction is complex. It encouraged projects that connect immune changes to real-world outcomes such as infection susceptibility, inflammation-driven tissue injury, and tissue repair or recovery.
What types of alcohol-related health problems were highlighted as relevant?
The description highlights alcohol-related vulnerability to infections, worse recovery trajectories, and organ or tissue damage driven by immune-mediated mechanisms, along with the goal of enabling prevention or treatment of these complications.
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