Opportunity Information: Apply for RFA AA 11 002
Apply for RFA AA 11 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Induced Metabolic and Hepatic Injury (AIMHI) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 2, 2010 and posted on Aug 2, 2010.
- Applicants must submit their applications by Dec 10, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Small businesses Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Independent school districts State governments Native American tribal governments (Federally recognized) Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Alcohol Induced Metabolic and Hepatic Injury (AIMHI) (R01) is a National Institutes of Health funding opportunity issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to push forward research on why and how alcoholic liver disease worsens over time. The central focus is the biological progression from alcohol-induced fatty liver (steatosis) to more advanced, irreversible stages of liver damage, specifically fibrosis and ultimately cirrhosis. The FOA emphasizes the need for innovative, mechanism-driven studies that pinpoint the key cellular and molecular events that drive this progression in real-world clinical contexts, not only in patients with alcoholic liver disease alone, but also in patients whose risk is compounded by common co-existing conditions such as obesity, diabetes, or Hepatitis C infection. In practical terms, NIAAA is looking for research that explains why some individuals with alcohol-related fatty liver move on to severe liver scarring and end-stage disease while others do not, and what biological pathways and triggers account for that increased susceptibility.
A major theme of the announcement is understanding interaction effects and additive risk. Alcohol-related liver injury does not occur in a vacuum, and NIAAA highlights comorbid metabolic disease and viral infection as important accelerants of liver damage. By encouraging studies that examine alcoholic liver disease in combination with obesity and diabetes (which are closely tied to metabolic dysfunction and fatty liver biology) and with Hepatitis C (a well-known driver of chronic liver inflammation and fibrosis), the FOA signals that it wants proposals that can disentangle shared versus distinct mechanisms. The expectation is that clarifying these mechanisms will help the field identify molecular targets that are useful in two ways: first, as potential points for therapeutic intervention (targets that might be blocked or modified to slow or prevent progression), and second, as biomarkers or early detection signals that could help clinicians identify which patients are at highest risk before irreversible liver scarring is established.
This opportunity uses the NIH Research Project Grant (R01) mechanism, meaning it supports hypothesis-driven research projects of the kind typically led by an independent investigator or investigative team, with budgets and timelines consistent with standard R01 awards. NIAAA anticipated committing about $1,500,000 in total funding under this FOA and planned to make up to six awards, with an award ceiling listed at $500,000. As with most NIH announcements, awards were contingent on the availability of funds and on receiving a sufficient number of scientifically strong, meritorious applications.
The administrative details place the opportunity in the health research category under CFDA 93.273 (Alcohol Research Programs). It was posted on August 2, 2010, with an application closing date of December 10, 2010, and an archive date of January 10, 2011. Cost sharing or matching was not required, which aligns with typical NIH research grant structures.
Eligibility for this FOA was broad and included many organization types across the public, private, nonprofit, and governmental spectrum. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and multiple levels of government such as state governments, county governments, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities. It also included a wide range of mission- or community-specific institutions and entities, such as Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and tribal organizations and tribal governments (including both federally recognized and other tribal entities). The FOA also allowed non-U.S. (foreign) entities, regional organizations, U.S. territories or possessions, eligible federal agencies, and faith-based or community-based organizations, reflecting an intent to attract diverse research capabilities and populations.
Overall, the AIMHI (R01) announcement is best understood as a targeted call for mechanistic liver biology research centered on alcohol-related injury, with particular interest in the biological tipping points that move disease from fatty change to scarring and cirrhosis, especially when alcohol use intersects with metabolic disease or Hepatitis C. The anticipated payoff is not just better basic understanding, but clinically meaningful tools and targets that could improve risk prediction, early detection, and eventually prevention of progression to end-stage liver disease in the people most vulnerable to it.
Funding Opportunity Number: RFA-AA-11-002. More information was provided through the NIH Grants Guide link included in the announcement (http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-11-002.html), with NIH Office of Extramural Research (OER) webmaster contacts listed for access or linking issues.
Frequently Asked Questions (FAQs)
What is the Alcohol Induced Metabolic and Hepatic Injury (AIMHI) (R01) funding opportunity?
AIMHI (R01) is an NIH funding opportunity issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It supports research focused on understanding why and how alcoholic liver disease worsens over time, especially the biological progression from alcohol-induced fatty liver (steatosis) to fibrosis and ultimately cirrhosis.
Which NIH institute is offering this opportunity?
The opportunity is offered by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health (NIH).
What is the main scientific focus of this FOA?
The FOA centers on the cellular and molecular mechanisms that drive the transition from alcohol-induced fatty liver to more advanced and irreversible liver damage, particularly fibrosis and cirrhosis, with an emphasis on identifying the key events that cause disease progression.
What stages of liver disease does the FOA emphasize?
The FOA emphasizes the progression from steatosis (fatty liver) to fibrosis (liver scarring) and finally to cirrhosis (end-stage scarring and irreversible liver damage).
What kinds of studies is NIAAA looking to fund?
NIAAA is looking for innovative, mechanism-driven, hypothesis-based studies that pinpoint the critical cellular and molecular events responsible for progression of alcohol-related liver disease, particularly in real-world clinical contexts.
Why does the FOA focus on “real-world clinical contexts”?
Based on the announcement, the intent is to prioritize research that explains disease progression as it occurs in clinically relevant settings, not only in people with alcoholic liver disease alone but also in those whose risk is increased by common co-existing conditions.
Does the FOA only apply to patients with alcoholic liver disease alone?
No. The FOA explicitly highlights interest in patients with alcoholic liver disease both alone and in combination with common co-existing conditions that can compound risk.
Which comorbid conditions are specifically highlighted?
The FOA specifically highlights obesity, diabetes, and Hepatitis C infection as important co-existing conditions that may accelerate alcohol-related liver injury and progression.
What does the FOA mean by interaction effects and additive risk?
The FOA emphasizes that alcohol-related liver injury can be worsened by other conditions (such as metabolic disease or viral infection). It encourages studies that examine how these factors may interact with alcohol-related injury and add to overall risk, including identifying shared versus distinct biological mechanisms.
What key question is NIAAA trying to answer through this program?
A central question is why some people with alcohol-related fatty liver progress to severe scarring and end-stage disease while others do not, and which pathways or triggers explain increased susceptibility.
Are biomarker or early detection goals part of the FOA?
Yes. The FOA points to identifying molecular targets that could serve two purposes: (1) potential therapeutic intervention points to slow or prevent progression, and (2) biomarkers or early detection signals to help identify high-risk patients before irreversible scarring occurs.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is designed to support hypothesis-driven research projects typically led by independent investigators or investigative teams.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AA-11-002.
How much total funding did NIAAA anticipate committing under this FOA?
NIAAA anticipated committing approximately $1,500,000 in total funding under this FOA.
How many awards were planned under this FOA?
The FOA planned to make up to six awards, depending on the availability of funds and the number of scientifically strong, meritorious applications received.
Is there an award ceiling mentioned for this opportunity?
Yes. The award ceiling listed in the announcement is $500,000.
Are awards guaranteed if an application is submitted?
No. The FOA indicates awards are contingent on the availability of funds and on receiving a sufficient number of meritorious applications.
What is the CFDA number and program category for this opportunity?
The opportunity falls under CFDA 93.273, Alcohol Research Programs, in the health research category.
When was this opportunity posted?
The FOA was posted on August 2, 2010.
What was the application closing date?
The application closing date was December 10, 2010.
When was the archive date?
The archive date was January 10, 2011.
Was cost sharing or matching required?
No. The FOA states that cost sharing or matching was not required, consistent with typical NIH research grant structures.
What types of organizations were eligible to apply?
Eligibility was broad and included many organization types across public, private, nonprofit, for-profit, and governmental sectors, as well as certain community- and mission-specific institutions.
Are institutions of higher education eligible?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education were eligible.
Are nonprofit organizations eligible?
Yes. Eligible applicants included nonprofits with 501(c)(3) status and certain nonprofits without 501(c)(3) status.
Are for-profit organizations eligible?
Yes. For-profit organizations were eligible, including small businesses and other for-profit entities.
Which government entities were eligible?
Eligible applicants included state governments, county governments, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities.
Are tribal organizations and tribal governments eligible?
Yes. The FOA included tribal organizations and tribal governments, including federally recognized tribes and other tribal entities.
Are minority-serving institutions included in the eligibility list?
Yes. The eligibility list included Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), and Alaska Native and Native Hawaiian-serving institutions.
Are faith-based or community-based organizations eligible?
Yes. The FOA stated that faith-based and community-based organizations were eligible applicants.
Could non-U.S. (foreign) entities apply?
Yes. The FOA explicitly allowed non-U.S. (foreign) entities, as well as regional organizations.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were included in the eligible applicant categories.
Where can applicants find the official FOA details?
The announcement referenced the NIH Grants Guide FOA page at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-11-002.html
Who was listed for help with access or linking issues?
The announcement noted NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues related to the FOA information.
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