Opportunity Information: Apply for RFA AA 09 007
Apply for RFA AA 09 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alcohol Pharmacotherapy and the Treatment and Prevention of HIV/AIDS (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Feb 12, 2009 and posted on Feb 12, 2009.
- Applicants must submit their applications by Apr 16, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Independent school districts Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education County governments Private institutions of higher education For profit organizations other than small businesses Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Alcohol Pharmacotherapy and the Treatment and Prevention of HIV/AIDS (R01)" (Funding Opportunity Number RFA-AA-09-007) is a discretionary NIH research grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It focuses on the intersection of alcohol use disorders and HIV outcomes, with the central idea that better pharmacologic treatment of alcohol problems can directly improve HIV treatment success and reduce ongoing HIV transmission risk in certain populations. The announcement calls for Research Project Grant (R01) applications that develop and test medication-based approaches for alcohol use disorders specifically in the context of HIV, where alcohol can interfere with treatment adherence, worsen clinical outcomes, and contribute to higher-risk sexual behavior.
The first major scientific aim of the FOA is to support studies that test innovative pharmacotherapies, either as single agents or in combination, for alcohol use disorders among people living with HIV. The expected public health payoff is multi-layered: improved adherence to antiretroviral therapy (ART), fewer treatment complications related to alcohol and antiretroviral interactions, and reduced likelihood of viral mutation that can emerge when ART adherence is inconsistent. In practical terms, the FOA is encouraging projects that treat alcohol use as a key, modifiable driver of HIV-related outcomes, rather than as a separate or secondary issue. It also emphasizes reducing sexual risk-taking, recognizing that alcohol misuse can increase behaviors that facilitate HIV transmission and complicate prevention efforts.
The second major aim shifts toward prevention and asks applicants to evaluate whether medications used to treat alcohol use disorders could help prevent secondary HIV infections in targeted high-risk groups, with specific mention of gay men and minority women. This reflects a prevention framework where reducing hazardous drinking may also reduce exposure opportunities and improve the uptake and consistency of other prevention behaviors. The announcement is not limited to any single medication; instead, it invites "innovative" pharmacologic strategies, which can include evaluating existing AUD medications in HIV-relevant contexts, exploring novel combinations, and designing studies that measure outcomes meaningful to both addiction medicine and HIV prevention/treatment.
In terms of funding structure, this FOA uses the R01 mechanism, meaning it is intended for full-scale research projects with substantial scope and rigor, typically involving well-developed hypotheses, appropriate clinical or community study designs, and robust outcome measurement. It is paired with a parallel funding opportunity of identical scientific scope (RFA-AA-09-008) that uses an expanded R03 mechanism, described as supporting initial safety and feasibility studies of pharmacotherapies for alcohol use disorders in HIV-infected populations. Put simply, the R03 companion is positioned for early-stage, proof-of-concept work, while this R01 announcement is positioned for larger, more definitive projects.
The total estimated funding available under this R01 announcement is $3,000,000, with an anticipated 4 to 6 awards. There is no cost sharing or matching requirement. The activity category is Health, and the CFDA number associated with the program is 93.273 (Alcohol Research Programs). Key dates provided in the source information include a posted and creation date of February 12, 2009, an original and current closing date of April 16, 2009, and an archive date of May 17, 2009, indicating this specific opportunity is from a prior funding cycle but still useful as a model for what NIH sought in this topic area.
Eligibility is broad and includes many types of applicants across the public, private, and nonprofit sectors. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other than small businesses), and multiple levels of government (state, county, city/township, special district, and certain public housing authorities). The eligibility list also explicitly includes tribal governments (federally recognized and other than federally recognized) and tribal organizations, as well as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), U.S. territories or possessions, regional organizations, faith-based or community-based organizations, eligible federal agencies, and non-U.S. entities (foreign organizations). This breadth signals an interest in reaching diverse settings and research teams, including those that can effectively engage priority populations and conduct studies in real-world environments.
Overall, the FOA is essentially a call for rigorous, medication-focused research that treats alcohol use disorders as a pivotal lever for improving HIV treatment outcomes and strengthening HIV prevention. It prioritizes interventions that can demonstrate measurable benefits in ART adherence, virologic outcomes tied to adherence and toxicity concerns, and behavioral risk reduction, while also exploring whether AUD medications can play a meaningful role in reducing onward transmission among groups that face elevated HIV risk. For full details, the announcement points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-09-007.html, and it provides NIH Office of Extramural Research webmaster contacts for access or technical linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Alcohol Pharmacotherapy and the Treatment and Prevention of HIV/AIDS (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-AA-09-007.
Which agency and institute are offering this grant?
This is a discretionary NIH research grant offered by the National Institutes of Health (NIH), through the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What type of grant mechanism does this announcement use?
This funding opportunity uses the NIH Research Project Grant (R01) mechanism.
What is the overall focus of the funding opportunity?
The focus is on developing and testing medication-based (pharmacotherapy) approaches for alcohol use disorders (AUD) specifically in the context of HIV, with the goal of improving HIV treatment outcomes and reducing HIV transmission risk where alcohol misuse contributes to poor outcomes or higher-risk behavior.
Why does the FOA focus on alcohol pharmacotherapy in HIV-related research?
The central idea is that improving pharmacologic treatment of alcohol problems can directly support HIV treatment success and reduce ongoing HIV transmission risk in certain populations, because alcohol can interfere with antiretroviral therapy (ART) adherence, worsen clinical outcomes, and increase higher-risk sexual behavior.
What are the major scientific aims described in the announcement?
The FOA describes two major aims: (1) supporting studies that test innovative pharmacotherapies (single agents or combinations) for alcohol use disorders among people living with HIV, and (2) evaluating whether medications used to treat alcohol use disorders could help prevent secondary HIV infections in targeted high-risk groups.
What kinds of interventions does the FOA encourage?
The FOA encourages innovative pharmacologic strategies for alcohol use disorders. This can include studying single medications or combinations, and evaluating existing AUD medications in HIV-relevant contexts, as well as testing novel combinations, as long as the work is grounded in outcomes meaningful to HIV treatment/prevention and addiction medicine.
Is the opportunity limited to a single medication or a specific drug?
No. The announcement is not limited to any single medication and invites "innovative" pharmacologic strategies.
Who is the primary patient population for the treatment-focused aim?
The treatment-focused aim centers on people living with HIV who also have alcohol use disorders, particularly where alcohol use interferes with HIV treatment adherence and outcomes.
What HIV-related outcomes are highlighted as important in the treatment-focused aim?
The FOA highlights outcomes such as improved adherence to antiretroviral therapy (ART), fewer complications related to alcohol and antiretroviral interactions, and reduced likelihood of viral mutation that can emerge when ART adherence is inconsistent.
Does the FOA address sexual risk behavior and HIV transmission risk?
Yes. The FOA emphasizes reducing sexual risk-taking, noting that alcohol misuse can increase behaviors that facilitate HIV transmission and complicate prevention efforts.
What does the prevention-focused aim cover?
The prevention aim asks applicants to evaluate whether medications used to treat alcohol use disorders could help prevent secondary HIV infections in targeted high-risk groups, based on the idea that reducing hazardous drinking may reduce exposure opportunities and improve other prevention behaviors.
Which high-risk groups are specifically mentioned for the prevention-focused aim?
The FOA specifically mentions gay men and minority women as targeted high-risk groups for the prevention-focused aim.
How does this R01 relate to the companion R03 opportunity?
This R01 FOA is paired with a parallel funding opportunity of identical scientific scope (RFA-AA-09-008) that uses an expanded R03 mechanism. The R03 companion is described as supporting initial safety and feasibility studies in HIV-infected populations, while the R01 is positioned for larger, more definitive projects.
How much total funding is estimated to be available under this R01 announcement?
The total estimated funding available is $3,000,000.
How many awards are anticipated?
The announcement anticipates 4 to 6 awards.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What is the activity category for this opportunity?
The activity category listed is Health.
What CFDA number is associated with this program?
The CFDA number associated with the program is 93.273 (Alcohol Research Programs).
What are the key dates listed for this opportunity?
The source information lists a posted and creation date of February 12, 2009; an original and current closing date of April 16, 2009; and an archive date of May 17, 2009.
Is this opportunity still open?
Based on the listed closing date (April 16, 2009) and archive date (May 17, 2009), this specific opportunity reflects a prior funding cycle rather than a currently open solicitation.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other than small businesses), and multiple levels of government (state, county, city/township, special district, and certain public housing authorities).
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list explicitly includes tribal governments (federally recognized and other than federally recognized) and tribal organizations.
Are minority-serving institutions eligible?
Yes. The eligibility list includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are U.S. territories and regional organizations eligible?
Yes. The eligibility list includes U.S. territories or possessions and regional organizations.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included in the eligibility list.
Are federal agencies eligible applicants?
Yes. The eligibility list includes eligible federal agencies.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list explicitly includes non-U.S. entities (foreign organizations).
Where can applicants find the full funding announcement?
The FOA points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-09-007.html.
Who is listed for technical or linking issues related to accessing the announcement?
The announcement provides NIH Office of Extramural Research webmaster contact information for access or technical linking issues: FBOWebmaster@OD.NIH.GOV.
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