Opportunity Information: Apply for RFA AG 15 001
Apply for RFA AG 15 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alzheimers Disease Core Centers (P30)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jan 16, 2014 and posted on Jan 16, 2014.
- Applicants must submit their applications by May 14, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education County governments Special district governments Independent school districts City or township governments For profit organizations other than small businesses Small businesses State governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession at least five Program Director(s)/Principal Investigator(s) with any PHS agency (or comparable peer reviewed federal, state, or foundation) funded research grants related to AD, neurodegenerative diseases or aging of the nervous system and each with at least two years of support remaining at the time of application or one or more program project grants (P01s) related to AD, neurodegenerative diseases or aging of the nervous system and with at least two years of support remaining at the time of application. Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Alzheimers Disease Core Centers (P30) funding opportunity (RFA-AG-15-001) is a National Institutes of Health (NIH) discretionary grant program in the health and aging research area (CFDA 93.866). It supports the creation or continuation of institutional "core center" infrastructure focused on Alzheimers disease (AD). Rather than funding a single stand-alone research project, this P30 mechanism is intended to build and maintain shared resources, expertise, and coordinated research support that multiple investigators can use to accelerate and strengthen a broad AD research portfolio at an institution.
The overarching purpose of an Alzheimers Disease Core Center (ADCC) is to support and conduct high-quality research on AD and related disorders, with a strong emphasis on enabling and integrating research efforts across investigators and disciplines. These centers are expected to function as shared research resources that make it easier to study AD alongside conditions and processes that can look similar or overlap clinically and biologically, especially normal brain aging and mild cognitive impairment (MCI). A key theme is differentiation: improving the ability of the research community to distinguish AD from typical aging-related changes and from early or ambiguous cognitive syndromes, which is central to earlier and more accurate diagnosis and to targeting prevention and treatment strategies effectively.
The FOA also emphasizes that ADCCs should provide a platform for training and career development, helping to build the next generation of researchers and clinicians working in AD and neurodegenerative disease. In addition, centers are expected to foster the development and dissemination of novel techniques and methodologies. This can include new approaches to measurement, assessment, analytics, biomarkers, imaging, neuropathology, informatics, or other tools that improve the quality, consistency, and impact of AD research. Importantly, the infrastructure supported by the center should help translate research findings into practical advances, including better diagnostic approaches, prevention strategies, and treatments, reflecting NIH's interest in moving discoveries toward real-world clinical benefit.
Eligibility is broad across U.S.-based organizations and includes public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, school districts, special district governments, public housing authorities/Indian housing authorities, and for-profit organizations (including small businesses). The FOA explicitly includes a range of mission-focused institutions and community-serving entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations and regional organizations, provided they meet the program's requirements. Non-U.S. (foreign) institutions and non-U.S. components of U.S. organizations are not eligible to apply; however, "foreign components" as defined by the NIH Grants Policy Statement are allowed, meaning certain international collaborations may be permissible when justified and compliant with NIH policy.
A distinctive requirement for applicant institutions is that they must demonstrate substantial existing strength in AD, neurodegeneration, or aging neuroscience research. Specifically, the institution must have at least five Program Directors/Principal Investigators who each hold peer-reviewed research funding (from any Public Health Service agency or comparable federal, state, or foundation sources) related to AD, neurodegenerative diseases, or aging of the nervous system, and each of those grants must have at least two years of support remaining at the time of application. Alternatively, the institution can qualify by having one or more relevant program project grants (P01s) with at least two years of support remaining. This requirement signals that the ADCC is meant to amplify and coordinate an already robust research base, not to serve as seed funding for institutions without an established funded investigator community.
From a funding perspective, the announcement lists an estimated total funding level of $5,000,000 and an award ceiling of $1,000,000, with no cost sharing or matching requirement. The opportunity was posted January 16, 2014, with an original and current closing date of May 14, 2014, and an archive date of June 14, 2014. The sponsoring agency is the NIH, and the full announcement was available via the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-001.html). For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Taken together, this FOA is best understood as an infrastructure-building and research-enabling program: it supports coordinated, center-based capabilities that help multiple investigators study AD and related disorders more effectively, improve differentiation from normal aging and MCI, train researchers, develop and share methods, and speed translation of scientific findings into improved diagnosis, prevention, and treatment.
Frequently Asked Questions (FAQs): Alzheimers Disease Core Centers (P30) - RFA-AG-15-001
What is the Alzheimers Disease Core Centers (P30) funding opportunity?
This opportunity (RFA-AG-15-001) is a National Institutes of Health (NIH) discretionary grant program (CFDA 93.866) that supports the creation or continuation of institutional Alzheimers Disease Core Centers (ADCCs). It is designed to fund shared, center-based research infrastructure rather than a single stand-alone research project.
What does "P30 core center" mean in practice?
A P30 core center award supports coordinated resources, expertise, and shared services that multiple investigators at an institution can use. The goal is to strengthen and accelerate a broad research portfolio by building and maintaining common infrastructure that enables many related projects to work more effectively and consistently.
What is the main purpose of an Alzheimers Disease Core Center (ADCC)?
The overarching purpose is to support and conduct high-quality research on Alzheimers disease (AD) and related disorders by enabling and integrating research efforts across investigators and disciplines. ADCCs are expected to function as shared research resources that make it easier to coordinate and elevate AD research institution-wide.
Is this grant intended to fund a single research study or project?
No. The FOA emphasizes that the P30 mechanism is not meant to support one stand-alone research project. Instead, it supports institutional core center infrastructure that multiple investigators can access to accelerate and strengthen a broad AD research portfolio.
What research areas are emphasized by this FOA?
The FOA is focused on Alzheimers disease and related disorders, with specific attention to how AD can overlap clinically and biologically with normal brain aging and mild cognitive impairment (MCI). A central theme is improving differentiation between AD, typical aging-related changes, and early or ambiguous cognitive syndromes.
Why does the FOA emphasize distinguishing AD from normal aging and MCI?
Differentiation is described as central to earlier and more accurate diagnosis and to effectively targeting prevention and treatment strategies. The centers are expected to support research that improves the ability to distinguish AD from typical aging-related changes and from MCI.
What kinds of shared resources or capabilities is an ADCC expected to support?
The FOA describes shared infrastructure that can include coordinated research support and resources across investigators and disciplines. It also highlights development and dissemination of novel techniques and methodologies, which can include measurement, assessment, analytics, biomarkers, imaging, neuropathology, informatics, and other tools that improve research quality, consistency, and impact.
Does the FOA include training and career development expectations?
Yes. The FOA emphasizes that ADCCs should provide a platform for training and career development to help build the next generation of researchers and clinicians working in AD and neurodegenerative disease.
How does the FOA describe translation to real-world clinical benefit?
The announcement notes that center infrastructure should help translate research findings into practical advances, including improved diagnostic approaches, prevention strategies, and treatments. This reflects NIH interest in moving discoveries toward real-world clinical benefit.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations. The FOA includes public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), state and local governments, tribal governments and tribal organizations, school districts, special district governments, public housing authorities/Indian housing authorities, and for-profit organizations (including small businesses).
Are mission-focused and community-serving institutions included in the eligibility list?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations and regional organizations, as long as they meet program requirements.
Are non-U.S. (foreign) institutions eligible to apply?
No. Non-U.S. (foreign) institutions and non-U.S. components of U.S. organizations are not eligible to apply under this FOA.
Are any international activities allowed under this FOA?
Yes, the FOA states that "foreign components" (as defined by the NIH Grants Policy Statement) are allowed. This indicates that certain international collaborations may be permissible when justified and compliant with NIH policy, even though foreign institutions themselves are not eligible applicants.
What specific institutional research strength is required to apply?
The applicant institution must demonstrate substantial existing strength in AD, neurodegeneration, or aging neuroscience research. The FOA specifies that the institution must have at least five Program Directors/Principal Investigators who each hold peer-reviewed research funding related to AD, neurodegenerative diseases, or aging of the nervous system, and each of those grants must have at least two years of support remaining at the time of application.
Is there an alternative way to meet the institutional eligibility requirement?
Yes. Alternatively, the institution can qualify by having one or more relevant program project grants (P01s) with at least two years of support remaining.
What does the FOA imply about institutions that do not already have a strong funded research base?
The stated requirement signals that the ADCC mechanism is intended to amplify and coordinate an already robust research base, rather than serve as seed funding for institutions without an established funded investigator community in AD, neurodegeneration, or aging neuroscience.
What is the estimated total funding level for this opportunity?
The announcement lists an estimated total funding level of $5,000,000.
What is the maximum award amount (award ceiling)?
The award ceiling is listed as $1,000,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was this opportunity posted, and what were the key dates?
The opportunity was posted on January 16, 2014. The original and current closing date was May 14, 2014, and the archive date was June 14, 2014.
Which federal agency sponsors this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Where can applicants find the full announcement?
The full announcement was available through the NIH grants guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-15-001.html
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
How should this FOA be understood at a high level?
This FOA is best understood as an infrastructure-building and research-enabling program. It supports coordinated, center-based capabilities that help multiple investigators study AD and related disorders more effectively, improve differentiation from normal aging and MCI, provide training and career development, develop and share methods, and speed translation of findings into improved diagnosis, prevention, and treatment.
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