Opportunity Information: Apply for PAR 14 089
Apply for PAR 14 089
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alzheimers Disease Pilot Clinical Trials (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Feb 5, 2014 and posted on Feb 5, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments County governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses City or township governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Alzheimers Disease Pilot Clinical Trials (R01) funding opportunity (PAR-14-089) is a discretionary grant program from the National Institutes of Health (NIH) focused on moving promising Alzheimers disease (AD) interventions into early-stage human testing. Its central aim is to support Phase I and Phase II clinical trials that evaluate both pharmacological approaches (such as drugs or biologics) and non-pharmacological approaches (such as behavioral, cognitive, lifestyle, device-based, or care-related interventions). The program is designed to cover the full AD spectrum, meaning studies may involve individuals who are pre-symptomatic or at very early risk stages, as well as participants with more advanced or severe disease. In addition to testing interventions, the initiative explicitly encourages research that improves how AD trials are designed and conducted, including work on trial methodology, outcomes, recruitment and retention strategies, and other innovations that make clinical trials more efficient, informative, and feasible.
From an administrative standpoint, this opportunity uses the NIH R01 research project grant mechanism, which generally supports well-defined clinical research projects led by investigators or project teams. The activity category is Health, and it is associated with CFDA number 93.866 (Aging Research). There is no cost sharing or matching requirement, meaning applicants are not required to provide additional funds to match the award. The opportunity was posted on February 5, 2014, and the closing date for applications was May 7, 2017, with an archive date of June 7, 2017, indicating it is no longer open but remains available as a reference for the program goals, scope, and eligibility framework.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include nonprofit organizations (both with and without 501(c)(3) status), public and private institutions of higher education, small businesses, other for-profit organizations (excluding small businesses where specified separately), and multiple levels of government such as state, county, city/township, special district governments, and independent school districts. The opportunity also allows participation by public housing authorities and Indian housing authorities, as well as Native American tribal organizations, including federally recognized tribal governments and other tribal entities. NIH also lists a wide range of mission- or population-focused institutional categories as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations are also eligible, as are eligible agencies of the federal government and regional organizations. Importantly, foreign organizations and foreign institutions are eligible to apply, and non-U.S. components of U.S. organizations may participate; foreign components are allowed consistent with NIH policy.
The sponsor agency is NIH, and the announcement emphasizes clinical testing and methodological advancement in AD trials as the key priorities. For applicants or researchers seeking the full archived announcement details, NIH provided an additional information link hosted on the NIH grants site. NIH also listed contact support through the NIH Office of Extramural Research (OER) webmaster for access or technical issues related to the funding announcement.
Frequently Asked Questions (FAQs): Alzheimers Disease Pilot Clinical Trials (R01) - PAR-14-089
1) What is the Alzheimers Disease Pilot Clinical Trials (R01) opportunity (PAR-14-089)?
PAR-14-089 is an NIH discretionary grant funding opportunity designed to move promising Alzheimers disease (AD) interventions into early-stage testing in humans. It supports clinical research projects using the NIH R01 mechanism, with an emphasis on Phase I and Phase II clinical trials in AD.
2) Who is the sponsor of this funding opportunity?
The sponsor agency is the National Institutes of Health (NIH).
3) What is the main goal of this program?
The central goal is to support early-stage (Phase I and Phase II) clinical trials that evaluate Alzheimers disease interventions and to encourage improvements in how AD trials are designed and conducted.
4) What types of clinical trials does this program support?
The opportunity is focused on Phase I and Phase II clinical trials.
5) What kinds of interventions are eligible under this opportunity?
The announcement supports both pharmacological and non-pharmacological approaches, including:
- Pharmacological approaches (for example, drugs or biologics)
- Non-pharmacological approaches (for example, behavioral, cognitive, lifestyle, device-based, or care-related interventions)
6) Does the program only support drug trials?
No. While pharmacological interventions (such as drugs and biologics) are included, the program also explicitly supports non-pharmacological interventions such as behavioral, cognitive, lifestyle, device-based, and care-related approaches.
7) Which stages of Alzheimers disease can be studied?
The program is designed to cover the full AD spectrum. Studies may involve people who are pre-symptomatic or at very early risk stages, as well as participants with more advanced or severe disease.
8) Is this opportunity only about testing interventions, or can it also support trial design improvements?
It includes both. In addition to intervention testing, the initiative explicitly encourages research that improves AD clinical trials, including innovations in trial methodology, outcomes, recruitment and retention, and other approaches that make trials more efficient, informative, and feasible.
9) What kinds of clinical trial methodology improvements are encouraged?
Based on the announcement summary, encouraged areas include improvements to:
- Trial methodology
- Outcome measures
- Recruitment strategies
- Retention strategies
- Other innovations that improve trial efficiency, feasibility, and informativeness
10) What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 research project grant mechanism, which typically supports well-defined clinical research projects led by an investigator or project team.
11) What is the activity category for this opportunity?
The activity category is Health.
12) What is the CFDA number associated with this program?
The opportunity is associated with CFDA 93.866 (Aging Research).
13) Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to provide additional matching funds as a condition of award.
14) When was this opportunity posted?
It was posted on February 5, 2014.
15) What was the application closing date?
The closing date for applications was May 7, 2017.
16) Is this funding opportunity still open?
No. The archive date is June 7, 2017, indicating the announcement is no longer open for applications and is available as an archived reference.
17) Why is the opportunity still relevant if it is archived?
Even though it is no longer open, it remains available as a reference for understanding the program goals, scope, and eligibility framework described in the announcement.
18) Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. organization types, including nonprofits, universities, businesses, and multiple government entities.
19) Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofit organizations with 501(c)(3) status and nonprofit organizations without 501(c)(3) status.
20) Are colleges and universities eligible?
Yes. Both public and private institutions of higher education are eligible.
21) Are small businesses eligible?
Yes. Small businesses are listed among eligible applicants.
22) Are other for-profit organizations eligible?
Yes. Other for-profit organizations are listed as eligible (with small businesses also separately identified as eligible).
23) Are state and local governments eligible to apply?
Yes. Eligible government applicants include state governments and multiple local government types, including county governments, city or township governments, special district governments, and independent school districts.
24) Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible.
25) Are Native American tribal governments and tribal organizations eligible?
Yes. The eligibility list includes federally recognized Native American tribal governments and other Native American tribal organizations.
26) Are mission- or population-focused institutions (such as HBCUs and HSIs) eligible?
Yes. The eligibility list explicitly includes categories such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
27) Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are listed as eligible.
28) Are federal government agencies eligible?
Yes. Eligible agencies of the federal government are included in the eligibility list.
29) Are regional organizations eligible?
Yes. Regional organizations are listed as eligible.
30) Are foreign (non-U.S.) organizations eligible to apply?
Yes. The opportunity states that foreign organizations and foreign institutions are eligible to apply, consistent with NIH policy.
31) Can non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations may participate, and foreign components are allowed consistent with NIH policy.
32) Where can applicants find the full archived announcement details?
NIH provided an additional information link hosted on the NIH grants site for the full archived announcement details.
33) Who should be contacted for technical issues accessing the announcement?
NIH listed contact support through the NIH Office of Extramural Research (OER) webmaster for access or technical issues related to the funding announcement.
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