Opportunity Information: Apply for RFA AG 16 002
Apply for RFA AG 16 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Alzheimers Disease Sequencing Project (ADSP) Replication Phase Analysis Studies (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Nov 25, 2014 and posted on Nov 25, 2014.
- Applicants must submit their applications by Jun 3, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,250,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,300,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments State governments Native American tribal governments (Federally recognized) Private institutions of higher education County governments Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Alzheimers Disease Sequencing Project (ADSP) Replication Phase Analysis Studies (U01) funding opportunity (RFA-AG-16-002) was a National Institutes of Health (NIH) discretionary grant program that supported work aimed at confirming and extending genetic findings related to Alzheimer's disease. The core purpose of the announcement was to fund targeted sequencing, genotyping, and downstream data analysis efforts specifically tied to the Replication Phase of the ADSP. In practical terms, this meant applicants were expected to take promising genetic signals identified earlier in ADSP discovery efforts and evaluate them in additional samples or datasets, using focused sequencing approaches and high-throughput genotyping to validate associations and strengthen the evidence base for Alzheimer-related risk variants.
The award mechanism was a Cooperative Agreement (U01), which typically indicates an active partnership between NIH program staff and the funded research teams. Rather than operating entirely independently, awardees generally coordinate closely with NIH and other ADSP components to ensure harmonized methods, consistent quality control, and timely data sharing. The activity area fell under health research, with the CFDA listing 93.866 (Aging Research), reflecting the program's placement within the NIH aging and Alzheimer's research portfolio.
Financially, the opportunity listed an estimated total funding amount of $2,250,000, with an award ceiling of $1,300,000. There was no cost sharing or matching requirement, meaning applicants were not required to contribute institutional funds as a condition of the award. The FOA was posted on November 25, 2014, and was open through a single application window with an original and current closing date of June 3, 2015. The opportunity was later archived on July 4, 2015, indicating it is no longer open for submission but remains accessible for reference.
Eligibility was broad and included a wide range of organization types across the public, private, academic, nonprofit, and governmental sectors. Eligible applicants included for-profit organizations (other than small businesses) and small businesses, nonprofits with and without 501(c)(3) status, public and private institutions of higher education, and multiple levels of government such as state, county, city or township, special district governments, and public housing authorities. The eligibility list also explicitly included tribal governments (both federally recognized and other than federally recognized) and tribally controlled colleges and universities. In addition, the FOA highlighted inclusion of institutions and organizations serving specific communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations where appropriate to the research context.
A notable feature of this announcement was its openness to international participation. Non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations were also eligible, and foreign components were allowed as defined by the NIH Grants Policy Statement. This structure supported global collaboration, which can be important for replication studies that benefit from diverse cohorts, larger sample sizes, and different population backgrounds when assessing genetic risk signals.
From an operational standpoint, the announcement directed applicants and interested parties to the full FOA text hosted on the NIH grants website. For technical issues accessing or linking to the announcement, the contact listed was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV). Overall, the opportunity was designed to strengthen the reliability and generalizability of Alzheimer's genetic discoveries by funding the replication-focused sequencing, genotyping, and analytical work needed to confirm candidate variants and support subsequent biological interpretation and translational research.
FAQs: Alzheimer's Disease Sequencing Project (ADSP) Replication Phase Analysis Studies (U01) - RFA-AG-16-002
What is this funding opportunity?
This opportunity was the Alzheimer's Disease Sequencing Project (ADSP) Replication Phase Analysis Studies (U01) funding opportunity announcement (FOA), RFA-AG-16-002. It was an NIH discretionary grant program focused on confirming and extending genetic findings related to Alzheimer's disease.
What was the main goal of the ADSP Replication Phase Analysis Studies FOA?
The core purpose was to fund replication-phase work that validates and strengthens genetic associations identified in earlier ADSP discovery efforts. The FOA aimed to support targeted sequencing, genotyping, and downstream data analysis to confirm promising genetic signals in additional samples or datasets.
What types of research activities were expected under this FOA?
Applicants were expected to conduct work tied to the ADSP Replication Phase, including targeted sequencing, high-throughput genotyping, and downstream data analyses. In practical terms, the work centered on evaluating candidate genetic signals in additional cohorts or datasets to validate associations and increase confidence in Alzheimer-related risk variants.
What does it mean that the award mechanism was a U01 Cooperative Agreement?
The U01 mechanism indicates a Cooperative Agreement, which generally involves an active partnership between NIH program staff and funded research teams. Awardees typically coordinate closely with NIH and other ADSP components to support harmonized methods, consistent quality control, and timely data sharing rather than operating entirely independently.
Which NIH activity area and CFDA listing applied to this opportunity?
The activity area was health research. The CFDA listing was 93.866 (Aging Research), aligning the FOA with NIH's aging and Alzheimer's research portfolio.
How much funding was available through this FOA?
The FOA listed an estimated total funding amount of $2,250,000, with an award ceiling of $1,300,000.
Was cost sharing or matching required?
No. The opportunity stated there was no cost sharing or matching requirement, meaning applicants were not required to contribute institutional funds as a condition of the award.
When was the FOA posted, and what were the application deadlines?
The FOA was posted on November 25, 2014. It had a single application window with an original and current closing date of June 3, 2015.
Is this funding opportunity still open?
No. The opportunity was archived on July 4, 2015, which indicates it is no longer open for new submissions and is available for reference only.
Who was eligible to apply?
Eligibility was broad and included many organization types across public, private, academic, nonprofit, and governmental sectors. Eligible applicants included for-profit organizations (other than small businesses) and small businesses; nonprofits with and without 501(c)(3) status; public and private institutions of higher education; and multiple levels of government (state, county, city or township, special district governments, and public housing authorities).
Were tribal entities eligible to apply?
Yes. The eligibility list explicitly included tribal governments (both federally recognized and other than federally recognized) and tribally controlled colleges and universities.
Did the FOA encourage or include organizations serving specific communities (such as MSIs)?
Yes. The eligibility list highlighted inclusion of institutions and organizations serving specific communities, including Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also mentioned faith-based and community-based organizations where appropriate to the research context.
Were non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA allowed international participation. Non-U.S. entities (foreign organizations and foreign institutions) were eligible to apply. Non-U.S. components of U.S. organizations were also eligible, and foreign components were allowed as defined by the NIH Grants Policy Statement.
Why would international participation be useful for replication studies?
The FOA structure supported global collaboration, which can be important for replication work that benefits from diverse cohorts, larger sample sizes, and varied population backgrounds when assessing genetic risk signals related to Alzheimer's disease.
Where were applicants directed to find the full FOA text?
Applicants and interested parties were directed to the full FOA text hosted on the NIH grants website.
Who was the contact for technical issues accessing or linking to the FOA?
For technical issues accessing or linking to the announcement, the listed contact was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What was the overall program rationale for funding replication-phase sequencing and analysis?
The FOA was designed to strengthen the reliability and generalizability of Alzheimer's genetic discoveries by supporting replication-focused sequencing, genotyping, and analytical work to confirm candidate variants and strengthen the evidence base for Alzheimer-related risk variants, supporting subsequent biological interpretation and translational research.
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