Opportunity Information: Apply for PAR 13 382
Apply for PAR 13 382
- The National Institutes of Health in the education environment health sector is offering a public funding opportunity titled "Analysis of Genome Wide Gene Environment (G x E) Interactions (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.172 Human Genome Research 93.233 National Center on Sleep Disorders Research 93.279 Drug Abuse and Addiction Research Programs 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.879 Medical Library Assistance.
- This funding opportunity was created on Dec 11, 2013 and posted on Oct 30, 2013.
- Applicants must submit their applications by Feb 14, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: State governments Small businesses Public housing authorities/Indian housing authorities City or township governments Independent school districts Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity PAR 13 382, titled "Analysis of Genome Wide Gene Environment (G x E) Interactions (R21)," is a discretionary grant program designed to support exploratory research that uses secondary analyses of existing large-scale genomic datasets. The central focus is on detecting and characterizing gene-by-environment interactions using genome-wide data that have already been generated, such as data from genome-wide association studies (GWAS) or other extensive genomic resources. Rather than paying to collect new genome-wide data, this FOA emphasizes extracting additional scientific value from available datasets by applying analytic approaches that can reveal how genetic variation and environmental exposures work together to influence human health outcomes.
The scientific goal is to improve understanding of complex diseases by identifying situations where an environmental exposure changes the effect of a genetic variant (or where genetic background modifies the impact of an exposure). In practical terms, projects supported under this FOA are expected to investigate how combinations of genetic factors and environmental factors contribute to disease development, disease progression, or differences in severity among individuals and populations. The long-term objective is discovery: finding novel genetic susceptibilities that only become apparent under certain environmental conditions, and clarifying the role that exposures such as lifestyle factors, pollutants, diet, medications, stressors, occupational exposures, or other measurable environmental variables may play in complex human conditions when considered alongside genomic variation.
This opportunity uses the NIH R21 mechanism, which is typically intended for early-stage, proof-of-concept, or high-impact exploratory work where the emphasis is on innovative ideas and feasibility rather than large, multi-year definitive trials. The listed award ceiling is $200,000. There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving an award.
Eligibility is broad and includes many categories of applicants across academia, government, nonprofit, and industry. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (including entities other than small businesses, and small businesses are also eligible); and multiple levels of government such as state governments, county governments, city or township governments, special district governments, independent school districts, and public or Indian housing authorities. The FOA also explicitly includes tribal governments and tribal organizations, including federally recognized Native American tribal governments and other tribal entities, as well as tribally controlled colleges and universities.
The FOA also makes clear that a wide range of institution types and community-serving organizations may apply, including historically Black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations. Importantly, non-U.S. entities are eligible: foreign organizations and foreign institutions may apply, non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement. This international eligibility aligns with the nature of genome-wide datasets and the value of leveraging diverse cohorts and exposure contexts to study G x E effects.
Administratively, the opportunity was posted on October 30, 2013, with an original and current closing date of February 14, 2014, and an archive date of March 17, 2014. The sponsoring agency is the National Institutes of Health. The program is tied to multiple CFDA numbers reflecting NIH-wide relevance across environmental health, human genome research, sleep disorders, substance use and addiction, cancer research and prevention, cardiovascular and lung diseases, blood disorders, arthritis and musculoskeletal/skin diseases, and related areas. That range signals that the FOA is intended to be disease-agnostic and exposure-agnostic: any complex human disease area can be responsive if the project meaningfully uses genome-wide data to test or discover gene-environment interactions.
In terms of what a competitive project would look like under this announcement, the intent is that applicants will bring well-justified hypotheses or discovery frameworks, clearly defined environmental measures or exposure constructs, appropriate statistical or computational methods for genome-wide interaction testing, and careful attention to issues that commonly arise in G x E analyses. Those issues typically include power limitations for interaction effects, multiple testing burden across the genome, heterogeneity of exposure measurement across studies, confounding and correlation between genes and environments, population stratification, replication and validation strategies, and responsible handling of controlled-access genomic data. Since the FOA centers on secondary analyses, applicants would also be expected to demonstrate access to the relevant datasets and an analysis plan that is realistic given the structure, consent limitations, and data quality of the existing resources.
For applicants who need the full announcement details, the NIH link provided in the source points to the official FOA page. For technical issues accessing the announcement or linking problems, the listed contact route is the NIH Office of Extramural Research (OER) webmaster email (FBOWebmaster@OD.NIH.GOV).
FAQs: NIH PAR 13-382 - Analysis of Genome Wide Gene Environment (G x E) Interactions (R21)
What is NIH PAR 13-382?
PAR 13-382 is an NIH discretionary grant funding opportunity titled "Analysis of Genome Wide Gene Environment (G x E) Interactions (R21)." It supports exploratory research focused on detecting and characterizing gene-by-environment interactions using genome-wide data that have already been generated.
What kind of research does this opportunity support?
This FOA supports secondary analyses of existing large-scale genomic datasets (for example, GWAS and other extensive genomic resources) to study genome-wide gene-by-environment (G x E) interactions and how genetic variation and environmental exposures jointly influence human health outcomes.
Does this funding opportunity pay to generate new genome-wide data?
No. The emphasis is on extracting additional scientific value from existing genome-wide datasets rather than collecting new genome-wide data.
What is meant by a genome-wide G x E interaction in this FOA?
In this context, a G x E interaction refers to situations where an environmental exposure changes the effect of a genetic variant on an outcome, or where genetic background modifies the impact of an exposure. The goal is to understand how combinations of genetic and environmental factors contribute to disease development, progression, or severity.
What are examples of environmental exposures that may be relevant?
The FOA describes a broad range of measurable environmental variables, including lifestyle factors, pollutants, diet, medications, stressors, occupational exposures, and other environmental measures that can be considered alongside genomic variation.
What is the scientific goal of the program?
The scientific goal is to improve understanding of complex diseases by identifying and characterizing gene-environment interactions, including discovering novel genetic susceptibilities that only become apparent under certain environmental conditions and clarifying how exposures contribute to complex human conditions when evaluated with genomic variation.
What NIH grant mechanism does this opportunity use?
This opportunity uses the NIH R21 mechanism, which is typically intended for early-stage, proof-of-concept, high-impact exploratory work where the emphasis is on innovative ideas and feasibility rather than large, multi-year definitive trials.
What is the award ceiling listed for this FOA?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement under this funding opportunity.
Who is eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (other than institutions of higher education), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government.
Which government entities are eligible?
Eligible government entities include state governments, county governments, city or township governments, special district governments, independent school districts, and public or Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes federally recognized Native American tribal governments, other tribal entities, tribal organizations, and tribally controlled colleges and universities.
Are community-serving institutions and organizations eligible?
Yes. The FOA explicitly includes institution types and community-serving organizations such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and AANAPISIs, as well as faith-based or community-based organizations.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Foreign organizations and foreign institutions may apply. Non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement.
What kinds of datasets are expected to be used?
Projects are expected to use existing large-scale genomic datasets where genome-wide data have already been generated, such as GWAS datasets or other extensive genomic resources, and then apply analytic methods to evaluate gene-environment interactions.
What makes a project competitive under this FOA?
Based on the FOA description, competitive projects are expected to include well-justified hypotheses or discovery frameworks, clearly defined environmental measures or exposure constructs, appropriate statistical or computational methods for genome-wide interaction testing, and a realistic analysis plan aligned with the structure and limitations of the existing datasets.
What analytical challenges does the FOA highlight for G x E studies?
The FOA highlights common issues in G x E analyses, including limited power for interaction effects, multiple testing burden across the genome, heterogeneity in exposure measurement across studies, confounding and correlation between genes and environments, population stratification, replication and validation strategies, and responsible handling of controlled-access genomic data.
Do applicants need to show they can access the data they plan to analyze?
Yes. Since the FOA is centered on secondary analyses, applicants are expected to demonstrate access to relevant datasets and to propose an analysis plan that is realistic given dataset structure, consent limitations, and data quality.
Is this FOA limited to a specific disease area?
No. The FOA is described as disease-agnostic and exposure-agnostic, meaning any complex human disease area can be responsive if the project meaningfully uses genome-wide data to test or discover gene-environment interactions.
Which agency sponsors this funding opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
When was this opportunity posted and when did it close?
The opportunity was posted on October 30, 2013. The original and current closing date listed is February 14, 2014. The archive date is March 17, 2014.
What do the multiple CFDA numbers indicate?
The multiple CFDA numbers reflect NIH-wide relevance across many health and research areas (for example environmental health, human genome research, sleep disorders, substance use and addiction, cancer, cardiovascular and lung diseases, blood disorders, arthritis and musculoskeletal/skin diseases, and related areas), reinforcing that the FOA is broadly applicable to complex human conditions.
Where can applicants find the full official announcement?
The source notes that the NIH link provided points to the official FOA page for full announcement details.
Who should be contacted for technical issues accessing the announcement link?
For technical issues accessing the announcement or linking problems, the listed contact route is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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| Funding Opportunity |
|---|
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 14 001 Funding Number: RFA ES 14 001 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Senior Fellowship (Parent F33) Apply for PA 14 151 Funding Number: PA 14 151 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Administrative Supplements for the U.S. Japan Brain Research Cooperative Program (BRCP) U.S. Entity (Administrative Supplement) Apply for PA 14 249 Funding Number: PA 14 249 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $50,000 |
| Superfund Hazardous Substance Research and Training Program (P42) Apply for RFA ES 14 007 Funding Number: RFA ES 14 007 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Interventions for Health Promotion and Disease Prevention in Native American Populations (R01) Apply for PAR 14 260 Funding Number: PAR 14 260 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) Research (U01) Apply for RFA TW 14 001 Funding Number: RFA TW 14 001 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $600,000 |
| Hubs of Interdisciplinary Research and Training in Global Environmental and Occupational Health (GEOHealth) Research Training (U2R) Apply for RFA TW 14 002 Funding Number: RFA TW 14 002 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $300,000 |
| Spatial Uncertainty Data, Modeling, and Communication (R21) Apply for PA 15 009 Funding Number: PA 15 009 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $275,000 |
| Spatial Uncertainty Data, Modeling, and Communication (R01) Apply for PA 15 010 Funding Number: PA 15 010 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Spatial Uncertainty Data, Modeling, and Communication (R03) Apply for PA 15 011 Funding Number: PA 15 011 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $50,000 |
| Environmental Influences during Windows of Susceptibility in Breast Cancer Risk (U01) Apply for RFA ES 14 012 Funding Number: RFA ES 14 012 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $600,000 |
| Coordinating Center for the Breast Cancer and the Environment Research Program (U01) Apply for RFA ES 14 011 Funding Number: RFA ES 14 011 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $600,000 |
| NLM Administrative Supplements for Informationist Services in NIH funded Research Projects (Admin Supp) Apply for PA 15 249 Funding Number: PA 15 249 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $25,000 |
| Superfund Research Program Occupational and Safety Education Programs on Emerging Technologies (R25) Apply for RFA ES 15 014 Funding Number: RFA ES 15 014 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Direct Phase II SBIR Grants to Support Extended Development, Hardening, and Dissemination of Technologies in Biomedical Computing, Informatics, and Big Data Science (R44) Apply for PAR 15 288 Funding Number: PAR 15 288 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R01) Apply for PAR 15 308 Funding Number: PAR 15 308 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Translational Studies on Adducts for Cancer Risk Identification and Prevention (U01) Apply for PAR 15 307 Funding Number: PAR 15 307 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: Case Dependent |
| Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R21) Apply for PAR 15 309 Funding Number: PAR 15 309 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
| Superfund Basic Research and Training Program (P42) Apply for RFA ES 08 005 Funding Number: RFA ES 08 005 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $1,800,000 |
| Exploratory Innovations in Biomedical Computational Science and Technology (R21) Apply for PAR 06 411 Funding Number: PAR 06 411 Agency: National Institutes of Health Category: Education Environment Health Funding Amount: $200,000 |
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