Opportunity Information: Apply for PAR 10 238
Apply for PAR 10 238
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Ancillary Studies to the ACCORD Clinical Trial or the ACCORD Follow on Study (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jul 27, 2010 and posted on Jul 27, 2010.
- Applicants must submit their applications by Sep 28, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education County governments Independent school districts Private institutions of higher education City or township governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity titled "Ancillary Studies to the ACCORD Clinical Trial or the ACCORD Follow on Study (R01)" (Funding Opportunity Number PAR 10-238) is a National Institutes of Health (NIH) funding announcement designed to support additional, focused research that builds directly on the ACCORD program. ACCORD, short for Action to Control Cardiovascular Disease, was a major clinical trial effort, and this announcement is aimed at getting more scientific value out of that investment by encouraging investigators to ask new questions using existing ACCORD resources or by gathering new follow-up information from ACCORD participants.
The main purpose of the opportunity is to fund ancillary studies that do one of two things. First, applicants can propose research that uses stored biospecimens from ACCORD participants to explore biological mechanisms related to outcomes or other clinical measures. In practical terms, this means studies that take advantage of banked samples (for example, blood or other collected materials) to evaluate biomarkers, pathways, genetic or metabolic signals, or other lab-based measures that may help explain why certain clinical outcomes occurred. Second, applicants can propose studies that collect new observational data as part of the ACCORD follow-on study. This track is focused on gathering additional non-interventional information after the original trial, such as longer-term health outcomes, new clinical measurements, updated risk factor profiles, or other follow-up data that could deepen understanding of cardiovascular disease and related conditions in the ACCORD cohort.
This funding announcement uses the NIH Research Project Grant mechanism (R01), which is the standard investigator-initiated research grant for a defined project with specific aims. Because proposed projects could range widely in scientific scope, methods, and intensity, NIH does not set a single fixed award size or project length for all applicants. Instead, both the budget and duration are expected to vary depending on what each study proposes and what is justified to complete the work. Likewise, NIH does not commit to a specific number of awards in advance; the total number of funded projects and the total dollars awarded depend on the volume of applications, their scientific quality, their proposed timelines, and their requested costs.
The opportunity was issued by NIH, with leadership from the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The associated health-related activity areas and CFDA program numbers include sleep disorders research (93.233) and several cardiovascular, lung, blood, and related research areas (93.837, 93.838, 93.839). There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.
Eligibility is broad and includes many types of organizations that commonly apply for NIH research grants. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other than small businesses), and multiple levels of government (state, county, city/township, special district governments, and independent school districts). The announcement also allows a wide range of other applicants, such as federally recognized tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a variety of specialized institution types including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. It also notes that non-U.S. entities (foreign organizations), U.S. territories or possessions, regional organizations, and eligible federal agencies may apply, reflecting NIH's inclusive approach to who can propose scientifically meritorious work.
In terms of timing, the announcement was posted on July 27, 2010, and the original and final closing date listed is September 28, 2012, with an archive date of October 29, 2012. The full official announcement and requirements were provided through the NIH grants policy and guidance system, with an additional information link directing applicants to the NIH guide page for PAR 10-238. For technical issues accessing the announcement online, the contact listed is the NIH Office of Extramural Research (OER) webmaster.
Overall, this FOA is best understood as an NIH effort to encourage high-value add-on research tied to ACCORD, either by leveraging the unique stored biospecimen collection to answer mechanistic questions or by extending knowledge through new observational follow-up in the ACCORD cohort, using the flexible and widely used R01 mechanism to support a range of scientifically driven projects.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Ancillary Studies to the ACCORD Clinical Trial or the ACCORD Follow on Study (R01)."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR 10-238.
Who is the funder for this opportunity?
This is a National Institutes of Health (NIH) funding announcement.
Which NIH institutes lead this funding announcement?
The announcement is led by the National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What is the ACCORD program referenced in the announcement?
ACCORD stands for Action to Control Cardiovascular Disease and is described as a major clinical trial effort. This announcement is intended to build directly on ACCORD to generate additional scientific value from that investment.
What is the overall purpose of this funding opportunity?
The purpose is to support additional, focused research (ancillary studies) that builds directly on the ACCORD clinical trial or the ACCORD follow-on study, either by using existing ACCORD resources or by collecting new follow-up observational information from ACCORD participants.
What types of projects are encouraged under this FOA?
The FOA encourages ancillary studies that do one of two things: (1) use stored biospecimens from ACCORD participants to explore biological mechanisms related to outcomes or other clinical measures, or (2) collect new observational (non-interventional) data as part of the ACCORD follow-on study.
Can a project use stored biospecimens from ACCORD participants?
Yes. One main focus area is research using stored biospecimens from ACCORD participants to investigate biological mechanisms tied to outcomes or other clinical measures.
What kinds of questions can biospecimen-based ancillary studies address?
Based on the announcement, biospecimen studies can evaluate biomarkers, biological pathways, genetic signals, metabolic signals, or other laboratory measures that may help explain why certain clinical outcomes occurred in the ACCORD cohort.
Does the FOA support collecting new data from participants after the original trial?
Yes. The second main track supports collection of new observational data in the ACCORD follow-on study to deepen understanding of longer-term outcomes and related factors within the ACCORD cohort.
What does "observational (non-interventional) follow-up data" mean in this FOA?
It refers to gathering additional information after the original clinical trial without introducing a new intervention. Examples described include longer-term health outcomes, new clinical measurements, updated risk factor profiles, and other follow-up data.
What grant mechanism is used for this opportunity?
This FOA uses the NIH Research Project Grant mechanism (R01).
Is this an investigator-initiated research grant?
Yes. The R01 is described as the standard investigator-initiated research grant for a defined project with specific aims.
Is there a fixed award amount for all applicants?
No. NIH does not set a single fixed award size for all applicants under this FOA. Budgets are expected to vary depending on what each study proposes and what is justified to complete the work.
Is there a fixed project period/length for all awards?
No. NIH does not set a single fixed duration for all projects under this FOA. The project length is expected to vary based on the proposed work and justification.
How many awards will NIH make under this opportunity?
NIH does not commit to a specific number of awards in advance. The number of funded projects and total dollars awarded depend on application volume, scientific quality, proposed timelines, and requested costs.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Which CFDA program numbers are associated with this opportunity?
The activity areas and CFDA program numbers listed include sleep disorders research (93.233) and cardiovascular, lung, blood, and related research areas (93.837, 93.838, 93.839).
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other than small businesses); and government entities such as state, county, city/township, special district governments, and independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized tribal governments and tribal organizations are listed as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are minority-serving institutions specifically included as eligible applicants?
Yes. The FOA lists multiple types of specialized institutions as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among eligible applicants.
Can non-U.S. (foreign) organizations apply?
Yes. The announcement notes that non-U.S. entities (foreign organizations) may apply.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are included in the list of eligible applicants.
Are regional organizations eligible?
Yes. Regional organizations are listed as eligible applicants.
Are federal agencies eligible to apply?
Yes. The announcement states that eligible federal agencies may apply.
When was this funding opportunity posted?
The announcement was posted on July 27, 2010.
What were the closing dates for this opportunity?
The original and final closing date listed is September 28, 2012.
When was the opportunity archived?
The archive date is October 29, 2012.
Where can applicants find the official announcement and requirements?
The full official announcement and requirements were provided through the NIH grants policy and guidance system, with an additional information link directing applicants to the NIH guide page for PAR 10-238.
Who is the technical contact for problems accessing the announcement online?
For technical issues accessing the announcement online, the contact listed is the NIH Office of Extramural Research (OER) webmaster.
What is the main rationale for supporting ACCORD ancillary studies?
The FOA is positioned as a way to get more scientific value out of the ACCORD investment by encouraging new questions that can be answered using existing ACCORD resources (such as stored biospecimens) or by gathering new observational follow-up information from ACCORD participants.
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