Opportunity Information: Apply for RFA AA 12 011
Apply for RFA AA 12 011
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Announcement of a Limited Competition for the Continuation of the Cooperative Agreement on the Interaction of HIV Infection and Alcohol Abuse on Central Nervous System Morbidity (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Jan 18, 2012 and posted on Jan 18, 2012.
- Applicants must submit their applications by Apr 16, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,210,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $810,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
This funding opportunity, RFA-AA-12-011, is a National Institutes of Health (NIH) announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) for a limited competition to continue an existing cooperative agreement (U01) focused on how HIV infection and alcohol abuse together affect the central nervous system. It is specifically framed as a competing renewal, meaning it is intended to support the continuation of an established line of work rather than launching a broad, open call for brand-new projects. The overall purpose is to evaluate the cumulative and progressive effects on the brain that occur when chronic heavy alcohol use and HIV infection co-occur, using advanced in vivo magnetic resonance imaging (MRI) approaches.
The scientific emphasis is on investigating both the separate effects of HIV and alcohol and the ways they interact to influence neurocognitive performance and the brain's structural and functional integrity. In practical terms, the supported work is expected to link sophisticated MRI-based measures of brain structure and function with real-world outcomes such as cognitive and motor decline, and to clarify how these outcomes may worsen with continued heavy drinking or potentially improve with sustained abstinence from alcohol. A major long-term objective is to identify in vivo markers of neuropathology that help explain why some individuals with HIV who drink heavily experience more pronounced neurological problems, and how those brain and behavioral changes relate to HIV disease status over time.
Because the award mechanism is a cooperative agreement, the project is meant to be conducted in close collaboration with NIAAA rather than operating as a fully independent research grant. Over a five-year project period, the investigator is expected to work interactively with the institute, reflecting the "substantial NIH involvement" typical of U01 awards. The program is positioned within NIH's health research mission, with the relevant CFDA listing being 93.273 (Alcohol Research Programs).
The announcement anticipates making a single award. The estimated total funding amount listed is $1,210,000, and the award ceiling is $810,000. There is no cost sharing or matching requirement, so applicants are not required to provide additional non-federal funds as a condition of the award. The opportunity was posted on January 18, 2012, with an application due date (original and current closing date) of April 16, 2012, and an archive date of May 17, 2012.
Eligibility is restricted and does not include foreign institutions or foreign components. Non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components as defined by the NIH Grants Policy Statement are not allowed. The listing indicates "Others" as eligible applicants, with additional details referenced in the full announcement, which is typical of limited competitions where only certain organizations (often those tied to the existing cooperative agreement) are permitted to submit.
For applicants or interested parties, the full announcement is linked through the NIH Grants Guide (http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-12-011.html). Technical assistance for accessing or linking to the announcement is directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the funding opportunity number and who is sponsoring it?
The opportunity is RFA-AA-12-011. It is a National Institutes of Health (NIH) announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What type of funding mechanism is being used?
This opportunity uses a cooperative agreement mechanism: U01.
What does "cooperative agreement (U01)" mean for how the project will be run?
A U01 indicates substantial NIH involvement. The project is expected to be conducted in close collaboration with NIAAA rather than operating as a fully independent research grant, with interactive work with the institute across the project period.
Is this an open competition for new projects?
No. This is a limited competition framed as a competing renewal to continue an existing cooperative agreement. It is intended to support continuation of an established line of work rather than a broad call for entirely new projects.
What is the main scientific purpose of this opportunity?
The purpose is to evaluate the cumulative and progressive effects on the brain when chronic heavy alcohol use and HIV infection co-occur, using advanced in vivo magnetic resonance imaging (MRI) approaches.
What topics or relationships is the research expected to investigate?
The research emphasis includes: (1) the separate effects of HIV and alcohol on the central nervous system, and (2) how HIV and alcohol interact to influence neurocognitive performance and the brain's structural and functional integrity.
What kinds of measures or methods are highlighted?
Advanced in vivo MRI approaches are specifically highlighted, with an expectation to link MRI-based measures of brain structure and function to outcomes such as cognitive and motor decline.
What kinds of outcomes should the supported work connect to brain imaging?
The announcement describes linking sophisticated MRI measures to real-world outcomes including cognitive and motor decline, and examining how outcomes may worsen with continued heavy drinking or potentially improve with sustained abstinence from alcohol.
What long-term objective is described for the program?
A major long-term objective is to identify in vivo markers of neuropathology that help explain why some individuals with HIV who drink heavily experience more pronounced neurological problems, and how brain and behavioral changes relate to HIV disease status over time.
How long is the project period?
The project period is five years.
How many awards does NIH/NIAAA expect to make?
The announcement anticipates making a single award.
What is the estimated total funding amount for this opportunity?
The estimated total funding amount listed is $1,210,000.
What is the award ceiling?
The award ceiling is $810,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, so applicants are not required to provide additional non-federal funds as a condition of the award.
What is the relevant CFDA number for this program?
The relevant CFDA listing is 93.273 (Alcohol Research Programs).
When was the opportunity posted?
The opportunity was posted on January 18, 2012.
What is the application due date?
The application due date (original and current closing date) is April 16, 2012.
When was the opportunity archived?
The archive date is May 17, 2012.
Who is eligible to apply?
Eligibility is restricted. The listing indicates "Others" as eligible applicants, with additional details referenced in the full announcement. This is typical of limited competitions where only certain organizations (often those tied to the existing cooperative agreement) are permitted to submit.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply.
Are non-U.S. entities eligible to apply?
No. Non-U.S. entities are not eligible to apply.
Are foreign components allowed as part of an application?
No. Foreign components as defined by the NIH Grants Policy Statement are not allowed.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
Where can applicants find the full announcement?
The full announcement is available via the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-12-011.html
Who should be contacted for technical assistance accessing or linking to the announcement?
Technical assistance is directed to the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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