Opportunity Information: Apply for RFA HS 10 005
Apply for RFA HS 10 005
- The Agency for Health Care Research and Quality in the health recovery act sector is offering a public funding opportunity titled "ARRA AHRQ Recovery Act 2009 Limited Competition PROSPECT Studies Building New Clinical Infrastructure for Comparative Effectiveness Research (R01)" and is now available to receive applicants.
- This funding opportunity was created on Jan 13, 2010 and posted on Dec 8, 2009.
- Applicants must submit their applications by Feb 17, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $44,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $3,000,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments Private institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Indian/Native American Tribal Governments (Other than Federally Recognized) Units of local government
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Opportunity Summary:
The ARRA AHRQ Recovery Act 2009 Limited Competition PROSPECT Studies opportunity (RFA HS 10-005) was a time-limited Research Project Grant (R01) funding announcement from the Agency for Healthcare Research and Quality (AHRQ), supported by American Recovery and Reinvestment Act of 2009 (ARRA) funds (Public Law 111-5). Its central aim was to strengthen the United States' capacity for comparative effectiveness research (CER) by building and improving clinical data infrastructure that can collect high-quality prospective information from electronic clinical databases. In practical terms, the FOA sought projects that would move beyond simply analyzing existing retrospective records and instead create systems and methods that support ongoing, forward-looking data capture in real-world care settings so that researchers can generate new evidence comparing the benefits and harms of different healthcare interventions.
The program focus was PROSPECT, which stands for Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies. The emphasis was on upgrading the quality, depth, and scale of electronic data collection so it could serve as a reliable foundation for CER across a wide range of interventions, including diagnostics, therapeutics, medical devices, behavioral interventions, and clinical procedures. Applicants were expected to propose infrastructure and methodological improvements that make electronic clinical data more useful for research, such as better ways to capture outcomes over time, enhance data completeness and accuracy, and support consistent, systematic prospective data collection across clinical environments.
A key priority was ensuring that the resulting evidence would be more applicable to patients often missing from or underrepresented in randomized controlled trials and, more broadly, to people who may have limited access to healthcare. The FOA explicitly highlighted populations such as patients with multiple comorbidities, individuals at the extremes of age, and racial and ethnic minorities. By investing in prospective data systems embedded in everyday care, AHRQ aimed to enable CER that reflects the complexity of real patients and real clinical practice, rather than idealized trial conditions. This positioning also implies a focus on pragmatic data capture approaches that can operate at scale and in diverse healthcare settings.
Administratively, this was a discretionary grant opportunity using the grant funding instrument under a health-related ARRA activity category. AHRQ anticipated making about five awards, with an estimated total program funding level of $44,000,000 and an award ceiling of $3,000,000 per project. There was no cost sharing or matching requirement stated. The FOA was posted on December 8, 2009, with key dates reflecting its Recovery Act urgency: an original closing date of January 20, 2010, later extended to a current closing date of February 17, 2010, and an archive date of March 17, 2010.
Eligibility was broad and included state governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized tribal governments. The announcement also indicated additional eligible applicants such as eligible federal government agencies and units of local government, as clarified in the eligibility text. The intent behind this broad eligibility appears aligned with the infrastructure-building nature of the program, where partnerships among academic institutions, healthcare systems, government entities, and tribal organizations can be essential for accessing clinical data sources and implementing prospective data collection in real care delivery contexts.
The full announcement was hosted through the NIH grants guide system (even though AHRQ was the sponsoring agency), with support contacts provided via the NIH Office of Extramural Research (OER) webmaster for technical access or linking issues. Overall, the opportunity can be summarized as an ARRA-funded push to rapidly expand the national capability to conduct robust comparative effectiveness research by creating and refining prospective, patient-level electronic clinical data systems that can produce actionable evidence for a broad range of interventions, especially for populations commonly overlooked by traditional clinical trials.
Frequently Asked Questions (FAQs)
What is the ARRA AHRQ Recovery Act 2009 Limited Competition PROSPECT Studies opportunity (RFA HS 10-005)?
It was a time-limited AHRQ funding opportunity that used American Recovery and Reinvestment Act of 2009 (ARRA) funds (Public Law 111-5) to support Research Project Grants (R01). The program focused on strengthening U.S. comparative effectiveness research (CER) capacity by improving clinical data infrastructure for prospective, high-quality data collection from electronic clinical databases.
Who was the sponsoring agency for this opportunity?
The sponsoring agency was the Agency for Healthcare Research and Quality (AHRQ). The full announcement was hosted through the NIH grants guide system even though AHRQ was the sponsor.
What does PROSPECT stand for?
PROSPECT stands for Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies.
What was the main goal of the program?
The central aim was to build and improve clinical data infrastructure that can collect high-quality prospective information from electronic clinical databases, enabling stronger comparative effectiveness research in real-world care settings.
How is this different from research that analyzes existing clinical records?
The opportunity emphasized moving beyond retrospective analysis of existing records. Applicants were expected to develop systems and methods that support ongoing, forward-looking (prospective) data capture so researchers can generate new evidence over time, embedded in everyday clinical practice.
What types of projects was the FOA looking to fund?
The FOA sought infrastructure and methodological improvements that make electronic clinical data more useful for CER. Examples described include better methods to capture outcomes over time, improvements to data completeness and accuracy, and approaches that enable consistent, systematic prospective data collection across clinical environments.
What kinds of healthcare interventions were intended to be supported by the data infrastructure?
The improved data systems were intended to support CER across a wide range of interventions, including diagnostics, therapeutics, medical devices, behavioral interventions, and clinical procedures.
Why was prospective data collection emphasized?
Because prospective, systematic data capture in real-world care settings can produce evidence that reflects actual clinical practice and real patient complexity, rather than relying only on idealized trial conditions or incomplete retrospective records.
Did the FOA prioritize specific patient populations?
Yes. A key priority was evidence that is applicable to patients often missing from or underrepresented in randomized controlled trials and to people who may have limited access to healthcare.
Which specific populations were highlighted as important to include?
The FOA explicitly highlighted patients with multiple comorbidities, individuals at the extremes of age, and racial and ethnic minorities.
What funding mechanism was used?
The funding instrument was a discretionary grant using the Research Project Grant (R01) mechanism.
How many awards did AHRQ expect to make?
AHRQ anticipated making about five awards.
What was the estimated total program funding level?
The estimated total funding level for the program was $44,000,000.
What was the maximum award size (ceiling) per project?
The award ceiling was $3,000,000 per project.
Was cost sharing or matching required?
No cost sharing or matching requirement was stated.
When was the funding opportunity posted?
The FOA was posted on December 8, 2009.
What were the application due dates?
The original closing date was January 20, 2010, and it was later extended to a current closing date of February 17, 2010.
When was the opportunity archived?
The archive date was March 17, 2010.
What types of organizations were eligible to apply?
Eligibility included state governments; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; and Native American tribal organizations other than federally recognized tribal governments. The announcement also indicated additional eligible applicants such as eligible federal government agencies and units of local government (as clarified in the eligibility text).
Why was eligibility so broad?
Based on the program description, the broad eligibility aligns with the infrastructure-building nature of the initiative, where partnerships among academic institutions, healthcare systems, government entities, and tribal organizations can be important for accessing clinical data sources and implementing prospective data collection within real care delivery settings.
What kind of activity category was associated with this grant?
It was described as a health-related ARRA activity category funded through the American Recovery and Reinvestment Act.
Where could applicants find the full announcement?
The full announcement was hosted through the NIH grants guide system.
Who was listed as the support contact for technical access or linking issues?
Support contacts were provided via the NIH Office of Extramural Research (OER) webmaster for technical access or linking issues.
In one sentence, how can this opportunity be summarized?
It was an ARRA-funded, time-limited AHRQ R01 initiative to rapidly expand national CER capability by creating and refining prospective, patient-level electronic clinical data systems that can generate actionable evidence across many interventions, especially for populations often overlooked by traditional clinical trials.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA HS 10 005) also looked into and applied for these:
| Funding Opportunity |
|---|
| ARRA AHRQ Recovery Act 2009 Limited Competition Electronic Data Methods (EDM) Forum for Comparative Effectiveness Research (U13) Apply for RFA HS 10 006 Funding Number: RFA HS 10 006 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: Case Dependent |
| AHRQ ARRA Recovery Act 2009 Limited Competition AHRQ Mentored Clinical Scientists Comparative Effectiveness Development Award (K12) Apply for RFA HS 10 007 Funding Number: RFA HS 10 007 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $850,000 |
| AHRQ ARRA Recovery Act 2009 Limited Competition AHRQ Institutional National Research Service Award (NRSA) Postdoctoral Comparative Effectiveness Development Training Award (T32) Apply for RFA HS 10 011 Funding Number: RFA HS 10 011 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $900,000 |
| Recovery Act 2009 Limited Competition OS ARRA Comparative Effectiveness Research to Optimize Prevention and Healthcare Management for the Complex Patient (R21) Apply for RFA HS 10 009 Funding Number: RFA HS 10 009 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: Case Dependent |
| American Recovery and Reinvestment Act of 2009, Information Technology Professionals in Health Care Competency Examination for Individuals Apply for FOA OC HIT 10 002 Funding Number: FOA OC HIT 10 002 Agency: Office of the National Coordinator Category: Health Recovery Act Funding Amount: $6,000,000 |
| American Recovery and Reinvestment Act of 2009, Information Technology Professionals in Health Care Training Grants Furnishing Academic Program Development Assistance for University Based Training of Health Information Technology Professionals Apply for FOA OC HIT 10 003 Funding Number: FOA OC HIT 10 003 Agency: Office of the National Coordinator Category: Health Recovery Act Funding Amount: $6,000,000 |
| American Recovery and Reinvestment Act of 2009, Health Information Strategic Health IT Advanced Research Projects Apply for HHS 2010 ONC TR 005 Funding Number: HHS 2010 ONC TR 005 Agency: Office of the National Coordinator Category: Health Recovery Act Funding Amount: $18,000,000 |
| Recovery Act 2009 Limited Competition Expansion of Research Capability to Study Comparative Effectiveness in Complex Patients (R24) Apply for RFA HS 10 001 Funding Number: RFA HS 10 001 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $500,000 |
| ARRAOS Recovery Act Limited Competition Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research Clinical Trials (RC4) Apply for RFA OD 10 001 Funding Number: RFA OD 10 001 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRAOS Recovery Act Limited Competition Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research Pilot Research (RC4) Apply for RFA OD 10 002 Funding Number: RFA OD 10 002 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $500,000 |
| Recovery Act Limited Competition Comparative Effectiveness Research on Upper Endoscopy in Gastroesophageal Reflux Disease, Eradication Methods for Methicillin Resistant Staphylococcus aureus and Dementia Detection and Management Strategies (RC4) Apply for RFA OD 10 008 Funding Number: RFA OD 10 008 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $500,000 |
| Recovery Act Limited Competition NIH Directors Opportunity for Research in Five Thematic Areas (RC4) Apply for RFA OD 10 005 Funding Number: RFA OD 10 005 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| Recovery Act Limited Competition Methodology Development in Comparative Effectiveness Research (RC4) Apply for RFA OD 10 009 Funding Number: RFA OD 10 009 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $500,000 |
| Recovery Act Limited Competition Research On Biosamples From Selected Diabetes Clinical Studies (RC4) Apply for RFA OD 10 010 Funding Number: RFA OD 10 010 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Accelerating Adoption of Comparative Effectiveness Research Results by Providers and Patients (R18) Apply for RFA AE 10 001 Funding Number: RFA AE 10 001 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| Recovery Act Limited Competition Institutional Comparative Effectiveness Research Mentored Career Development Award (KM1) Apply for RFA OD 10 011 Funding Number: RFA OD 10 011 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Limited Competition Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01) Apply for RFA HS 10 020 Funding Number: RFA HS 10 020 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $4,000,000 |
| Recovery Act Limited Competition Framework Programs for Global Health Signature Innovations Initiative (R24) Apply for RFA OD 10 007 Funding Number: RFA OD 10 007 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $250,000 |
| Recovery Act Limited Competition Program to Enhance NIH supported Global Health Research Involving Human Subjects (S07) Apply for RFA OD 10 006 Funding Number: RFA OD 10 006 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $50,000 |
| ARRA OS Recovery Act 2009 Limited Competition Accelerating Implementation of Comparative Effectiveness Findings on Clinical and Delivery System Interventions by Leveraging AHRQ Networks (R18) Apply for RFA HS 10 014 Funding Number: RFA HS 10 014 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $16,660,000 |
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