Opportunity Information: Apply for RFA HS 10 020

  • The Agency for Health Care Research and Quality in the health recovery act sector is offering a public funding opportunity titled "ARRA OS Recovery Act 2009 Limited Competition Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01)" and is now available to receive applicants.
  • This funding opportunity was created on Jan 21, 2010 and posted on Jan 21, 2010.
  • Applicants must submit their applications by Mar 29, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $24,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $4,000,000.00 in funding.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) State governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education City or township governments Public and State controlled institutions of higher education County governments.
  • Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Indian/Native American Tribal Governments (Other than Federally Recognized).
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Opportunity Summary:

The ARRA OS Recovery Act 2009 Limited Competition Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01) funding opportunity (RFA-HS-10-020) was issued by the Agency for Healthcare Research and Quality (AHRQ) using funds provided through the Office of the Secretary (OS) under the American Recovery and Reinvestment Act of 2009 (ARRA). Its central goal was to strengthen the nation s ability to generate real-world evidence about which healthcare interventions work best for which patients by improving the data infrastructure and methods behind clinical registries and other electronic clinical data sources. Rather than focusing primarily on a single clinical trial or a narrow research question, the emphasis was on building and enhancing the systems and approaches needed to collect prospective data from electronic clinical databases, so that those data could reliably support comparative effectiveness research and quality improvement at scale.

In practical terms, applicants were expected to propose projects that develop or expand registry infrastructure and upgrade the methodology for capturing, standardizing, and using clinical data drawn from electronic sources such as electronic health records and related clinical databases. The intent was to enable the creation of new evidence about comparative effectiveness, meaning evidence that compares outcomes across different treatments, procedures, care strategies, or delivery models as they are used in routine practice. The opportunity was framed as a limited competition, signaling that it was not an open-ended call for any topic, but rather a targeted ARRA investment designed to quickly accelerate capacity for evidence generation using enhanced registries and improved prospective data collection.

This was a discretionary grant opportunity using the NIH style Research Project Grant (R01) mechanism. AHRQ announced an estimated total funding level of $24,000,000, with an award ceiling of $4,000,000 per award. No cost sharing or matching was required, which reduced barriers for applicants that might otherwise struggle to provide non-federal funds. The funding activity category was listed under Health and tied explicitly to the Recovery Act, reflecting the ARRA focus on near-term impact and infrastructure that could produce usable evidence more rapidly than traditional research pathways alone.

Eligibility was broad and included multiple levels of government and a wide range of organizational types. Eligible applicants included state governments, county governments, and city or township governments, as well as public and state controlled institutions of higher education and private institutions of higher education. Federally recognized Native American tribal governments were eligible, along with other tribal organizations, and additional eligible applicants referenced in the announcement included eligible federal agencies and faith-based or community-based organizations. The listing of "Others (see text field entitled Additional Information on Eligibility for clarification)" indicates that AHRQ intended to allow participation by a diverse set of entities that could realistically build or operate registries and clinical data infrastructure, including organizations closely connected to healthcare delivery systems and patient populations.

Key administrative details show the opportunity timeline and where to find the full announcement. The FOA was posted and created on January 21, 2010, with an original and current closing date of March 29, 2010, and it was archived on April 29, 2010. The full announcement was made available through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-HS-10-020.html. For access or technical linking issues, the contact point provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

Overall, this grant opportunity was designed as a one-time ARRA-funded push to enhance registry-based and electronic clinical data capabilities so that researchers and health system partners could produce stronger, more timely comparative effectiveness evidence and directly support quality improvement efforts. The combination of infrastructure development, methodological improvement, and prospective data collection from electronic clinical sources reflects a deliberate move toward learning health system approaches where data generated during care can be transformed into actionable evidence about outcomes, safety, and value across competing healthcare options.

FAQs: ARRA OS Recovery Act 2009 Limited Competition Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01) - RFA-HS-10-020

What is this funding opportunity?

This opportunity is the ARRA OS Recovery Act 2009 Limited Competition Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01) funding opportunity, identified as RFA-HS-10-020. It was issued by the Agency for Healthcare Research and Quality (AHRQ) using funds provided through the Office of the Secretary (OS) under the American Recovery and Reinvestment Act of 2009 (ARRA).

What is the main goal of the program?

The central goal was to strengthen the nation's ability to generate real-world evidence about which healthcare interventions work best for which patients. It aimed to do this by improving the data infrastructure and methods behind clinical registries and other electronic clinical data sources, so they can support comparative effectiveness research and quality improvement at scale.

What type of research or work was emphasized?

The emphasis was on building and enhancing systems and approaches needed to collect prospective data from electronic clinical databases (such as electronic health records and related clinical databases). The intent was to make those data reliable for comparative effectiveness research and large-scale quality improvement.

Was this opportunity focused on single clinical trials?

No. Rather than focusing primarily on a single clinical trial or a narrow research question, the opportunity prioritized strengthening registry infrastructure and improving methods for capturing, standardizing, and using electronically sourced clinical data.

What kinds of projects were applicants expected to propose?

Applicants were expected to propose projects that develop or expand registry infrastructure and upgrade methodologies for capturing, standardizing, and using clinical data drawn from electronic sources such as electronic health records and related clinical databases. The overall intent was to enable new comparative effectiveness evidence based on routine practice.

What is meant by "comparative effectiveness" in this announcement?

Comparative effectiveness evidence refers to evidence comparing outcomes across different treatments, procedures, care strategies, or delivery models as they are used in routine practice.

What does "limited competition" mean for this FOA?

The opportunity was framed as a limited competition, meaning it was not an open-ended call for any topic. It was described as a targeted ARRA investment designed to quickly accelerate national capacity for evidence generation using enhanced registries and improved prospective data collection.

What grant mechanism was used?

This was a discretionary grant opportunity using the NIH-style Research Project Grant (R01) mechanism.

Which agency issued the funding opportunity?

The funding opportunity was issued by AHRQ, and the funds were provided through the Office of the Secretary (OS) under ARRA.

What was the estimated total funding available?

AHRQ announced an estimated total funding level of $24,000,000 for this opportunity.

Was there a maximum award amount?

Yes. The award ceiling was $4,000,000 per award.

Was cost sharing or matching required?

No. No cost sharing or matching was required.

What was the funding activity category?

The funding activity category was listed under Health and was tied explicitly to the Recovery Act (ARRA).

Who was eligible to apply?

Eligibility was broad and included multiple levels of government and a wide range of organizational types. Eligible applicants included state governments, county governments, and city or township governments, as well as public and state-controlled institutions of higher education and private institutions of higher education.

Were tribal entities eligible?

Yes. Federally recognized Native American tribal governments were eligible, along with other tribal organizations.

Were federal agencies eligible?

Yes. The announcement referenced eligible federal agencies as eligible applicants.

Could faith-based or community-based organizations apply?

Yes. Faith-based or community-based organizations were included among eligible applicants.

What does "Others (see text field entitled Additional Information on Eligibility for clarification)" imply?

It indicates that AHRQ intended to allow participation by a diverse set of entities beyond the standard categories, particularly organizations that could realistically build or operate registries and clinical data infrastructure and that are connected to healthcare delivery systems and patient populations.

When was the FOA posted?

The FOA was posted and created on January 21, 2010.

What was the application due date?

The original and current closing date was March 29, 2010.

When was the opportunity archived?

The opportunity was archived on April 29, 2010.

Where could applicants find the full announcement?

The full announcement was available through the NIH grants guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HS-10-020.html.

Who was listed as a contact for access or technical linking issues?

For access or technical linking issues, the contact provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

What was the broader purpose of using ARRA funds for this program?

This was described as a one-time ARRA-funded push to enhance registry-based and electronic clinical data capabilities so researchers and health system partners could produce stronger, more timely comparative effectiveness evidence and directly support quality improvement efforts.

How does this opportunity relate to learning health system approaches?

The described focus on infrastructure development, methodological improvement, and prospective data collection from electronic clinical sources reflects a move toward learning health system approaches, where data generated during care can be transformed into actionable evidence about outcomes, safety, and value across competing healthcare options.

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