Opportunity Information: Apply for RFA OD 10 012

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "ARRA OS Recovery Act Limited Competition Impact of Decision Support Systems on the Dissemination and Adoption of Imaging Related Comparative Effectiveness Findings (UC4)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.701 Trans NIH Recovery Act Research Support.
  • This funding opportunity was created on Mar 10, 2010 and posted on Mar 10, 2010.
  • Applicants must submit their applications by May 5, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • The number of recipients for this funding is limited to 2 candidate(s).
  • Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education City or township governments State governments Independent school districts Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Others (see text field entitled Additional Information on Eligibility for clarification).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The grant opportunity titled "ARRA OS Recovery Act Limited Competition Impact of Decision Support Systems on the Dissemination and Adoption of Imaging Related Comparative Effectiveness Findings (UC4)" was a National Institutes of Health (NIH) funding announcement created under the American Recovery and Reinvestment Act of 2009 (ARRA), also known as the Recovery Act (Public Law 111-5). Its central goal was to fund projects that examine how clinical decision support systems can help spread and increase real-world use of comparative effectiveness research (CER) findings specifically related to medical imaging. In practical terms, the opportunity focused on whether real-time decision support tools, integrated into clinical workflows, can influence clinicians to consider and apply evidence about what imaging strategies work best, for whom, and under what circumstances.

A key feature of this announcement is that it was not just about generating more comparative effectiveness evidence. Instead, it targeted the downstream problem of implementation: getting existing CER findings into the hands of clinicians at the moment decisions are made. The FOA emphasized implementing and assessing real-time decision support systems, meaning tools that can deliver patient- and context-relevant guidance during ordering, interpretation, or management decisions involving imaging. The underlying idea was that if these tools prove effective in routine care settings, they could be adopted more broadly across health systems, helping translate research findings into consistent practice.

The mechanism used was a Cooperative Agreement under the UC4 activity code, which typically implies substantial NIH involvement compared with a standard research project grant. Under a cooperative agreement, the funded teams and the NIH generally collaborate more actively on project direction, milestones, coordination, and evaluation expectations. This makes sense for an initiative centered on deploying operational clinical systems and measuring their effects, where shared standards, cross-site coordination, and rigorous assessment methods are often important to produce results that generalize beyond a single institution.

Funding for the program was capped at an estimated total of 3,000,000 dollars, with NIH expecting to make about two awards in fiscal year 2010, depending on application quality and funds availability. The award ceiling listed was 500,000 dollars, and the opportunity did not require cost sharing or matching. The funding instrument type was a cooperative agreement and the activity category was health. The CFDA number associated with the program was 93.701, identified as Trans-NIH Recovery Act Research Support, reflecting that ARRA funding was being used to support research activities across NIH.

The opportunity was posted and created on March 10, 2010, with an original and current closing date of May 5, 2010, and an archive date of June 5, 2010. In other words, it was a time-limited ARRA-era competition with a short submission window, consistent with Recovery Act programs that were designed to stimulate rapid activity and measurable impact.

Eligibility was broad and included many types of U.S.-based organizations. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, with institutions of higher education separately recognized), for-profit organizations (other than small businesses as well as small businesses), and multiple levels of government (state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities). It also included Native American tribal governments (both federally recognized and other than federally recognized) and Native American tribal organizations. Additional eligible categories listed included Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This wide eligibility reflects an interest in attracting projects from diverse healthcare delivery environments, including safety-net systems, academic medical centers, tribal health organizations, and other settings where imaging decisions and evidence implementation challenges may differ.

Administratively, the sponsoring agency was the NIH, with program funding intentions referenced through NIBIB (the National Institute of Biomedical Imaging and Bioengineering) committing up to the total funding amount stated. The funding opportunity number was RFA-OD-10-012, and the full announcement was hosted on the NIH Grants Guide website. For access or technical issues, the contact listed was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

Overall, this FOA can be read as a targeted implementation and evaluation initiative: it sought to push imaging-related comparative effectiveness findings into everyday clinical decision-making through real-time clinical decision support, then rigorously study whether doing so actually changes consideration and adoption of evidence in practice. The broader policy context was ARRA, which placed emphasis on accelerating research, modernizing health infrastructure, and producing practical, near-term benefits, making decision support for evidence-based imaging a natural fit for the program’s goals.

Frequently Asked Questions (FAQs)

What is the title of this grant opportunity?

The opportunity is titled "ARRA OS Recovery Act Limited Competition Impact of Decision Support Systems on the Dissemination and Adoption of Imaging Related Comparative Effectiveness Findings (UC4)."

Which agency sponsored this funding opportunity?

The sponsoring agency was the National Institutes of Health (NIH).

What is the funding opportunity number?

The funding opportunity number is RFA-OD-10-012.

What law or program created the funding source for this opportunity?

This announcement was created under the American Recovery and Reinvestment Act of 2009 (ARRA), also known as the Recovery Act (Public Law 111-5).

What is the main purpose of this opportunity?

The central goal was to fund projects that examine how clinical decision support systems can help disseminate and increase real-world adoption of comparative effectiveness research (CER) findings related specifically to medical imaging.

Is this opportunity focused on generating new comparative effectiveness research evidence?

No. The emphasis was not on creating new CER findings. It targeted implementation: getting existing imaging-related CER findings into routine clinical decision-making.

What does the opportunity mean by "real-time decision support systems"?

It refers to tools integrated into clinical workflows that can deliver patient- and context-relevant guidance at the moment decisions are made, such as during imaging ordering, interpretation, or management decisions involving imaging.

What kinds of outcomes or effects was the program trying to study?

The program aimed to assess whether integrated, real-time decision support tools can influence clinicians to consider and apply evidence about which imaging strategies work best, for whom, and under what circumstances, and whether this leads to greater dissemination and adoption of imaging-related CER findings in practice.

What funding mechanism was used?

The mechanism was a Cooperative Agreement under the UC4 activity code.

What is notable about a UC4 cooperative agreement compared with a standard grant?

A UC4 cooperative agreement typically involves substantial NIH involvement. Funded teams and NIH may collaborate more actively on project direction, milestones, coordination, and evaluation expectations, which aligns with projects deploying operational clinical systems and measuring their effects.

What is the activity category for this opportunity?

The activity category was health.

What is the CFDA number for this program?

The CFDA number was 93.701, identified as Trans-NIH Recovery Act Research Support.

How much total funding was expected to be available?

Total funding was capped at an estimated 3,000,000 dollars.

How many awards did NIH expect to make?

NIH expected to make about two awards in fiscal year 2010, depending on application quality and the availability of funds.

What was the maximum award amount listed?

The award ceiling listed was 500,000 dollars.

Was cost sharing or matching required?

No. The opportunity did not require cost sharing or matching.

When was the opportunity posted?

The opportunity was posted and created on March 10, 2010.

What was the application deadline?

The original and current closing date was May 5, 2010.

When was the opportunity archived?

The archive date was June 5, 2010.

Was this a time-limited competition?

Yes. It had a short submission window and was positioned as a limited, ARRA-era competition.

Who was eligible to apply?

Eligibility was broad and included many U.S.-based organizations, including public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (including small businesses and other than small businesses); and multiple levels of government (state, county, city or township, special district, independent school districts, and public housing authorities/Indian housing authorities).

Were tribal entities and tribal organizations eligible?

Yes. Eligible applicants included Native American tribal governments (federally recognized and other than federally recognized) and Native American tribal organizations.

Were minority-serving institutions and community-based organizations eligible?

Yes. The eligibility list included Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, among other categories.

Were U.S. territories or possessions eligible?

Yes. U.S. territories or possessions were included among eligible applicants.

Which NIH institute was referenced for funding intentions?

Program funding intentions were referenced through NIBIB (the National Institute of Biomedical Imaging and Bioengineering), which was noted as committing up to the total funding amount stated.

What broader policy context shaped this funding opportunity?

The broader context was ARRA, which emphasized accelerating research, modernizing health infrastructure, and producing practical near-term benefits. Within that context, decision support to implement evidence-based imaging was positioned as a way to translate existing research findings into consistent clinical practice.

Where was the full announcement hosted?

The full announcement was hosted on the NIH Grants Guide website.

Who was the contact for access or technical issues?

For access or technical issues, the contact listed was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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