Opportunity Information: Apply for RFA AI 15 032
Apply for RFA AI 15 032
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Asthma and Allergic Diseases Cooperative Research Centers (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jun 3, 2015 and posted on Jun 3, 2015.
- Applicants must submit their applications by Oct 2, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $10,800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized) State governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Small businesses City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) (U19) opportunity (Funding Opportunity Number RFA-AI-15-032) is a National Institutes of Health cooperative agreement designed to fund multidisciplinary research centers focused on asthma and a range of allergic diseases. The central idea is to support programs that deliberately integrate clinical research with basic and translational science so investigators can study, in a coordinated way, the biological and immunologic mechanisms that drive how these conditions begin, worsen, and progress over time. Rather than funding isolated projects, this mechanism is built for center-style efforts where multiple linked research components can share infrastructure, patient populations, samples, methods, and scientific direction while working toward a common set of objectives.
The research scope is broad across respiratory and allergic conditions, specifically including asthma; rhinitis (both allergic and non-allergic); chronic rhinosinusitis; atopic dermatitis; food allergy; and drug allergy. Within that disease scope, the FOA emphasizes work that explains underlying mechanisms of disease onset and progression, with the expectation that mechanistic understanding will point toward better prevention approaches, improved diagnostics, and more effective treatments. In practice, this kind of program typically supports studies that connect patient-oriented observations (such as clinical phenotypes, triggers, and outcomes) with laboratory-based discovery (such as immune pathways, barrier function, genetics, microbiome-related effects, or inflammatory mediators), with the goal of producing a rational, evidence-based foundation for new interventions.
Because the award is a cooperative agreement (U19), NIH is expected to have substantial programmatic involvement compared with a standard research project grant. That generally means the centers operate in partnership with NIH staff, with an emphasis on coordination, shared milestones, and active collaboration. The FOA invites applications from either single institutions or consortia of institutions, reflecting that successful center programs may be built within one organization or deliberately assembled across multiple organizations to bring together complementary expertise, patient access, and specialized capabilities.
Funding details in the announcement indicate an estimated total funding amount of $10,800,000, with an award ceiling of $900,000. There is no cost sharing or matching requirement stated. The opportunity was posted June 3, 2015, with an original and current closing date of October 2, 2015, and an archive date of November 2, 2015. The associated CFDA numbers are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), signaling the program’s placement within NIH’s allergy, immunology, and infectious disease research portfolios.
Eligibility is intentionally broad and includes many types of U.S.-based applicants across academia, government, nonprofit, and industry. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status (including those outside universities), for-profit organizations other than small businesses, small businesses, and a range of governmental entities (state, county, city or township, special district governments, and independent school districts). Tribal entities are included as well, such as federally recognized Native American tribal governments and tribal organizations other than federally recognized governments, along with tribally controlled colleges and universities. The eligibility section also notes inclusion of institutions serving specific populations, such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Asian American and Native American Pacific Islander-serving institutions, and faith-based or community-based organizations, as well as eligible federal agencies and U.S. territories or possessions.
The FOA makes a clear distinction regarding foreign participation. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply. However, foreign components, as defined by the NIH Grants Policy Statement, are allowed, which typically means a U.S. applicant can include certain scientifically justified foreign collaborations or elements within the project structure while maintaining a U.S.-based applicant organization and leadership.
For applicants looking for the full official announcement and detailed requirements, the FOA provides an NIH link to the archived funding notice: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-032.html. For technical issues accessing the announcement or linking to it, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Asthma and Allergic Diseases Cooperative Research Centers (AADCRC) (U19) opportunity?
The AADCRC (U19) opportunity (Funding Opportunity Number RFA-AI-15-032) is a National Institutes of Health (NIH) cooperative agreement intended to fund multidisciplinary research centers focused on asthma and a range of allergic diseases. It is structured to support coordinated, center-style programs rather than isolated, stand-alone projects.
What type of NIH funding mechanism is used for this opportunity?
This opportunity uses a cooperative agreement mechanism (U19). In a cooperative agreement, NIH is expected to have substantial programmatic involvement compared with a standard research project grant, emphasizing partnership, coordination, shared milestones, and active collaboration.
What is the main goal of the AADCRC (U19) program?
The central goal is to support research programs that deliberately integrate clinical research with basic and translational science so investigators can study, in a coordinated way, the biological and immunologic mechanisms that drive how asthma and allergic diseases begin, worsen, and progress over time.
Why does the FOA emphasize a center-style approach instead of individual projects?
The mechanism is designed for multiple linked research components that can share infrastructure, patient populations, samples, methods, and scientific direction while working toward a common set of objectives, enabling coordinated studies of disease mechanisms and progression.
Which diseases and conditions are specifically included in the research scope?
The FOA specifically includes asthma; rhinitis (both allergic and non-allergic); chronic rhinosinusitis; atopic dermatitis; food allergy; and drug allergy.
What kinds of research questions does the FOA prioritize?
The FOA emphasizes work that explains underlying mechanisms of disease onset and progression, with the expectation that mechanistic understanding can inform better prevention approaches, improved diagnostics, and more effective treatments.
How does the FOA describe the integration of clinical and laboratory research?
The FOA supports programs that connect patient-oriented observations (for example, clinical phenotypes, triggers, and outcomes) with laboratory-based discovery (for example, immune pathways, barrier function, genetics, microbiome-related effects, or inflammatory mediators) to build an evidence-based foundation for new interventions.
Can an application be submitted by a single institution, or does it need to be a consortium?
Applications may be submitted by either a single institution or a consortium of institutions. The FOA reflects that successful center programs may be built within one organization or assembled across multiple organizations to bring together complementary expertise, patient access, and specialized capabilities.
What is the estimated total funding amount for this opportunity?
The announcement indicates an estimated total funding amount of $10,800,000.
What is the award ceiling for an individual award under this FOA?
The award ceiling is $900,000.
Is cost sharing or matching required?
No cost sharing or matching requirement is stated in the provided information.
When was this funding opportunity posted, and what were the key dates?
The opportunity was posted on June 3, 2015. The original and current closing date was October 2, 2015, and the archive date was November 2, 2015.
What are the CFDA numbers associated with this opportunity?
The associated CFDA numbers are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based applicants across academia, government, nonprofit, and industry. Eligible applicants listed include public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status (including those outside universities); for-profit organizations other than small businesses; small businesses; and multiple governmental entities (state, county, city or township, special district governments, and independent school districts).
Are tribal entities eligible to apply?
Yes. The eligibility list includes federally recognized Native American tribal governments, tribal organizations other than federally recognized governments, and tribally controlled colleges and universities.
Are institutions that serve specific populations included in the eligibility list?
Yes. The eligibility section notes inclusion of institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Asian American and Native American Pacific Islander-serving institutions, as well as faith-based or community-based organizations.
Are federal agencies and U.S. territories or possessions eligible?
Yes. The eligibility section includes eligible federal agencies and U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible to apply as the applicant?
No. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply, based on the provided information.
Are foreign components allowed in an application led by a U.S. applicant?
Yes. Foreign components, as defined by the NIH Grants Policy Statement, are allowed. This typically means a U.S. applicant can include scientifically justified foreign collaborations or elements while maintaining a U.S.-based applicant organization and leadership.
Where can applicants find the official (archived) FOA announcement?
The FOA provides an NIH link to the archived funding notice: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-15-032.html.
Who should be contacted for technical issues accessing the FOA link?
For technical issues accessing the announcement or linking to it, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What does NIH programmatic involvement mean in practical terms for a U19 center?
Based on the provided description, it means the centers operate in partnership with NIH staff, with an emphasis on coordination, shared milestones, and active collaboration, rather than operating fully independently as in a standard research project grant.
What is the intended scientific outcome of focusing on mechanisms of onset and progression?
The FOA indicates that mechanistic understanding is expected to point toward better prevention approaches, improved diagnostics, and more effective treatments across the included asthma and allergic disease areas.
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