Opportunity Information: Apply for N62645 PA 13 1
Apply for N62645 PA 13 1
- The NAVAL MEDICAL LOGISTICS COMMAND in the science and technology and other research and development sector is offering a public funding opportunity titled "Austere Environment Consortium for Enhanced Sepsis Outcomes (ACESO) Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.340 Naval Medical Research and Development.
- This funding opportunity was created on Jul 18, 2013 and posted on Jul 18, 2013.
- Applicants must submit their applications by Aug 30, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $26,300,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Austere Environment Consortium for Enhanced Sepsis Outcomes (ACESO) Award is a U.S. Navy research funding opportunity designed to build a coordinated, multi-institution consortium focused on severe sepsis in austere and resource-limited settings. Led by the Department of the Navy's Bureau of Medicine and Surgery (BUMED) through the Naval Medical Research Center (NMRC), the program targets practical advances in prevention, early recognition, diagnosis, and treatment of severe sepsis from any cause, with an emphasis on work that can be translated quickly into better outcomes where medical resources, staffing, laboratory capability, and evacuation options may be limited. The core idea is to create a standing research platform that can operate in challenging environments and generate usable evidence for frontline clinical decision-making as well as for military medical planning.
A central priority of ACESO is addressing sepsis caused by infectious agents that currently lack specific therapies and that present heightened military relevance due to outbreak potential, risks to deployed forces, and deliberate use scenarios. The announcement specifically highlights viral hemorrhagic fevers (VHF) as an example of threats that can present as severe sepsis and demand specialized understanding and preparedness. By focusing on these etiologies, the consortium is meant to strengthen Department of Defense capabilities not only for routine severe sepsis management in difficult settings, but also for biological threats that can rapidly overwhelm local care capacity and require rapid clinical characterization during emergent events.
The program envisions a networked consortium of investigators and operational partners with complementary expertise, including infectious disease, critical care, systems biology, and global health, among other relevant fields. Rather than funding isolated projects, ACESO is structured to support coordinated research across sites and disciplines, backed by trained study staff and in-country infrastructure. This infrastructure is intended to enable both planned studies and responsive data collection during outbreaks, when time-sensitive clinical information is often hard to capture but crucial for improving care and understanding disease progression.
Research activities under ACESO are expected to span several interconnected areas. These include evaluating clinical management strategies for severe sepsis in austere environments, studying the pathogenesis of severe sepsis, and characterizing clinical presentations linked to potential biological threats. The consortium is also expected to investigate immunopathogenesis and longer-term sequelae of infectious causes of severe sepsis, with particular emphasis on hemorrhagic fevers. Another key objective is improving the ability to gather high-quality clinical data during outbreaks of severe emerging diseases, which supports both near-term operational decisions and longer-term development of countermeasures and clinical guidelines.
From an award and administration standpoint, ACESO is funded as a cooperative agreement, meaning the recipient is expected to work closely with the U.S. Government during execution rather than operating with the more hands-off structure typical of many grants. The award is issued between the recipient, designated as the ACESO Coordinator, and the Government through the Naval Medical Logistics Command (NMLC). The opportunity anticipates a single award with a five-year performance period, reflecting the intent to establish a durable consortium rather than a short, standalone effort.
Key funding and eligibility details indicate a substantial investment and broad eligibility. The funding opportunity number is N62645-PA-13-1, categorized as discretionary funding for science and technology and other research and development activities under CFDA 12.340 (Naval Medical Research and Development). The estimated total funding amount is $26,300,000, cost sharing is not required, and eligibility is listed as unrestricted (open to any type of entity, subject to any additional eligibility clarifications in the full announcement). The opportunity was posted on July 18, 2013, with an original and current closing date of August 30, 2013, and an archive date of September 29, 2013. For access issues related to the full announcement, the contact listed is the NMLC RSD Help Desk.
ACESO Award (N62645-PA-13-1) - Frequently Asked Questions
1) What is the ACESO Award?
The Austere Environment Consortium for Enhanced Sepsis Outcomes (ACESO) Award is a U.S. Navy research funding opportunity intended to establish a coordinated, multi-institution consortium focused on severe sepsis in austere and resource-limited settings.
2) What is the main goal of ACESO?
The main goal is to create a standing research platform that can operate in challenging environments and produce practical, usable evidence to improve prevention, early recognition, diagnosis, and treatment of severe sepsis, especially where medical resources, staffing, laboratory capability, and evacuation options are limited.
3) Who is leading and sponsoring this opportunity?
The program is led by the Department of the Navy's Bureau of Medicine and Surgery (BUMED) through the Naval Medical Research Center (NMRC).
4) What type of award is ACESO?
ACESO is funded as a cooperative agreement. This means the recipient is expected to work closely with the U.S. Government during execution, rather than operating under a more hands-off grant structure.
5) Who will hold the award?
The award is issued between the recipient, designated as the ACESO Coordinator, and the Government through the Naval Medical Logistics Command (NMLC).
6) Is ACESO intended to fund a single project or multiple coordinated efforts?
ACESO is structured to support coordinated research across sites and disciplines rather than isolated projects, with the intent of building a networked, multi-institution consortium.
7) How many awards are anticipated?
The opportunity anticipates a single award, reflecting the intent to establish a durable consortium rather than multiple separate awards.
8) What is the performance period for the award?
The anticipated performance period is five years.
9) What is the estimated total funding amount?
The estimated total funding amount is $26,300,000.
10) Is cost sharing required?
No. Cost sharing is not required.
11) What is the funding opportunity number?
The funding opportunity number is N62645-PA-13-1.
12) What is the CFDA number associated with this opportunity?
The opportunity is listed under CFDA 12.340 (Naval Medical Research and Development).
13) What kind of funding category is this?
It is categorized as discretionary funding for science and technology and other research and development activities.
14) Who is eligible to apply?
Eligibility is listed as unrestricted, meaning it is open to any type of entity, subject to any additional eligibility clarifications that may appear in the full announcement.
15) What research focus areas does ACESO support?
Research under ACESO is expected to address prevention, early recognition, diagnosis, and treatment of severe sepsis from any cause, with an emphasis on approaches that can be translated quickly into better outcomes in austere and resource-limited settings.
16) Why does the announcement emphasize austere and resource-limited settings?
The program is designed for situations where medical resources, staffing, laboratory capability, and evacuation options may be limited, and where evidence is needed to support frontline clinical decision-making and military medical planning.
17) Are biological threats and outbreak scenarios part of the scope?
Yes. A central priority is addressing sepsis caused by infectious agents that currently lack specific therapies and that have heightened military relevance due to outbreak potential, risks to deployed forces, and deliberate use scenarios.
18) Does the opportunity mention specific diseases or threat examples?
Yes. The announcement specifically highlights viral hemorrhagic fevers (VHF) as an example of threats that can present as severe sepsis and require specialized understanding and preparedness.
19) What disciplines and expertise are expected within the consortium?
The envisioned consortium includes investigators and operational partners with complementary expertise such as infectious disease, critical care, systems biology, and global health, among other relevant fields.
20) What types of activities or capabilities are expected beyond typical research studies?
The consortium is expected to be supported by trained study staff and in-country infrastructure to enable both planned studies and responsive data collection during outbreaks, when time-sensitive clinical information can be difficult to capture.
21) What kinds of research activities are expected within ACESO?
Expected activities include evaluating clinical management strategies for severe sepsis in austere environments, studying sepsis pathogenesis, and characterizing clinical presentations linked to potential biological threats.
22) Does ACESO include immunology and longer-term outcomes research?
Yes. The consortium is expected to investigate immunopathogenesis and longer-term sequelae of infectious causes of severe sepsis, with particular emphasis on hemorrhagic fevers.
23) Why is outbreak data collection a stated objective?
Improving the ability to gather high-quality clinical data during outbreaks of severe emerging diseases is described as a key objective, supporting near-term operational decisions and longer-term development of countermeasures and clinical guidelines.
24) What are the key dates for this opportunity?
The opportunity was posted on July 18, 2013. The original and current closing date is August 30, 2013. The archive date is September 29, 2013.
25) Where should applicants go if they cannot access the full announcement?
For access issues related to the full announcement, the contact listed is the NMLC RSD Help Desk.
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