Avenir Award Program for Genetics or Epigenetics of Substance Abuse (DP1) | Apply Online

Opportunity Summary:

The Avenir Award Program for Genetics or Epigenetics of Substance Abuse (DP1) is a National Institutes of Health (NIH) discretionary grant opportunity aimed at supporting research connected to the genetics or epigenetics of substance abuse and addiction. This particular Funding Opportunity Announcement (FOA), numbered RFA-DA-16-007, specifically notes that it replaces an earlier version of the Avenir program that used a DP2 mechanism (RFA-DA-15-006) and shifts the award structure to a DP1 mechanism. In practical terms, that means NIH is continuing the Avenir initiative but doing it under a different grant mechanism, which typically signals changes in how the award is positioned within NIH's portfolio (for example, how it is administered and how it is categorized), while keeping the overall scientific theme focused on genetics and epigenetics in substance abuse research.

From a funding standpoint, the FOA lists an estimated total funding amount of $1,500,000, with an award ceiling of $300,000. There is no cost sharing or matching requirement, which is important because applicants are not expected to bring non-federal funds to meet a mandatory match. The opportunity sits under the Health funding activity category and is associated with CFDA number 93.279, which corresponds to Drug Abuse and Addiction Research Programs. The funding instrument type is a grant, and the opportunity is categorized as discretionary, meaning it is awarded through a competitive process based on the FOA requirements and peer review.

The timeline provided in the source data shows the FOA was posted and created on August 12, 2015. The original closing date and the current closing date are both listed as October 20, 2016, and the archive date is November 20, 2016. That set of dates indicates the solicitation is no longer active now, but the details still matter for understanding what NIH supported under this program and for tracking how the program evolved from the earlier DP2 version to the DP1 version.

Eligibility under this FOA is broad and spans many types of domestic organizations. Eligible applicants include state, county, city or township governments; special district governments; and independent school districts. It also includes public and state-controlled institutions of higher education as well as private institutions of higher education. The FOA allows nonprofit organizations both with and without 501(c)(3) IRS status (with the non-501(c)(3) category explicitly excluding institutions of higher education), and it also allows for-profit organizations other than small businesses, in addition to small businesses themselves. Public housing authorities and Indian housing authorities are included as well. Tribal eligibility is addressed in multiple categories: federally recognized Native American tribal governments are eligible, and Native American tribal organizations that are not federally recognized are also listed among eligible applicants. The FOA further clarifies eligibility by naming additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Regional organizations, U.S. territories or possessions, and eligible federal agencies are also included, and the FOA explicitly states that faith-based or community-based organizations may apply, which is a common NIH inclusion intended to avoid excluding applicants based solely on organizational identity when they otherwise meet program and policy requirements.

At the same time, the FOA is clear about what is not allowed on the applicant side. Non-domestic (non-U.S.) entities, meaning foreign institutions, are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as NIH defines them in the NIH Grants Policy Statement) are not allowed. This matters for universities or nonprofits with overseas branches or formal foreign subcomponents, because it signals that the project must remain within the domestic eligibility framework without foreign components under NIH policy.

For applicants or readers who want the official NIH announcement text, the FOA points to an NIH Grants Guide link: http://grants.nih.gov/grants/guide/rfa-files/RFA-DA-16-007.html. For technical issues accessing the announcement, NIH lists the Office of Extramural Research (OER) Webmaster contact (FBOWebmaster@OD.NIH.GOV), including help both for accessing the full announcement and for problems linking to the funding notice.

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