Opportunity Information: Apply for RFA AG 10 004
Apply for RFA AG 10 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Awards to Support Research on the Biology of Aging in Invertebrates (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jul 17, 2009 and posted on Jul 17, 2009.
- Applicants must submit their applications by Oct 30, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institute on Aging (NIA) at the National Institutes of Health announced this R01 funding opportunity (RFA-AG-10-004) to push aging research beyond the usual invertebrate workhorses and into newer, underdeveloped species that could reveal fresh biology. The central goal is to identify, develop, and rigorously characterize new short-lived invertebrate models that can be used to study fundamental mechanisms of aging. NIA is especially interested in species where researchers can realistically build modern experimental toolkits, such as workable genetics, an available or actively developing genome sequence, and practical laboratory methods for manipulating and measuring aging-related traits.
A major emphasis is on invertebrates that offer unusual or informative aging features, particularly negligible senescence, experimentally induced senescence, or robust adult tissue regeneration. The announcement highlights planaria, hydra, rotifers, and tunicates as examples of the kinds of organisms NIA wants to see brought into the mainstream of aging biology, largely because these systems may help explain how longevity, regeneration, and tissue maintenance can be sustained over time. At the same time, the FOA leaves the door open to other invertebrate species already used somewhere in biomedical research but not yet fully developed or widely adopted for aging studies; those would still be considered responsive if the application clearly advances them as aging models.
From a scientific scope standpoint, the work should go beyond simply describing an organism and instead build a compelling platform for aging research. Competitive applications would typically propose molecular, genetic, cellular, and/or physiological approaches that establish the organism as a practical system for discovering mechanisms of longevity and senescence. NIA explicitly encourages studies aimed at identifying genes and pathways involved in lifespan determination, cellular senescence-like processes, and tissue homeostasis during aging, which includes how tissues are maintained, repaired, or regenerated as the organism grows older. In other words, the aim is to create or strengthen an experimental model where aging can be measured, manipulated, and mechanistically dissected, not just observed.
The FOA also draws a clear boundary around what it will not support. Proposals centered on the standard, already highly developed invertebrate aging models Caenorhabditis elegans, Drosophila melanogaster, or the yeast Saccharomyces cerevisiae are considered non-responsive, meaning they fall outside the intent of this call even if the proposed science is related to aging. The purpose here is capacity-building and discovery in less mature model systems, rather than incremental work in established platforms.
In terms of funding structure, this opportunity uses the NIH R01 mechanism, supporting hypothesis-driven research projects that can run for up to five years. For fiscal year 2010, NIA set aside a total of about $2.0 million for this initiative, with an anticipated 5 to 6 awards. The listed award ceiling is $250,000. There is no cost sharing or matching requirement.
Eligibility is broad and includes many organization types commonly able to apply for NIH grants. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (both with and without 501(c)(3) status), federally recognized Native American tribal governments, and other tribal organizations. The announcement also notes additional eligible categories such as Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, eligible federal agencies, and U.S. territories or possessions.
Key administrative details place this as a time-limited, archived opportunity that was posted July 17, 2009, with an original (and final) closing date of October 30, 2009, and an archive date of November 30, 2009. The CFDA number tied to the program area is 93.866 (Aging Research). For technical issues accessing the full announcement, the listing provides the NIH Office of Extramural Research (OER) webmaster contact (FBOWebmaster@OD.NIH.GOV) and links to the full FOA on the NIH grants site.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a National Institute on Aging (NIA), National Institutes of Health (NIH) R01 funding opportunity announcement: RFA-AG-10-004. It supports research projects aimed at creating and strengthening new, short-lived invertebrate model systems for studying fundamental mechanisms of aging.
What is the main goal of RFA-AG-10-004?
The central goal is to identify, develop, and rigorously characterize new short-lived invertebrate models that can be used to study basic mechanisms of aging. The emphasis is on moving beyond the standard invertebrate "workhorse" models and building capacity in newer, underdeveloped species that may reveal new biology.
Why is NIA focusing on new invertebrate model organisms?
NIA is aiming to expand the range of experimental systems used in aging biology so researchers can explore aging, longevity, tissue maintenance, and regeneration in organisms with distinctive biology. The intent is to enable discovery in less mature model systems rather than incremental work in already highly developed platforms.
What kinds of invertebrate species are considered responsive to this FOA?
The FOA is especially interested in species where modern experimental toolkits are realistic to build, including workable genetics, an available or actively developing genome sequence, and practical lab methods for manipulating and measuring aging-related traits.
Does the FOA name any example organisms of interest?
Yes. The announcement highlights planaria, hydra, rotifers, and tunicates as examples of organisms NIA is interested in seeing developed into mainstream aging research models.
Are only the named organisms (planaria, hydra, rotifers, tunicates) eligible?
No. The FOA leaves the door open to other invertebrate species that may already be used in some biomedical research but are not yet fully developed or widely adopted for aging studies. Those can be responsive if the application clearly advances them as aging models.
What aging-related features are particularly encouraged in proposed model systems?
A major emphasis is on invertebrates that offer unusual or informative aging features, including negligible senescence, experimentally induced senescence, or robust adult tissue regeneration. These features are viewed as potentially informative for understanding longevity, regeneration, and long-term tissue maintenance.
What type of work is the FOA looking for scientifically?
The work is expected to go beyond simply describing an organism. Competitive applications would typically propose molecular, genetic, cellular, and/or physiological approaches that establish the organism as a practical platform for discovering mechanisms of longevity and senescence.
What kinds of research questions does NIA encourage under this FOA?
NIA explicitly encourages studies aimed at identifying genes and pathways involved in lifespan determination, cellular senescence-like processes, and tissue homeostasis during aging, including how tissues are maintained, repaired, or regenerated as the organism grows older.
What does NIA mean by building a "platform" for aging research?
Based on the FOA description, a platform implies an experimental model where aging can be measured, manipulated, and mechanistically dissected. The emphasis is on establishing practical tools and approaches that enable rigorous, hypothesis-driven aging research rather than simply observing aging-related phenomena.
Which model organisms are considered non-responsive to this FOA?
Proposals centered on the standard, already highly developed invertebrate aging models Caenorhabditis elegans, Drosophila melanogaster, or the yeast Saccharomyces cerevisiae are considered non-responsive to this call, even if the proposed work is related to aging.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which supports hypothesis-driven research projects.
What is the maximum project period allowed?
Projects can run for up to five years.
How much funding was set aside for this initiative?
For fiscal year 2010, NIA set aside about $2.0 million total for this initiative.
How many awards did NIA anticipate making?
NIA anticipated making approximately 5 to 6 awards.
What is the listed award ceiling?
The listed award ceiling is $250,000.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (with or without 501(c)(3) status). Eligibility also includes federally recognized Native American tribal governments and other tribal organizations.
Are minority-serving institutions and similar categories included as eligible applicants?
Yes. The announcement notes additional eligible categories such as Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are federal agencies and U.S. territories eligible to apply?
Yes. The opportunity lists eligible federal agencies and U.S. territories or possessions as eligible categories.
Is this a current, open funding opportunity?
No. This is a time-limited, archived opportunity.
When was the opportunity posted and when did it close?
It was posted on July 17, 2009. The original (and final) closing date was October 30, 2009. The archive date was November 30, 2009.
What CFDA number is associated with this program area?
The CFDA number tied to the program area is 93.866 (Aging Research).
Where can applicants find the full FOA details?
The listing indicates the full FOA is available on the NIH grants site (via links provided in the original announcement).
Who should be contacted for technical issues accessing the full announcement?
For technical issues accessing the full announcement, the listing provides the NIH Office of Extramural Research (OER) webmaster contact: FBOWebmaster@OD.NIH.GOV.
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