Opportunity Information: Apply for PA 14 216
Apply for PA 14 216
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "B Cell Help Immunology Program for AIDS Vaccine Strategies (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on May 12, 2014 and posted on May 12, 2014.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: County governments Native American tribal governments (Federally recognized) Small businesses Special district governments Private institutions of higher education State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public and State controlled institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The B Cell Help Immunology Program for AIDS Vaccine Strategies (R01) grant opportunity (Funding Opportunity Number PA-14-216) was a discretionary National Institutes of Health (NIH) research grant designed to strengthen HIV-1 vaccine development by focusing on how effective antibody responses are created and sustained. The central scientific aim of the program was to support multidisciplinary R01 projects that dig into the immunology behind B cell help, specifically looking at how innate immune signals and T cell responses shape the quality, magnitude, and durability of B cell responses to HIV-1 antigens. In practical terms, the program sought studies that explain why some immune responses generate strong, long-lasting, protective antibodies while others do not, and how those processes could be steered in a more favorable direction for vaccination.
A key emphasis of the FOA was understanding the roles played by innate immunity and T cells in driving B cell outcomes. This includes clarifying how early innate sensing and inflammatory pathways influence downstream adaptive immunity, and how different types of T cell differentiation programs affect B cell activation, germinal center formation, affinity maturation, class switching, and the development of long-term memory. The announcement also highlighted a translational goal: identifying strategies to modulate innate immune mechanisms and T cell differentiation pathways so that B cells receive the right kind of help at the right time, ultimately improving HIV-1 vaccine performance and supporting durable immune memory. In other words, beyond describing immune mechanisms, applicants were expected to propose ways to use that knowledge to optimize vaccine-induced antibody responses.
From an administrative standpoint, the opportunity used the NIH R01 funding instrument and fell under the health-related funding activity category. It was associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), reflecting its placement within the infectious disease and immunology research space. Cost sharing or matching was not required, which aligns with typical NIH R01 policies.
Eligibility was broad and included many types of domestic U.S. applicants such as public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), state and local governments, tribal governments and tribal organizations, special district governments, independent school districts, public housing authorities/Indian housing authorities, and for-profit organizations (including small businesses and other for-profit entities). The FOA also explicitly included additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, Asian American Native American Pacific Islander serving institutions (AANAPISIs), faith-based or community-based organizations, U.S. territories or possessions, eligible federal agencies, and non-U.S. entities (foreign organizations) and regional organizations. That wide eligibility reflects NIH’s interest in attracting diverse teams and capabilities, which is important for the kind of multidisciplinary immunology and vaccine-focused work the FOA was aiming to support.
In terms of timing, the FOA was posted and created on May 12, 2014, with an original and final closing date of January 7, 2017, and it was archived on February 7, 2017. The sponsoring agency was the NIH, and the full announcement was available through the NIH grants guide at the link provided in the source material. For technical access or linking problems, the contact listed was the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
Overall, PA-14-216 was focused on advancing HIV-1 vaccine strategies by funding R01 projects that connect mechanistic immunology (innate pathways and T cell help) to practical approaches for improving B cell helper function, antibody quality, and long-term immune memory after vaccination.
Frequently Asked Questions (FAQs)
What is the B Cell Help Immunology Program for AIDS Vaccine Strategies (R01)?
It is a discretionary National Institutes of Health (NIH) research grant opportunity focused on strengthening HIV-1 vaccine development by improving understanding of how effective antibody responses are created and sustained. The program supported multidisciplinary R01 research projects centered on the immunology of "B cell help."
What is the Funding Opportunity Number (FON) for this grant?
The Funding Opportunity Number is PA-14-216.
What type of grant mechanism does this opportunity use?
This opportunity used the NIH R01 funding instrument.
What scientific problem is this program trying to address?
The program aimed to explain why some immune responses generate strong, long-lasting, protective antibodies while others do not, and how those processes could be steered in a more favorable direction for vaccination against HIV-1.
What is meant by "B cell help" in the context of this FOA?
In this FOA, "B cell help" refers to the immune interactions and signals (especially from innate immunity and T cells) that shape B cell responses to HIV-1 antigens, including the quality, magnitude, and durability of antibody responses.
What are the central scientific aims of PA-14-216?
The central aim was to fund multidisciplinary R01 projects investigating how innate immune signals and T cell responses shape B cell outcomes in response to HIV-1 antigens, with an emphasis on generating and sustaining effective antibody responses.
What specific immune components are emphasized in this funding opportunity?
A key emphasis is understanding the roles of innate immunity and T cells in driving B cell outcomes, including how early innate sensing and inflammatory pathways influence downstream adaptive immunity and how T cell differentiation programs affect B cell responses.
What aspects of B cell biology and antibody development are highlighted?
The announcement highlighted research into B cell activation, germinal center formation, affinity maturation, class switching, and the development of long-term memory, as influenced by innate immune pathways and T cell differentiation programs.
Is this opportunity purely basic science, or does it have a translational focus?
It includes a translational goal. Beyond describing immune mechanisms, applicants were expected to propose strategies to modulate innate immune mechanisms and T cell differentiation pathways so B cells receive the right kind of help at the right time, ultimately improving HIV-1 vaccine performance and durable immune memory.
What does the FOA suggest about modulating immune pathways?
The FOA highlighted identifying strategies to modulate innate immune mechanisms and T cell differentiation pathways to optimize vaccine-induced antibody responses and support durable immune memory.
What funding activity category does this opportunity fall under?
It falls under a health-related funding activity category.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. Cost sharing or matching was not required.
Who is the sponsoring agency for PA-14-216?
The sponsoring agency was the National Institutes of Health (NIH).
When was this FOA created and posted?
It was created and posted on May 12, 2014.
What were the original and final closing dates for this opportunity?
The original and final closing date was January 7, 2017.
When was the FOA archived?
It was archived on February 7, 2017.
Is this grant opportunity still open?
No. Based on the provided information, the FOA has a final closing date of January 7, 2017 and was archived on February 7, 2017.
What types of U.S. organizations were eligible to apply?
Eligibility included a broad range of domestic U.S. applicants such as public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations); state and local governments; tribal governments and tribal organizations; special district governments; independent school districts; public housing authorities/Indian housing authorities; and for-profit organizations (including small businesses and other for-profit entities).
Were for-profit organizations eligible to apply?
Yes. For-profit organizations were eligible, including small businesses and other for-profit entities.
Were tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations were listed as eligible applicants.
Were U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions were explicitly included among additional eligible applicants.
Were non-U.S. (foreign) organizations eligible?
Yes. The FOA explicitly included non-U.S. entities (foreign organizations) and regional organizations as eligible applicants.
Which categories of minority-serving institutions were explicitly included?
The FOA explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribal Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions (AANAPISIs).
Were faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were explicitly listed as eligible applicants.
Were eligible federal agencies included as potential applicants?
Yes. Eligible federal agencies were included among the additional eligible applicants.
What kind of research teams was NIH trying to attract with this FOA?
The FOA emphasized multidisciplinary R01 projects and broad eligibility, reflecting an interest in attracting diverse teams and capabilities relevant to immunology and HIV-1 vaccine-focused research.
Where was the full announcement made available?
The full announcement was available through the NIH grants guide (at the link provided in the source material).
Who is listed as the contact for technical access or linking problems?
The contact listed for technical access or linking problems was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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