Basic Cancer Research in Cancer Health Disparities (R01) | Apply Online

Opportunity Summary:

The National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) titled "Basic Cancer Research in Cancer Health Disparities (R01)" (Funding Opportunity Number PAR-15-093) was a discretionary grant program intended to fund basic, mechanistic studies that dig into the biological and genetic drivers of cancer health disparities. The central purpose was to move beyond describing disparities and instead support research that can explain, at a fundamental level, why certain populations experience different cancer risks, disease characteristics, or outcomes. The FOA emphasized innovative basic research that clarifies mechanisms underlying disparities and helps build a stronger national research community focused on the biology and genetics of cancer inequities.

This opportunity supported R01 research project grants focused on understanding biological factors associated with cancer disparities. NIH highlighted several broad categories of work that would fit well under the announcement. One major area was mechanistic research on biological contributors to disparities, including studies that sit squarely in cancer biology and studies tied to cancer prevention intervention strategies, as long as the work remained grounded in basic or mechanistic questions. A second area was the development and testing of new methods, models, and tools that make it possible to study cancer disparity mechanisms more effectively, such as improved experimental systems, analytical approaches, or model development that better captures relevant population-level biological variation. A third area was secondary data analysis, meaning applicants could propose rigorous analyses of existing datasets to investigate biological or genetic hypotheses related to disparities, rather than collecting entirely new data, provided the work was still aligned with the FOA's mechanistic focus.

A notable goal of PAR-15-093 was capacity-building for the field. NIH framed the FOA as a way to help grow a nationwide cohort of investigators with deep basic-research expertise in cancer health disparities, strengthening the pipeline of scientists who can conduct mechanistic work and expand what the community can study. The announcement explicitly pointed to the importance of expanding and improving resources and tools needed for this type of research, including biospecimens, cell lines, and methods. In practical terms, the FOA was not only about producing individual research findings, but also about leaving behind better infrastructure and more skilled researchers capable of sustaining progress in disparity-focused basic cancer research.

From an administrative standpoint, the opportunity was posted January 16, 2015, with an original and current closing date of November 17, 2017, and it was archived on December 18, 2017. The program fell under the NIH activity category of Health (with Education also listed in the activity category field), and the CFDA listing included 93.393, Cancer Cause and Prevention Research. Cost sharing or matching was not required. The listed award ceiling was $250,000 (as provided in the source data), which signals an expectation about the maximum award amount as presented in this summary, though applicants would typically still need to follow NIH budget rules and the specific FOA instructions in the full announcement.

Eligibility for applicants was broad and included many types of organizations. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and other nonprofits), for-profit organizations (including small businesses and other for-profits), and various government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility language also explicitly included tribal organizations and governments, including federally recognized Native American tribal governments as well as other tribal entities. The FOA also called out additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and even non-U.S. (foreign) entities. Overall, NIH structured eligibility to encourage participation across a wide range of institutions, including those closely connected to populations affected by cancer disparities and those positioned to contribute specialized basic science expertise.

For applicants seeking the official details, NIH provided an additional information link to the full FOA text: http://grants.nih.gov/grants/guide/pa-files/PAR-15-093.html. For access or technical issues related to the online announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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Previous opportunity: Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21)

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