Opportunity Information: Apply for RFA HL 12 015
Apply for RFA HL 12 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Basic Research in Calcific Aortic Valve Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Apr 5, 2011 and posted on Apr 5, 2011.
- Applicants must submit their applications by Oct 11, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Special district governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non U.S.) components of U.S. Organizations are not allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH funding opportunity RFA-HL-12-015, titled "Basic Research in Calcific Aortic Valve Disease (R01)," is a discretionary grant program in the cardiovascular research area (CFDA 93.837) designed to push forward fundamental, mechanism-focused work on calcific aortic valve disease (CAVD). The central goal is to stimulate innovative molecular and physiological studies that clarify how CAVD starts and progresses, and to translate those insights toward two practical endpoints: earlier diagnosis and the development of effective medical (non-surgical) therapies. A key expectation is that every application makes a clear, explicit case for how the proposed basic research could realistically inform early detection strategies or lead to therapeutically actionable approaches for CAVD, rather than remaining purely descriptive or disconnected from clinical impact.
The announcement strongly encourages investigators from adjacent or enabling disciplines to apply, reflecting the idea that CAVD shares biology with other mineralization and tissue remodeling processes. In particular, NIH highlights related areas such as mineralization and bone physiology, extracellular matrix physiology, and molecular imaging. This emphasis signals interest in cross-disciplinary projects that bring in tools, models, and conceptual frameworks that may not be traditional in valve biology but could unlock new ways to measure, predict, or interrupt calcification. Examples of the kinds of directions implied by the FOA include mechanistic studies of calcification pathways, valve interstitial cell behavior, extracellular matrix remodeling, inflammatory or metabolic contributors, signaling networks that regulate osteogenic-like transformation in valve tissue, and imaging or biomarker strategies that could identify disease earlier than current clinical practice.
This opportunity uses the NIH R01 research project grant mechanism, meaning it is intended for substantial, hypothesis-driven projects with a coherent research plan, clear aims, and strong justification for significance and innovation. The estimated total funding level listed for the FOA is $4,000,000, with an award ceiling of $250,000 (as provided in the source data). No cost sharing or matching is required. The FOA was posted on April 5, 2011, with an original and current closing date of October 11, 2011, and an archive date of November 11, 2011, indicating it was a time-limited solicitation rather than an open-ended standing program announcement.
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include public and private institutions of higher education, public and state-controlled institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (other than small businesses, with small businesses also eligible separately), and a wide range of government bodies such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also calls out additional eligible categories including Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal organizations and certain tribal governments, regional organizations, U.S. territories or possessions, faith-based or community-based organizations, and eligible federal agencies. At the same time, non-domestic (non-U.S.) entities are explicitly not eligible to apply, and foreign components of U.S. organizations are not allowed, keeping the work and applicant organizations within domestic boundaries.
Administratively, the sponsoring agency is the National Institutes of Health. The full announcement was hosted through the NIH grants guide at the link provided in the source data (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-12-015.html). For access or technical issues related to the posting, the contact listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), which is a support contact for problems reaching or linking to the announcement rather than a scientific program contact.
In practical terms, the FOA is best read as NIH signaling a need for deeper, more creative basic science aimed at breaking the current clinical bottleneck in CAVD: many patients are diagnosed after substantial valve damage has occurred, and definitive treatment often remains procedural (for example, valve replacement) rather than pharmacologic. By prioritizing research that can plausibly enable earlier detection or identify druggable mechanisms, and by welcoming investigators from mineralization biology, extracellular matrix science, and molecular imaging, the program is structured to broaden the pipeline of ideas and methods that could ultimately produce clinically meaningful advances in how CAVD is found and treated.
Frequently Asked Questions (FAQs): RFA-HL-12-015 - Basic Research in Calcific Aortic Valve Disease (R01)
What is the funding opportunity?
This opportunity is the NIH funding opportunity announcement (FOA) RFA-HL-12-015, titled "Basic Research in Calcific Aortic Valve Disease (R01)." It is a discretionary NIH grant program focused on cardiovascular research (CFDA 93.837) and supports fundamental, mechanism-focused studies on calcific aortic valve disease (CAVD).
What is the main goal of this FOA?
The central goal is to stimulate innovative molecular and physiological research that clarifies how CAVD begins and progresses, and to move those insights toward two practical outcomes: earlier diagnosis and the development of effective medical (non-surgical) therapies.
What does NIH mean by "basic research" in this announcement?
In this FOA, basic research refers to fundamental studies aimed at understanding underlying mechanisms (molecular and physiological) of CAVD, rather than primarily descriptive work. NIH is emphasizing hypothesis-driven, mechanistic projects that can plausibly inform how to detect CAVD earlier or identify actionable therapeutic strategies.
Is clinical impact required even though this is a basic research FOA?
Yes. A key expectation is that each application clearly and explicitly explains how the proposed basic research could realistically inform early detection strategies or support therapeutically actionable approaches for CAVD, rather than remaining disconnected from clinical impact.
What types of research topics are encouraged?
The FOA implies interest in mechanistic directions such as calcification pathways, valve interstitial cell behavior, extracellular matrix remodeling, inflammatory or metabolic contributors, signaling networks that regulate osteogenic-like transformation in valve tissue, and imaging or biomarker strategies that could identify disease earlier than current clinical practice.
Are cross-disciplinary projects encouraged?
Yes. NIH strongly encourages investigators from adjacent or enabling disciplines to apply, based on the idea that CAVD shares biology with other mineralization and tissue remodeling processes.
Which adjacent disciplines does NIH specifically highlight?
NIH highlights related areas including mineralization and bone physiology, extracellular matrix physiology, and molecular imaging. The emphasis suggests interest in projects that bring tools, models, or frameworks that are not traditionally used in valve biology but may enable new ways to measure, predict, or interrupt calcification.
What grant mechanism is used for this opportunity?
This FOA uses the NIH R01 research project grant mechanism, which is intended for substantial, hypothesis-driven projects with a coherent research plan, clear aims, and strong justification for significance and innovation.
How much funding is available under this FOA?
The FOA lists an estimated total funding level of $4,000,000.
Is there an award ceiling?
Yes. The award ceiling is listed as $250,000 (as provided in the source data).
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
When was the FOA posted?
The FOA was posted on April 5, 2011.
What were the closing date and archive date?
The original and current closing date was October 11, 2011, and the archive date was November 11, 2011. This indicates it was a time-limited solicitation rather than an open-ended standing program announcement.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
Where can the full announcement be found?
The full announcement was hosted through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-12-015.html
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include public and private institutions of higher education; public and state-controlled institutions of higher education; nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits); for-profit organizations (other than small businesses, with small businesses also eligible separately); and many government bodies including state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are minority-serving institutions and tribal entities eligible?
Yes. The FOA calls out additional eligible categories including Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), tribal organizations and certain tribal governments, regional organizations, U.S. territories or possessions, faith-based or community-based organizations, and eligible federal agencies.
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities are explicitly not eligible to apply.
Are foreign components of U.S. organizations allowed?
No. Foreign components of U.S. organizations are not allowed, meaning the applicant organizations and the work must remain within domestic boundaries.
What is the CFDA number and program area?
The CFDA number listed is 93.837, and the program area is cardiovascular research.
What is the practical problem NIH is trying to address in CAVD?
The FOA reflects NIH concern that many patients are diagnosed after substantial valve damage has already occurred and that definitive treatment often remains procedural (for example, valve replacement) rather than pharmacologic. The program prioritizes research that can plausibly enable earlier detection or uncover druggable mechanisms.
Does the FOA provide a technical contact for access issues?
Yes. For access or technical issues related to the posting, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV. This is described as a support contact for problems reaching or linking to the announcement, not a scientific program contact.
Browse more opportunities from the same category: Health
Next opportunity: Pulmonary Vascular Right Ventricular Axis Research Program (R01)
Previous opportunity: Anchoring Metabolomic Changes to Phenotype (P20)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA HL 12 015
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA HL 12 015) also looked into and applied for these:
| Funding Opportunity |
|---|
| Pulmonary Vascular Right Ventricular Axis Research Program (R01) Apply for RFA HL 12 021 Funding Number: RFA HL 12 021 Agency: National Institutes of Health Category: Health Funding Amount: $450,000 |
| Short Term Institutional Training Grant for Clinician Scientists in Pediatric Respiratory, Sleep and Hematology/Transfusion Medicine (T35) Apply for RFA HL 12 017 Funding Number: RFA HL 12 017 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pathophysiology of HIV Associated Neurodegeneration in Aging Populations on Long Term Anti Retroviral Therapy (R01) Apply for RFA MH 12 070 Funding Number: RFA MH 12 070 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pathophysiology of HIV Associated Neurodegeneration in Aging Populations on Long Term Anti Retroviral Therapy (R21) Apply for RFA MH 12 071 Funding Number: RFA MH 12 071 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| 2011 Announcement of Availability of Funds for One Cooperative Agreement to Publish Public Health Reports Apply for SG PHR 11 001 Funding Number: SG PHR 11 001 Agency: Office of the Assistant Secretary for Health Category: Health Funding Amount: Case Dependent |
| Planning Grants for Expansion of the Comprehensive Community Mental Health Services for Children and their Families Apply for SM 11 008 Funding Number: SM 11 008 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $800,000 |
| Allergen Epitope Research and Validation Cnters (U19) Apply for RFA AI 11 013 Funding Number: RFA AI 11 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition The Health and Retirement Study (U01) Apply for RFA AG 12 001 Funding Number: RFA AG 12 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Global Health Fellows Program II (GHFP II) Apply for SOL OAA 11 000042 Funding Number: SOL OAA 11 000042 Agency: Agency for International Development Category: Health Funding Amount: $220,000,000 |
| Improving Child and Maternal Nutrition in Tanzania Apply for USAID TANZAIA 11 005 RFA Funding Number: USAID TANZAIA 11 005 RFA Agency: Tanzania USAID Dar es Salaam Category: Health Funding Amount: $35,000,000 |
| Life After Linkage The Future of Family Studies (R01) Apply for RFA HL 12 007 Funding Number: RFA HL 12 007 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| Understanding Clinical Information Needs and Health Care Decision Making Processes in the Context of Health Information Technology (IT) (R01) Apply for PA 11 198 Funding Number: PA 11 198 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $500,000 |
| Academic Career Award (Parent K07) Apply for PA 11 192 Funding Number: PA 11 192 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Public Health Surveillance for the Prevention of Complications of Bleeding and Clotting Disorders Apply for CDC RFA DD11 1103 Funding Number: CDC RFA DD11 1103 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Understanding User Needs and Context to Inform Consumer Health Information Technology (IT) Design (R01) Apply for PA 11 199 Funding Number: PA 11 199 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: $500,000 |
| Services Grant Program for Residential Treatment for Pregnant and Postpartum Women Apply for TI 11 009 Funding Number: TI 11 009 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $524,000 |
| Grants to Enhance Older Adult Behavioral Health Services Apply for SM 11 009 Funding Number: SM 11 009 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $356,344 |
| Cooperative Agreement for the Drug Demand Reduction Initiative for Iraq Apply for TI 11 011 Funding Number: TI 11 011 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $770,000 |
| Service Area Competition Additional Areas Apply for HRSA 11 178 Funding Number: HRSA 11 178 Agency: Health Resources and Services Administration Category: Health Funding Amount: $1,072,582 |
| NIMHD Health Disparities Research (R01) Apply for RFA MD 12 001 Funding Number: RFA MD 12 001 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA HL 12 015", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.