Opportunity Information: Apply for PA 09 152
Apply for PA 09 152
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Basic Research on HIV Persistence (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Apr 8, 2009 and posted on Apr 8, 2009.
- Applicants must submit their applications by Jan 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) State governments Public and State controlled institutions of higher education Small businesses City or township governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Basic Research on HIV Persistence (R01) opportunity (Funding Opportunity Number PA-09-152) is a National Institutes of Health (NIH) grant announcement from the National Institute of Allergy and Infectious Diseases (NIAID) focused on one central problem: why HIV-1 persists in people even when they are taking highly active antiretroviral therapy (HAART) and standard blood tests show the virus is suppressed. The program is designed to fund hypothesis-driven basic research that digs into the underlying biology of HIV persistence, including the viral and host mechanisms that allow residual infection to remain despite effective treatment. The larger goal is to generate foundational knowledge that can later be translated into therapeutic strategies aimed at either long-term remission without ongoing therapy (sometimes described as a functional cure) or complete eradication of remaining virus and a complete cure.
A key emphasis of the announcement is encouraging new ideas, creative approaches, and enabling technologies that can move the field forward. This includes the development and improvement of experimental models and assays specifically suited to studying persistence, latency, and residual reservoirs in the setting of suppressive therapy. In practical terms, applicants are expected to propose rigorous basic science that directly addresses questions like where persistent virus is maintained, how infected cells survive, what signals keep HIV transcriptionally silent or intermittently active, and how immune responses and tissue environments influence the stability of viral reservoirs. The FOA frames this as an early step in a broader, multi-stage research effort: first understand the basic mechanisms of persistence, then use that knowledge to develop ways to control or eliminate the cells that carry the virus.
Funding is offered through the NIH Research Project Grant (R01) mechanism, meaning it supports discrete, investigator-initiated research projects with defined aims and milestones typical of NIH R01 applications. The announcement does not set a fixed award size, project period, or a specific number of grants to be made. Instead, NIAID indicates that budget amounts and durations will vary depending on the scope of each proposed project, and that the final number of awards and total dollars committed will depend on the volume of applications received, their scientific quality, the length of the proposed work, and the requested costs.
In terms of who can apply, eligibility is broad and includes many types of organizations across the public, private, nonprofit, and academic sectors. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (other than small businesses, though small businesses are also listed as eligible), state and local governments (including counties, cities or townships, and special district governments), independent school districts, public housing authorities/Indian housing authorities, and tribal governments and organizations (both federally recognized and other tribal entities). The eligibility list also explicitly includes groups and institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, U.S. territories or possessions, and non-U.S. (foreign) organizations and regional organizations. The FOA also specifies that there is no cost-sharing or matching requirement.
Administratively, the opportunity was posted on April 8, 2009, with an original and current closing date listed as January 7, 2012, and an archive date of February 7, 2012, indicating it is no longer open but remains available as a record of the solicitation. The associated CFDA number is 93.856 (Microbiology and Infectious Diseases Research), and the activity category is Health. The full announcement was made available through the NIH grants guide (link provided in the source text), with NIH Office of Extramural Research (OER) webmaster contacts included for technical access issues.
Overall, this FOA is best understood as a targeted R01 call meant to strengthen the scientific foundation needed to ultimately reach HIV remission and cure goals. It prioritizes fundamental, mechanism-oriented studies of HIV-1 persistence under suppressive therapy, and it encourages applicants to bring forward innovative models, assays, and conceptual frameworks that can clarify how reservoirs are established and maintained and, in turn, inform future therapeutic strategies aimed at durable remission or eradication.
FAQs: Basic Research on HIV Persistence (R01) - PA-09-152
What is the Basic Research on HIV Persistence (R01) opportunity?
It is a National Institutes of Health (NIH) funding opportunity announcement focused on basic, hypothesis-driven research to understand why HIV-1 persists in people even when they are taking highly active antiretroviral therapy (HAART) and standard blood tests show the virus is suppressed.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-09-152.
Which NIH institute is associated with this opportunity?
The announcement is from the National Institute of Allergy and Infectious Diseases (NIAID) within NIH.
What grant mechanism does this opportunity use?
Funding is offered through the NIH Research Project Grant (R01) mechanism, which supports discrete, investigator-initiated research projects with defined aims and typical R01 milestones.
What is the central scientific problem this FOA is trying to address?
The FOA targets the question of why HIV-1 remains in the body despite effective HAART, even when standard blood tests indicate viral suppression.
What is meant by HIV persistence in the context of suppressive therapy?
In this FOA, persistence refers to residual infection that remains in people on effective treatment, including latent or reservoir-based infection that is not eliminated even when circulating virus appears suppressed by standard testing.
What kinds of research does the FOA prioritize?
It prioritizes hypothesis-driven basic research aimed at understanding the viral and host mechanisms that allow HIV to persist under suppressive therapy.
Is the focus on basic research or clinical trials?
The focus described in the opportunity is on basic, mechanism-oriented research designed to generate foundational knowledge about persistence, latency, and reservoirs.
What are examples of the scientific questions applicants are expected to address?
The FOA highlights questions such as where persistent virus is maintained, how infected cells survive, what signals keep HIV transcriptionally silent or intermittently active, and how immune responses and tissue environments influence the stability of viral reservoirs.
Does the FOA encourage development of models or assays?
Yes. A key emphasis is on new ideas, creative approaches, enabling technologies, and the development or improvement of experimental models and assays suited to studying persistence, latency, and residual reservoirs in the setting of suppressive therapy.
What is the longer-term goal of the research supported by this FOA?
The longer-term goal is to generate foundational knowledge that can later be translated into strategies aimed at long-term remission without ongoing therapy (sometimes described as a functional cure) or complete eradication of remaining virus and a complete cure.
How does the FOA describe the role of this research in the broader path toward HIV cure goals?
It is framed as an early step in a broader, multi-stage effort: first understand basic mechanisms of persistence, then use that knowledge to develop ways to control or eliminate the cells that carry the virus.
Does the announcement specify a fixed award size?
No. The announcement does not set a fixed award size.
Does the announcement specify a fixed project period or duration?
No. It does not set a fixed project period, indicating that durations will vary depending on the scope of the proposed project.
Does the announcement specify how many awards will be made?
No. It does not specify a set number of grants to be awarded.
What factors influence the number of awards and total funding committed?
NIAID indicates that awards and total dollars will depend on the volume of applications received, scientific quality, the length of the proposed work, and requested costs.
Is cost sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses, as listed); state and local governments; counties, cities or townships, and special district governments; independent school districts; public housing authorities/Indian housing authorities; tribal governments and organizations (federally recognized and other tribal entities); U.S. territories or possessions; non-U.S. (foreign) organizations; and regional organizations.
Are Historically Black Colleges and Universities (HBCUs) and other minority-serving institutions included?
Yes. The eligibility list explicitly includes HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are faith-based or community-based organizations eligible?
Yes. The announcement explicitly includes faith-based or community-based organizations among eligible applicants.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility list includes non-U.S. (foreign) organizations and regional organizations.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.856, titled Microbiology and Infectious Diseases Research.
What is the activity category for this opportunity?
The activity category is Health.
When was this opportunity posted?
It was posted on April 8, 2009.
What were the closing date and archive date?
The original and current closing date is listed as January 7, 2012, and the archive date is February 7, 2012.
Is this opportunity still open for applications?
No. Based on the listed closing and archive dates, it is no longer open and remains available as an archived record of the solicitation.
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide, as referenced in the opportunity description.
Who is listed for technical access issues related to the announcement?
NIH Office of Extramural Research (OER) webmaster contacts are included for technical access issues.
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