Behavioral and Integrative Treatment Development Program (R34) | Apply Online

Opportunity Summary:

The Behavioral and Integrative Treatment Development Program (R34), Funding Opportunity Number PA-10-013, is a National Institutes of Health grant opportunity designed to push treatment research forward at an early, practical stage. Its central goal is to help researchers build, refine, and test evidence-based interventions before moving on to larger and more expensive clinical studies. In plain terms, this program supports the kind of groundwork that makes later full-scale trials possible: creating or adapting a treatment, turning it into a clear, usable manual or protocol, standardizing how it is delivered, and running early efficacy or pilot work to see whether it is feasible, acceptable to participants, and workable in real-world settings.

The FOA is especially focused on what NIH describes as Stage I treatment development research. That means applicants are generally expected to do early-stage development and pilot testing rather than definitive, large-sample effectiveness trials. The intent is to generate the key evidence needed to justify and design later Stage II or Stage III studies, such as proof that the intervention can be delivered consistently, that participants tolerate it, that recruitment and retention are realistic, and that the approach shows enough promise to warrant a larger trial. The R34 is therefore a bridge between an idea (or an existing intervention that needs adjustment) and a more rigorous, large-scale evaluation.

Scientifically, the opportunity targets behavioral and integrative treatment work within several related domains. One major area is drug abuse and addiction treatment interventions, including behavioral approaches alone as well as combined, sequential, or fully integrated behavioral and pharmacological strategies. The FOA explicitly notes interest in interventions for patients with comorbidities and in diverse settings, signaling that proposals can extend beyond narrowly controlled environments and may address complex clinical realities. A second domain is interventions aimed at preventing HIV acquisition or transmission among individuals in drug abuse treatment, reflecting the close overlap between substance use risk contexts and HIV prevention needs. A third domain emphasizes adherence: projects can focus on improving adherence to drug abuse treatment itself, to HIV-related medications, and to addiction medications, recognizing that even effective treatments fail when people cannot or do not stay engaged. A fourth domain includes interventions to treat chronic pain, an area that intersects with substance use risk, medication management, and behavioral health approaches.

In terms of how the funding is structured, this announcement uses the NIH R34 mechanism, which is commonly used for clinical trial planning or early-stage intervention development and pilot testing. This FOA also runs in parallel with two related announcements that share the same scientific scope but use different grant mechanisms: PA-10-012 under the R01 mechanism (typically for larger, more definitive research projects) and PA-10-011 under the R03 mechanism (often for smaller, more limited studies). That parallel structure matters because it gives applicants options depending on how advanced their intervention is and how much preliminary work has already been completed.

Awards under this FOA are discretionary and dependent on the availability of funds and the quality and quantity of applications received. In other words, NIH is clear that funding is not guaranteed simply because an application is submitted; awards depend on appropriations and on whether enough highly competitive proposals are in the pool. The CFDA listing associated with this program is 93.279 (Drug Abuse and Addiction Research Programs). The opportunity does not require cost sharing or matching funds, which lowers the barrier for many applicants and can be especially important for smaller organizations or community-based research partnerships.

Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include private and public institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and a wide range of governmental entities (state, county, city or township, special district governments, independent school districts, and public housing authorities, including Indian housing authorities). The FOA also highlights additional eligible groups such as faith-based and community-based organizations, federally eligible agencies, and a range of institutions serving specific populations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, tribal governments and tribal organizations, regional organizations, and U.S. territories or possessions. It also allows foreign (non-U.S.) entities to apply, which can be important for cross-national or global health-relevant intervention development, particularly in areas like HIV prevention and treatment adherence.

Administrative details in the source record show that the opportunity was originally posted on October 14, 2009, with a listed closing date of January 7, 2013, and an archive date of February 7, 2013, indicating it is no longer active as a current competition. The full announcement was historically available through the NIH Grants Guide, and the contact listed for access or linking problems is the NIH Office of Extramural Research webmaster (FBOWebmaster@od.nih.gov).

Overall, PA-10-013 is best understood as an NIH pathway for turning a promising behavioral or integrative treatment concept into a well-defined, pilot-tested intervention with enough preliminary evidence to compete for and succeed in later-stage, larger clinical research funding. It prioritizes practical development steps (manuals, standardized delivery, feasibility and acceptability testing) while staying tightly aligned with pressing public health needs in addiction treatment, HIV prevention among people in treatment, adherence to treatment and medications, and chronic pain interventions.

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Previous opportunity: Fiscal Year (FY) 2010 Department of Defense Multidisciplinary Research Program of the University Research Initiative

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