Opportunity Information: Apply for PA 10 255
Apply for PA 10 255
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Behavioral Regulation Mechanisms of Alcohol Dependence and Related Phenotypes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Aug 10, 2010 and posted on Aug 10, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education State governments Small businesses Native American tribal governments (Federally recognized) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Independent school districts County governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Behavioral Regulation Mechanisms of Alcohol Dependence and Related Phenotypes (R01) opportunity (Funding Opportunity Number PA-10-255) is a discretionary NIH grant announcement from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Its central aim is to support research that digs into how behavioral regulation works in the context of alcohol dependence, with a focus on the underlying mechanisms that shape the observable behavioral features of dependence. In practical terms, the announcement is looking for Research Project Grant (R01) applications that can explain why and how regulation of behavior breaks down or changes with alcohol dependence, and how those regulatory processes relate to other closely connected phenotypes (for example, traits or measurable characteristics that tend to co-occur with dependence or help define risk and clinical presentation).
This program uses the R01 mechanism, meaning it is intended for full-scale, hypothesis-driven research projects that can support substantial, multi-year work. The announcement explicitly notes that it runs in parallel with a companion funding opportunity of the same scientific scope that uses the R21 mechanism (PA-10-256). That pairing is important because it signals two entry points for similar topic areas: R01 for more developed, comprehensive projects, and R21 for earlier-stage or more exploratory studies. Applicants whose projects are ready for broader execution, larger samples, or more extensive experimental designs would generally align with the R01 track described here.
On funding levels and award counts, the FOA does not set a fixed budget cap or a guaranteed number of awards. Instead, it emphasizes that award size and duration will vary depending on the proposed science, and that the total number of awards and total dollars will ultimately depend on the mix of applications received, including their quality, scope, proposed timelines, and costs. This is a common NIH approach for program announcements where the science can legitimately range from smaller mechanistic studies to larger, multi-component investigations, and where the institute wants flexibility to fund the strongest portfolio of applications rather than committing to a predetermined number of grants.
From an administrative standpoint, the opportunity is categorized as a grant within the health funding activity area, and it is tied to CFDA number 93.273 (Alcohol Research Programs). It does not require cost sharing or matching, which lowers the barrier to participation for organizations that may not have non-federal funds available to contribute. The FOA was posted and created on August 10, 2010, with an original closing date of September 7, 2013, and it was later archived on October 8, 2013. In other words, it reflects a specific historical solicitation window rather than an open, currently active competition.
Eligibility is broad and includes many organization types typically permitted to apply for NIH research funding. Eligible applicants listed include public and private institutions of higher education, nonprofits with and without 501(c)(3) status (including those outside academia), for-profit organizations (with separate mention of small businesses), and a wide range of government entities such as state governments, counties, cities or townships, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility language also extends to multiple categories of tribal and tribally connected entities, including federally recognized tribal governments and other tribal organizations. The additional eligibility information further highlights the inclusion of Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal agencies, U.S. territories or possessions, and non-U.S. entities (foreign organizations). Taken together, this wide eligibility scope suggests NIAAA was aiming to encourage participation from diverse research settings and communities, including institutions serving populations that may be disproportionately affected by alcohol-related harms.
For applicants needing the official announcement details, the FOA provides an NIH grants webpage link (http://grants.nih.gov/grants/guide/pa-files/PA-10-255.html). It also lists NIH Office of Extramural Research (OER) webmaster contact information for technical difficulties accessing the announcement or resolving linking problems (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "The Behavioral Regulation Mechanisms of Alcohol Dependence and Related Phenotypes (R01)".
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-10-255.
Which agency and institute released this FOA?
This is a discretionary NIH grant announcement from the National Institutes of Health (NIH), specifically the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main purpose or scientific focus of this FOA?
The central aim is to support research on behavioral regulation in the context of alcohol dependence, with an emphasis on the underlying mechanisms that shape the observable behavioral features of dependence.
What kinds of research questions is this FOA trying to support?
It is seeking R01 applications that can explain why and how regulation of behavior breaks down or changes with alcohol dependence, and how those regulatory processes relate to related phenotypes (traits or measurable characteristics that co-occur with dependence or help define risk and clinical presentation).
What grant mechanism does this program use?
This program uses the NIH Research Project Grant (R01) mechanism.
What does it mean that this is an R01 opportunity?
Based on the FOA description, the R01 mechanism is intended for full-scale, hypothesis-driven research projects that can support substantial, multi-year work.
Is there a related or companion funding opportunity?
Yes. The FOA notes it runs in parallel with a companion opportunity of the same scientific scope using the R21 mechanism: PA-10-256.
How is the companion R21 opportunity different from this R01 opportunity?
The FOA frames the pairing as two entry points for similar topic areas: R01 for more developed, comprehensive projects, and R21 for earlier-stage or more exploratory studies.
Is there a fixed budget cap for applications under this FOA?
No. The FOA does not set a fixed budget cap and indicates that award size and duration will vary depending on the proposed science.
Does the FOA guarantee a certain number of awards?
No. It does not guarantee a specific number of awards. The number of awards and total dollars depend on the mix of applications received, including their quality, scope, timelines, and costs.
What funding activity area is this opportunity associated with?
The opportunity is categorized as a grant within the health funding activity area.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.273, labeled Alcohol Research Programs.
Is cost sharing or matching required?
No. The FOA states that it does not require cost sharing or matching.
When was this FOA posted and created?
The FOA was posted and created on August 10, 2010.
What was the original closing date for this opportunity?
The original closing date was September 7, 2013.
Is this funding opportunity still active?
No. The FOA was archived on October 8, 2013, which indicates it reflects a historical solicitation window rather than a currently active competition.
Who is eligible to apply?
Eligibility is broad and includes many types of organizations commonly permitted to apply for NIH research funding. The FOA lists eligible applicants including:
- Public and private institutions of higher education
- Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status
- For-profit organizations (including small businesses)
- Government entities such as state governments, counties, cities or townships, special district governments, independent school districts, and public housing authorities/Indian housing authorities
- Federally recognized tribal governments and other tribal organizations
- U.S. territories or possessions
- Eligible federal agencies
- Non-U.S. entities (foreign organizations)
Are minority-serving or community-based institutions specifically included in eligibility?
Yes. The additional eligibility information highlights inclusion of organizations such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations, among others.
Does the FOA appear intended to encourage applications from diverse research settings and communities?
Yes. The wide eligibility scope suggests NIAAA aimed to encourage participation from diverse research settings and communities, including institutions serving populations that may be disproportionately affected by alcohol-related harms.
Where can applicants find the official FOA text?
The FOA provides an NIH Grants page link: http://grants.nih.gov/grants/guide/pa-files/PA-10-255.html
Who should be contacted for technical problems accessing the announcement link?
For technical difficulties accessing the announcement or resolving linking problems, the FOA lists the NIH Office of Extramural Research (OER) webmaster email: FBOWebmaster@OD.NIH.GOV
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