Opportunity Information: Apply for RFA AI 14 004
Apply for RFA AI 14 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Beyond HAART Innovative Approaches to Cure HIV 1 (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.839 Blood Diseases and Resources Research 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 24, 2014 and posted on Jan 24, 2014.
- Applicants must submit their applications by Jul 28, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $11,250,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- Eligible applicants include: County governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education State governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses City or township governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Beyond HAART Innovative Approaches to Cure HIV-1 (U19) grant opportunity (Funding Opportunity Number RFA-AI-14-004) was a National Institutes of Health (NIH) cooperative agreement aimed at pushing HIV research beyond long-term antiretroviral therapy and toward strategies that could eliminate HIV-1 or achieve a durable cure. The program was built around the idea that curing HIV will require coordinated, multi-disciplinary teams working across traditional boundaries, and that progress would be faster if academic investigators and private-sector partners jointly designed and executed the research. In practical terms, the FOA sought integrated, collaborative projects that combine strong basic and preclinical science with translational steps that move promising concepts toward real-world testing.
Scientifically, the FOA emphasized innovative approaches rather than incremental improvements to existing Highly Active Antiretroviral Therapy (HAART). Priority areas included cell-based therapies, especially those involving hematopoietic stem cells, along with novel gene therapy approaches and non-traditional antiviral strategies. Examples specifically highlighted included the development and delivery of molecular and genetic interventions such as microRNAs (miRNAs), small interfering RNAs (siRNAs), and gene-editing enzymes. The intent was to stimulate work on platforms that could either remove or permanently disable viral reservoirs, render target cells resistant to infection, or otherwise interrupt the virus in ways standard drug regimens cannot.
A key feature of the opportunity was its expectation that applications would not stop at discovery research. Applicants were expected to propose a pipeline that spans basic science and preclinical studies and extends into translational activities, such as proof-of-concept testing in relevant animal models and, where appropriate, early studies involving humans. The emphasis on translational work signaled that NIH was looking for programs capable of generating actionable evidence about feasibility, delivery, safety, and biological impact, not just mechanistic insight. Because this was a U19 cooperative agreement, awardees would typically anticipate substantial NIH involvement during the project period, with NIH staff playing an active role consistent with cooperative agreement mechanisms (for example, through programmatic coordination, milestone discussions, and shared oversight expectations).
The opportunity fell under the broader NIH health research mission and was associated with multiple CFDA numbers reflecting relevant research domains, including allergy and infectious diseases, microbiology and infectious diseases, blood diseases and resources, and mental health research grants (93.855, 93.856, 93.839, and 93.242). The overall estimated total funding amount listed for the initiative was $11,250,000, with an award ceiling of $1,500,000. No cost sharing or matching was required, lowering the barrier for eligible institutions to participate.
Eligibility was broad across U.S.-based organizations and governments, including public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status in the categories listed), for-profit entities (with distinctions noted for small businesses), and various government units (state, local, county, city/township, special district). The FOA also explicitly included several categories of mission-driven institutions and communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), among others. Foreign institutions were not eligible to apply directly, and non-U.S. components of U.S. organizations were not eligible; however, foreign components as defined under NIH policy were allowed, which typically means certain international collaborations could be included when scientifically justified and compliant with NIH rules.
Administratively, the FOA was posted on January 24, 2014, with an original and current closing date of July 28, 2014, and an archive date of August 28, 2014, indicating it is no longer open for submission. The administering agency was NIH, and the full announcement was made available through the NIH Grants Guide at the link provided in the source material. For access or technical issues related to the announcement, the contact listed was the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV).
Overall, this opportunity was structured to fund large, coordinated research programs that unite academic and private-sector strengths to develop and test cutting-edge HIV cure strategies, with an explicit focus on cell therapies, gene-based interventions, and unconventional antiviral modalities, and with a strong expectation of progressing from foundational science into concrete translational proof-of-concept work.
Frequently Asked Questions (FAQs): Beyond HAART Innovative Approaches to Cure HIV-1 (U19) (RFA-AI-14-004)
What is the Beyond HAART Innovative Approaches to Cure HIV-1 (U19) funding opportunity?
This opportunity (Funding Opportunity Number RFA-AI-14-004) was a National Institutes of Health (NIH) cooperative agreement (U19) intended to accelerate research that goes beyond long-term antiretroviral therapy and moves toward strategies that could eliminate HIV-1 or achieve a durable cure.
What was the main goal of the program?
The goal was to support integrated, collaborative research programs designed to develop and test innovative approaches aimed at curing HIV-1, including strategies to remove or permanently disable viral reservoirs, make target cells resistant to infection, or interrupt viral persistence in ways that standard drug regimens cannot.
What does "Beyond HAART" mean in this context?
It means the FOA prioritized approaches that are not incremental improvements to Highly Active Antiretroviral Therapy (HAART). Instead, it emphasized non-traditional, potentially curative strategies such as cell-based therapies, gene-based interventions, and unconventional antiviral modalities.
What type of NIH award mechanism was used?
The award mechanism was a U19 cooperative agreement, which generally indicates substantial NIH involvement during the project period, such as programmatic coordination, milestone discussions, and shared oversight expectations consistent with cooperative agreement mechanisms.
What kinds of research approaches were prioritized?
The FOA emphasized innovative approaches to HIV cure research, with priority areas including cell-based therapies (especially those involving hematopoietic stem cells), novel gene therapy approaches, and non-traditional antiviral strategies.
What specific technology examples were highlighted in the announcement?
Examples specifically highlighted included molecular and genetic interventions such as microRNAs (miRNAs), small interfering RNAs (siRNAs), and gene-editing enzymes, including development and delivery methods for these interventions.
Was the FOA focused only on basic research?
No. A key expectation was that applications would propose a pipeline spanning basic science and preclinical studies and extending into translational activities, including proof-of-concept testing in relevant animal models and, where appropriate, early studies involving humans.
What did NIH mean by "translational activities" for this program?
Based on the description provided, translational activities included moving promising concepts toward real-world testing by generating actionable evidence about feasibility, delivery, safety, and biological impact, not only mechanistic findings.
Did the FOA encourage multi-disciplinary teams and cross-sector partnerships?
Yes. The program was built around the idea that curing HIV will require coordinated, multi-disciplinary teams working across traditional boundaries, and that progress would be faster if academic investigators and private-sector partners jointly designed and executed the research.
What types of projects was NIH seeking?
NIH sought integrated, collaborative projects that combine strong basic and preclinical science with translational steps intended to move promising concepts toward testing in practical settings.
What was the estimated total funding amount for the initiative?
The overall estimated total funding amount listed for the initiative was $11,250,000.
What was the award ceiling?
The award ceiling listed for the opportunity was $1,500,000.
Was cost sharing or matching required?
No. The FOA stated that no cost sharing or matching was required.
Which agency administered this opportunity?
The administering agency was the National Institutes of Health (NIH).
Which CFDA numbers were associated with the opportunity?
The opportunity referenced multiple CFDA numbers reflecting relevant research domains: 93.855, 93.856, 93.839, and 93.242.
Who was eligible to apply?
Eligibility was broad across U.S.-based organizations and governments, including public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status in the categories listed), for-profit entities (with distinctions noted for small businesses), and government units (state, local, county, city/township, special district).
Were minority-serving institutions explicitly included as eligible?
Yes. The FOA explicitly included several mission-driven institutions and communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), among others.
Could foreign institutions apply directly?
No. Foreign institutions were not eligible to apply directly.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations were not eligible under the FOA.
Were any international collaborations allowed?
Yes. The FOA stated that foreign components, as defined under NIH policy, were allowed, which typically means certain international collaborations could be included when scientifically justified and compliant with NIH rules.
When was the FOA posted?
The FOA was posted on January 24, 2014.
What was the application deadline?
The original and current closing date listed was July 28, 2014.
Is this funding opportunity still open?
No. The archive date was August 28, 2014, indicating the opportunity is no longer open for submission.
Where was the full announcement published?
The full announcement was made available through the NIH Grants Guide at the link provided in the source material.
Who was listed as the contact for access or technical issues with the announcement?
The contact listed for access or technical issues was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What kind of outcomes was NIH looking for from funded programs?
The FOA emphasized programs capable of producing actionable evidence related to feasibility, delivery, safety, and biological impact of cure-directed strategies, along with proof-of-concept results in relevant models and, when appropriate, early human studies.
Why did NIH choose a cooperative agreement structure for this program?
As described, the U19 cooperative agreement structure aligns with the program's emphasis on coordinated, multi-disciplinary efforts and the expectation of substantial NIH involvement through coordination and oversight activities during the project period.
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