Opportunity Information: Apply for PA 09 126
Apply for PA 09 126
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Biobehavioral Methods to Improve Outcomes Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.361 Nursing Research 93.399 Cancer Control 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
- This funding opportunity was created on Mar 12, 2009 and posted on Mar 12, 2009.
- Applicants must submit their applications by May 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments County governments Public housing authorities/Indian housing authorities State governments Small businesses For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Biobehavioral Methods to Improve Outcomes Research (R21) opportunity (Funding Opportunity Number PA 09 126) was a National Institutes of Health (NIH) grant program designed to push outcomes research forward by improving the way researchers study, measure, and analyze the combined effects of biological and behavioral factors on health. It was issued collaboratively by several NIH components: the National Institute of Nursing Research (NINR), the National Cancer Institute (NCI), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the NIH Office of Behavioral and Social Sciences Research (OBSSR). The core idea was to encourage research teams to build and test new biobehavioral approaches that can more clearly explain how biology and behavior interact to shape patient outcomes and quality of life, especially in real-world clinical contexts where outcomes research often struggles with complex, messy data.
This was an R21 mechanism, meaning it focused on exploratory and developmental projects rather than large, fully mature research programs. The announcement emphasized innovation in three main areas: research design, measurement, and data analysis. In practice, that meant NIH was looking for proposals that could create or refine study designs capable of capturing dynamic bio-behavior relationships, develop better tools or strategies for measuring relevant biological and behavioral variables, and introduce improved analytic techniques for integrating these different types of data into conclusions that matter for patient care and health outcomes. The FOA explicitly encouraged designs and methods that connect biologic and behavioral variables to outcomes like symptom burden, functioning, adherence, disease progression, recovery, and broader quality-of-life measures.
A major theme was strengthening the link between biobehavioral science and clinical practice. The FOA encouraged scientists to increase collaboration within and across existing core centers, exploratory centers, and training programs by sharing findings and designing joint projects. Rather than routine, siloed teamwork, it called for interdisciplinary efforts that deliberately bridge differences in perspectives, incentives, and methods. The intent was for investigators from different backgrounds to move beyond standard collaborations and work together in more integrated, problem-solving ways to develop research methods that are both creative and efficient, and that can ultimately improve the usefulness of outcomes research for patients, clinicians, and health systems.
Administratively, this opportunity was categorized as a discretionary grant under the Education/Health funding activity area. It did not require cost sharing or matching. The award ceiling listed was $200,000, reflecting the smaller, early-stage nature of R21 projects. The program was posted on March 12, 2009, and the original and final closing date was May 7, 2012, with an archive date of June 7, 2012, meaning it is no longer open for new applications under that specific announcement.
Eligibility was broad and included many types of organizations. Eligible applicants ranged from state, county, city or township governments and special district governments to public housing authorities, independent school districts, public and private institutions of higher education, and a wide set of nonprofit and for-profit entities (including small businesses and other for-profit organizations). It also included Native American tribal governments (both federally recognized and other than federally recognized) and tribal organizations, as well as regionally focused organizations and U.S. territories or possessions. The additional eligibility language also made clear that Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, and non-U.S. entities (foreign organizations) could apply, reflecting NIH interest in diverse institutional participation and, where appropriate, international perspectives.
The FOA aligned with multiple CFDA program areas, indicating the cross-cutting nature of the science it aimed to support. Those included nursing research (93.361), cancer control (93.399), deafness and communication disorders research (93.173), and arthritis, musculoskeletal, and skin diseases research (93.846). Taken together, the funding announcement was essentially a call for rigorous, inventive methodological work that helps the research community better understand and predict health outcomes by integrating biological signals with behavioral and social processes, while also making that science more transferable to clinical decision-making and practical healthcare settings. For full details, NIH directed applicants to the official announcement page (PA 09 126) and provided NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
Frequently Asked Questions (FAQs)
What is the Biobehavioral Methods to Improve Outcomes Research (R21) opportunity (PA-09-126)?
PA-09-126 was a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) for an R21 grant mechanism focused on exploratory and developmental research. Its purpose was to advance outcomes research by improving how researchers study, measure, and analyze the combined effects of biological and behavioral factors on health outcomes and quality of life, particularly in real-world clinical contexts where data can be complex.
Which NIH organizations participated in this FOA?
This FOA was issued collaboratively by multiple NIH components: the National Institute of Nursing Research (NINR), the National Cancer Institute (NCI), the National Institute on Deafness and Other Communication Disorders (NIDCD), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), and the NIH Office of Behavioral and Social Sciences Research (OBSSR).
What type of funding mechanism was used?
The opportunity used the R21 mechanism, which is intended for exploratory and developmental projects rather than large, fully mature research programs.
What was the main goal of the program?
The main goal was to encourage research teams to build and test new biobehavioral approaches that more clearly explain how biology and behavior interact to shape patient outcomes and quality of life. The emphasis was on improving outcomes research methods so conclusions are more useful for patient care and health systems.
What does "biobehavioral" mean in the context of this FOA?
In this FOA, "biobehavioral" refers to approaches that integrate biological factors (such as biological signals or indicators) with behavioral and social processes to better understand and predict health outcomes.
What research areas did the FOA emphasize?
The FOA emphasized innovation in three main areas: research design, measurement, and data analysis. The intent was to support methods that can capture dynamic bio-behavior relationships, improve measurement of relevant variables, and strengthen analytic techniques that integrate biological and behavioral data.
What kinds of study designs were encouraged?
The FOA encouraged study designs capable of capturing dynamic relationships between biological and behavioral variables, especially in real-world clinical contexts where outcomes research often encounters complex, messy data.
What kinds of measurement improvements were within scope?
Within scope were proposals that developed better tools or strategies for measuring biological and behavioral variables relevant to health outcomes and quality of life.
What kinds of data analysis approaches were within scope?
The FOA sought improved analytic techniques that can integrate biological and behavioral data in ways that produce conclusions that matter for patient care and health outcomes.
What health outcomes or endpoints did the FOA connect to biobehavioral variables?
The FOA explicitly encouraged methods that link biologic and behavioral variables to outcomes such as symptom burden, functioning, adherence, disease progression, recovery, and broader quality-of-life measures.
How did the FOA aim to connect research to clinical practice?
A major theme was strengthening the link between biobehavioral science and clinical practice by encouraging research methods that are transferable to clinical decision-making and practical healthcare settings.
Did the FOA encourage interdisciplinary collaboration?
Yes. The FOA called for interdisciplinary efforts that bridge differences in perspectives, incentives, and methods. It encouraged teams to move beyond routine, siloed collaboration and work in integrated, problem-solving ways.
Did the FOA mention collaboration across centers or training programs?
Yes. It encouraged scientists to increase collaboration within and across existing core centers, exploratory centers, and training programs by sharing findings and designing joint projects.
What was the funding activity area?
Administratively, the opportunity was categorized as a discretionary grant under the Education/Health funding activity area.
Was cost sharing or matching required?
No. The FOA stated that it did not require cost sharing or matching.
What was the award ceiling?
The award ceiling listed was $200,000, reflecting the smaller, early-stage nature of R21 projects.
When was the FOA posted?
The program was posted on March 12, 2009.
When did the opportunity close?
The original and final closing date was May 7, 2012. The archive date was June 7, 2012, which indicates it is no longer open for new applications under that specific announcement.
Is this FOA currently accepting applications?
No. Based on the final closing date (May 7, 2012) and archive date (June 7, 2012), PA-09-126 is no longer open for new applications under that announcement.
Who was eligible to apply?
Eligibility was broad. Eligible applicants included various government entities (state, county, city or township governments; special district governments; public housing authorities), independent school districts, public and private institutions of higher education, nonprofit and for-profit entities (including small businesses), tribal governments and tribal organizations, regionally focused organizations, and U.S. territories or possessions.
Could tribal governments and tribal organizations apply?
Yes. The FOA included Native American tribal governments (both federally recognized and other than federally recognized) and tribal organizations among eligible applicants.
Could institutions that serve specific populations apply (for example, HBCUs or Hispanic-serving institutions)?
Yes. The additional eligibility language specifically included Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Were faith-based or community-based organizations eligible?
Yes. The FOA stated that faith-based or community-based organizations could apply.
Could federal agencies apply?
Yes. The FOA indicated that eligible federal agencies could apply.
Could non-U.S. (foreign) organizations apply?
Yes. The FOA stated that non-U.S. entities (foreign organizations) could apply, reflecting interest in diverse participation and, where appropriate, international perspectives.
What CFDA program areas were associated with this FOA?
The FOA aligned with multiple CFDA program areas: nursing research (93.361), cancer control (93.399), deafness and communication disorders research (93.173), and arthritis, musculoskeletal, and skin diseases research (93.846).
Why were multiple CFDA areas listed?
Multiple CFDA areas were listed to reflect the cross-cutting nature of the science the FOA aimed to support, spanning several health domains while focusing on shared methodological needs in outcomes research.
Where could applicants find the official FOA details?
NIH directed applicants to the official announcement page for PA-09-126 for full details.
Who was listed for help with access or linking issues?
The FOA referenced NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues related to the official announcement page.
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