Opportunity Information: Apply for FOA HPW RHDJ 2014 0005
Apply for FOA HPW RHDJ 2014 0005
- The Air Force Research Lab in the science and technology and other research and development sector is offering a public funding opportunity titled "Bioeffects Assessments to Prevent Airman Degradation and for Augmenting Performance (BAPADAP)" and is now available to receive applicants.
- This funding opportunity was created on Dec 9, 2014 and posted on Dec 9, 2014.
- Applicants must submit their applications by Jan 23, 2015 200 PM Eastern Standard Time. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $42,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $42,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Bioeffects Assessments to Prevent Airman Degradation and for Augmenting Performance (BAPADAP) opportunity is an Air Force Research Laboratory (AFRL) research and development program focused on understanding how exposures and biological stressors affect Airmen, and on turning that understanding into practical tools that help prevent performance loss and support mission readiness. The core intent is to fund work that can measure, predict, and ultimately mitigate harmful bioeffects tied to Air Force-relevant environments and materials, while also exploring biology-informed approaches that could help sustain or augment human performance.
The program is organized around three major Air Force topic areas. First, Aerospace Toxicology targets the health and performance impacts of chemical and environmental exposures associated with aviation and operational settings, with an emphasis on identifying risks early and supporting evidence-based prevention. Second, Nanotoxicology and nano-bioeffects addresses the unique biological interactions and potential hazards of nanomaterials, including how particle size, surface chemistry, and exposure route can change toxicity or performance outcomes. Third, Molecular Cognition focuses on the biological underpinnings of cognition and cognitive performance, aiming to understand molecular-level factors that relate to mental function, resilience, fatigue, or other performance-relevant states.
Across those three domains, BAPADAP emphasizes building capability in three technical group areas that translate science into usable assessment and decision tools. One pillar is Predictive PBPK Modeling (physiologically based pharmacokinetic modeling), which is aimed at creating or improving models that can predict absorption, distribution, metabolism, and excretion of substances in the body and link exposure conditions to internal dose and biological effect. Another pillar is Biomarker Discovery and Assay Development, intended to identify measurable biological indicators that correlate with exposure, early biological change, susceptibility, or performance degradation, and then develop assays that can detect those biomarkers reliably. The third pillar, Analytical and Biomarker Discovery Chemistry, supports the chemical measurement and analytical methods needed to find, characterize, and quantify relevant compounds and biological signals, including the discovery-oriented chemistry that often underpins biomarker identification and validation.
From a funding and administrative standpoint, this was issued as a discretionary federal assistance opportunity using a cooperative agreement, which typically means the government expects substantial involvement during the period of performance (for example, technical coordination, milestone reviews, or collaboration with AFRL personnel). The total estimated funding was listed at $42,000,000, with an award ceiling also set at $42,000,000 and an award floor of $0, and the announcement anticipated a single award. There was no cost sharing or matching requirement stated. Eligibility was described as unrestricted, meaning it was open to a wide range of entity types unless additional eligibility clarifications were provided in the full announcement.
Key dates indicate the opportunity was posted on December 9, 2014, with a closing deadline of January 23, 2015 at 2:00 PM Eastern Standard Time, and it was archived on February 22, 2015. The activity category was science and technology and other research and development, consistent with the program's focus on advancing toxicology, nano-bioeffects, cognition-related bioeffects, modeling, and biomarker/analytical capabilities. For applicants who had trouble accessing the full announcement, the point of contact listed was Lee Elwood (r.elwood@us.af.mil).
Frequently Asked Questions (FAQs)
What is the BAPADAP opportunity?
BAPADAP (Bioeffects Assessments to Prevent Airman Degradation and for Augmenting Performance) is an Air Force Research Laboratory (AFRL) research and development program focused on understanding how exposures and biological stressors affect Airmen, and translating that understanding into practical tools to prevent performance loss and support mission readiness.
What is the main goal of the program?
The core intent is to fund work that can measure, predict, and ultimately mitigate harmful bioeffects tied to Air Force-relevant environments and materials, while also exploring biology-informed approaches that could help sustain or augment human performance.
Which organization is running this opportunity?
The opportunity is associated with the Air Force Research Laboratory (AFRL).
What kinds of problems is BAPADAP trying to address?
BAPADAP targets health and performance impacts from exposures and biological stressors relevant to aviation and operational environments. It emphasizes early risk identification, evidence-based prevention, and development of assessment and decision tools that help reduce performance degradation and maintain readiness.
What are the three main Air Force topic areas under BAPADAP?
The program is organized around three major topic areas:
- Aerospace Toxicology - Health and performance impacts of chemical and environmental exposures in aviation and operational settings, with emphasis on early risk identification and prevention.
- Nanotoxicology and nano-bioeffects - Biological interactions and potential hazards of nanomaterials, including how size, surface chemistry, and exposure route influence toxicity or performance outcomes.
- Molecular Cognition - Molecular-level factors related to cognition and cognitive performance, including resilience, fatigue, and other performance-relevant states.
What is meant by "Aerospace Toxicology" in this program?
Aerospace Toxicology within BAPADAP focuses on identifying and understanding the health and performance effects associated with chemical and environmental exposures encountered in aviation and operational contexts, with a strong emphasis on identifying risks early and supporting evidence-based prevention strategies.
What is meant by "Nanotoxicology and nano-bioeffects" in this program?
This area addresses how nanomaterials interact with biology and what hazards may arise from those interactions. BAPADAP highlights that toxicity or performance outcomes may depend on nanomaterial properties (such as particle size and surface chemistry) and on the route of exposure.
What is meant by "Molecular Cognition" in this program?
Molecular Cognition focuses on the biological underpinnings of cognition and cognitive performance. It aims to understand molecular-level contributors to mental function and performance-relevant conditions such as resilience and fatigue.
Beyond the three topic areas, what technical capability areas does BAPADAP emphasize?
Across the three domains, BAPADAP emphasizes building capability in three technical group areas intended to translate science into usable assessment and decision tools:
- Predictive PBPK Modeling (physiologically based pharmacokinetic modeling)
- Biomarker Discovery and Assay Development
- Analytical and Biomarker Discovery Chemistry
What is Predictive PBPK Modeling in the context of this opportunity?
Predictive PBPK Modeling (physiologically based pharmacokinetic modeling) is aimed at creating or improving models that predict absorption, distribution, metabolism, and excretion of substances in the body. The intent is to link exposure conditions to internal dose and biological effect.
What does Biomarker Discovery and Assay Development cover?
This pillar is intended to identify measurable biological indicators that correlate with exposure, early biological change, susceptibility, or performance degradation, and to develop assays that can detect those biomarkers reliably.
What does Analytical and Biomarker Discovery Chemistry include?
This area supports the chemical measurement and analytical methods needed to find, characterize, and quantify relevant compounds and biological signals. It also includes discovery-oriented chemistry that can underpin biomarker identification and validation.
What type of funding instrument was used for this opportunity?
The opportunity was issued as a discretionary federal assistance opportunity using a cooperative agreement.
What does a cooperative agreement imply for how the project may be managed?
A cooperative agreement typically means the government expects substantial involvement during the period of performance, such as technical coordination, milestone reviews, or collaboration with AFRL personnel.
How much total funding was estimated for this opportunity?
The total estimated funding amount listed was $42,000,000.
What were the award ceiling and award floor?
The award ceiling was listed as $42,000,000, and the award floor was listed as $0.
How many awards were anticipated?
The announcement anticipated a single award.
Was cost sharing or matching required?
No cost sharing or matching requirement was stated in the information provided.
Who was eligible to apply?
Eligibility was described as unrestricted, meaning it was open to a wide range of entity types unless additional eligibility clarifications were provided in the full announcement.
What was the activity category for this opportunity?
The activity category was science and technology and other research and development, consistent with the program focus on toxicology, nano-bioeffects, cognition-related bioeffects, modeling, and biomarker/analytical capabilities.
When was the opportunity posted?
The opportunity was posted on December 9, 2014.
What was the application deadline?
The closing deadline was January 23, 2015 at 2:00 PM Eastern Standard Time (EST).
What does it mean that the opportunity was archived?
The listing was marked as archived on February 22, 2015.
Who is the point of contact for issues accessing the full announcement?
The point of contact listed for applicants who had trouble accessing the full announcement was Lee Elwood at r.elwood@us.af.mil.
What kinds of deliverables or outcomes is BAPADAP trying to produce?
Based on the description provided, the program is oriented toward practical tools and capabilities that can measure, predict, and mitigate harmful bioeffects, including models (such as PBPK models), biomarkers and reliable assays, and analytical chemistry methods that support discovery and quantification of relevant biological and chemical signals.
Is the program focused only on preventing degradation, or also on improving performance?
It includes both: preventing performance loss and degradation is a central focus, and it also mentions exploring biology-informed approaches that could help sustain or augment human performance.
Is the program limited to one scientific discipline?
No. The scope spans aerospace toxicology, nanotoxicology/nano-bioeffects, and molecular cognition, and it emphasizes cross-cutting technical capabilities like PBPK modeling, biomarker discovery and assay development, and analytical chemistry methods.
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