Opportunity Information: Apply for PA 09 192
Apply for PA 09 192
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Bioenergetics, Fatigability, and Activity Limitations in Aging (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Jun 3, 2009 and posted on Jun 3, 2009.
- Applicants must submit their applications by Sep 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Public housing authorities/Indian housing authorities Small businesses For profit organizations other than small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) County governments Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Bioenergetics, Fatigability, and Activity Limitations in Aging (R03) opportunity (Funding Opportunity Number PA-09-192) is an NIH discretionary grant announcement led by the National Institute on Aging (NIA) in partnership with the Office of Dietary Supplements. It uses the NIH Small Research Grant (R03) mechanism, which is designed for smaller, focused projects that can be completed relatively quickly and with limited resources. In practical terms, this mechanism is intended to fund things like pilot or feasibility studies, secondary analyses of existing datasets, small self-contained research projects, and the development or refinement of research methods or technologies.
The scientific focus is on understanding why older adults experience increased fatigability and how that fatigability contributes to real-world activity limitations, including both physical and cognitive activity. The announcement highlights fatigability as a major driver of restricted engagement in daily life among older adults, which can cascade into poorer function and quality of life. The core premise is that age-related changes in bioenergetics, meaning how the body produces, uses, and regulates energy, may be a key biological contributor to higher fatigability. Applications are therefore expected to connect measurable bioenergetic processes to fatigability outcomes and downstream activity limitations.
The FOA encourages three main types of projects. First, it invites studies that pinpoint specific bioenergetic alterations associated with increased fatigability and limitations in activity, for example, changes in energy metabolism pathways or regulation that could plausibly make routine tasks feel more effortful. Second, it encourages the creation and testing of improved measures of fatigability that are explicitly tied to bioenergetic mechanisms, which could include better assessments, metrics, or methodological tools that more accurately capture fatigability in relation to energy production and utilization. Third, it supports research evaluating interventions aimed at reducing fatigability and activity limitations by targeting bioenergetic alterations, with an emphasis on interventions that can translate into meaningful improvements in quality of life. The involvement of the Office of Dietary Supplements also signals openness to projects where dietary supplements or nutrition-related approaches are relevant, as long as they are grounded in the bioenergetics-fatigability link described in the announcement.
Administratively, this is a health-focused grant under CFDA 93.866 (Aging Research) and it does not require cost sharing or matching. The FOA ran with a posted and created date of June 3, 2009, and it originally closed on September 7, 2012, with an archive date of October 8, 2012, meaning it is no longer accepting applications but remains useful as a reference point for the kinds of projects NIH sought in this area. The announcement also notes that it is part of a set of parallel funding opportunities with the same scientific scope offered through other NIH mechanisms: an R01 version (PA-09-190) for larger, full-scale projects and an R21 version (PA-09-191) for exploratory or developmental work.
Eligibility is broad and includes many organization types across government, academia, nonprofit, and private sectors. Eligible applicants listed include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, state and local governments (including county and city/township governments), independent school districts, special district governments, public housing authorities/Indian housing authorities, tribal governments and tribal organizations, small businesses and other for-profit organizations, and additional categories such as faith-based or community-based organizations, U.S. territories or possessions, and certain minority-serving institutions (including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities). It also explicitly allows non-domestic (non-U.S.) entities (foreign organizations) and regional organizations, which is notable for applicants considering international collaborations or non-U.S.-based research entities.
The full announcement was hosted through the NIH grants guide at the listed link (http://grants.nih.gov/grants/guide/pa-files/PA-09-192.html), and the contact listed for access or linking issues is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the Bioenergetics, Fatigability, and Activity Limitations in Aging (R03) opportunity?
This opportunity (Funding Opportunity Number PA-09-192) is an NIH discretionary grant announcement focused on research that connects age-related bioenergetic changes to increased fatigability in older adults and the resulting limitations in real-world activity (including physical and cognitive activity).
Which NIH institute leads this funding opportunity?
The announcement is led by the National Institute on Aging (NIA), in partnership with the NIH Office of Dietary Supplements.
What grant mechanism does this opportunity use?
It uses the NIH Small Research Grant (R03) mechanism, which is intended for smaller, focused projects that can be completed relatively quickly and with limited resources.
What kinds of projects are typically suitable for an NIH R03?
As described in the opportunity, the R03 mechanism is commonly used for pilot or feasibility studies, secondary analyses of existing datasets, small self-contained research projects, and development or refinement of research methods or technologies.
What scientific problem is this FOA trying to address?
The scientific focus is on understanding why older adults experience increased fatigability and how that fatigability contributes to activity limitations in daily life. The FOA highlights fatigability as a key driver of reduced engagement that can lead to poorer function and quality of life.
What does "bioenergetics" mean in the context of this announcement?
In this FOA, bioenergetics refers to how the body produces, uses, and regulates energy. The core premise is that age-related changes in these energy-related processes may be a biological contributor to increased fatigability.
What is the central premise applicants are expected to address?
Applications are expected to connect measurable bioenergetic processes to fatigability outcomes and to downstream activity limitations, aligning bioenergetic mechanisms with real-world functional impacts.
What types of research projects does the FOA encourage?
The FOA encourages three main categories of projects: (1) studies identifying specific bioenergetic alterations associated with increased fatigability and activity limitations, (2) development and testing of improved measures of fatigability that are explicitly tied to bioenergetic mechanisms, and (3) evaluation of interventions that aim to reduce fatigability and activity limitations by targeting bioenergetic alterations.
What are examples of the first category: identifying bioenergetic alterations?
The announcement points to work that pinpoints specific alterations in energy metabolism pathways or energy regulation that could plausibly make routine tasks feel more effortful and contribute to increased fatigability and limitation.
What does it mean to develop "improved measures" of fatigability for this FOA?
It refers to creating and testing assessments, metrics, or methodological tools that more accurately capture fatigability in a way that is explicitly linked to bioenergetic mechanisms (energy production and utilization), rather than measuring fatigability in isolation.
What types of interventions are in scope under this FOA?
Research evaluating interventions designed to reduce fatigability and related activity limitations by targeting bioenergetic alterations is encouraged, particularly when interventions can translate into meaningful improvements in quality of life.
Does the FOA allow dietary supplement or nutrition-related research?
The involvement of the Office of Dietary Supplements signals openness to projects where dietary supplements or nutrition-related approaches are relevant, as long as the work is grounded in the bioenergetics-fatigability link described in the announcement.
Is this opportunity still accepting applications?
No. The FOA was posted/created on June 3, 2009, and it originally closed on September 7, 2012. It was archived on October 8, 2012, which indicates it is no longer accepting applications (though it remains useful as a reference for the types of projects NIH sought).
What is the CFDA number and program area associated with this opportunity?
This is a health-focused grant under CFDA 93.866 (Aging Research).
Is cost sharing or matching required?
No. The opportunity states that it does not require cost sharing or matching.
Are there related NIH opportunities with the same scientific scope but different mechanisms?
Yes. The announcement notes parallel funding opportunities with the same scientific scope offered through other mechanisms: an R01 version (PA-09-190) and an R21 version (PA-09-191).
What is the purpose of the R01 and R21 versions mentioned?
The FOA describes the R01 (PA-09-190) as the mechanism for larger, full-scale projects, and the R21 (PA-09-191) as the mechanism for exploratory or developmental work, while this FOA uses the smaller R03 mechanism.
Who is eligible to apply?
Eligibility is broad and includes many organization types across government, academia, nonprofit, and private sectors, as listed in the opportunity.
What higher education institutions are eligible?
Public and private institutions of higher education are eligible applicants.
Are nonprofit organizations eligible, and do they need 501(c)(3) status?
Nonprofits are eligible both with and without 501(c)(3) status.
What government entities are eligible?
Eligible applicants include state governments, local governments, county governments, and city or township governments. The list also includes special district governments and independent school districts.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicant types.
Are tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations are explicitly included among eligible applicants.
Are small businesses or for-profit organizations eligible?
Yes. Small businesses and other for-profit organizations are included in the eligible applicant categories.
Are faith-based or community-based organizations eligible?
Yes. The eligibility list includes faith-based and community-based organizations.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are included among the eligible applicant categories.
Are minority-serving institutions eligible?
Yes. The eligibility list includes multiple minority-serving institution categories, including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
Can non-U.S. (foreign) organizations apply?
Yes. The FOA explicitly allows non-domestic (non-U.S.) entities (foreign organizations) and regional organizations.
Where can the full FOA text be found?
The full announcement was hosted through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-09-192.html
Who should be contacted for access or linking issues with the FOA page?
The contact listed for access or linking issues is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What does it mean that this is an NIH "discretionary" grant announcement?
The opportunity is described as an NIH discretionary grant announcement, meaning it is an NIH-issued funding announcement that outlines NIH priorities and the kinds of projects NIH sought to support under this topic using the R03 mechanism.
What outcomes or impacts are emphasized by the FOA?
The FOA emphasizes linking bioenergetic mechanisms to fatigability and then to real-world activity limitations, with attention to how these limitations restrict daily engagement and can lead to poorer function and reduced quality of life in older adults.
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