Bioengineering Research Grants (BRG) (R01) | Apply Online

Opportunity Summary:

The Bioengineering Research Grants (BRG) (R01) opportunity (Funding Opportunity Number PAR-13-137) is a National Institutes of Health (NIH) discretionary grant program designed to push biomedical research forward by bringing life scientists and physical scientists together on the same, clearly defined biomedical problem. The central idea is to fund small, collaborative teams that use a genuinely multidisciplinary bioengineering approach, not just parallel efforts, to produce solutions that are practical, testable, and likely to be adopted by the broader research or clinical community. Projects can sit anywhere along the spectrum from basic to translational to clinical science, as long as the work is integrative and aims to solve a real biological, clinical, or translational bottleneck.

A key emphasis of this announcement is moving promising tools, methods, or techniques from “interesting concept” to “usable solution.” That can include integrating components into a cohesive system, optimizing performance so the method is reliable and reproducible, validating it in relevant models or settings, translating it toward real-world use, or otherwise accelerating adoption for a specific research or clinical application. In other words, this mechanism is well-suited for proposals that can show how engineering-style development and rigorous evaluation will make a tangible difference for a defined problem, rather than simply introducing a new device or method without a clear pathway to uptake.

The program is flexible in the kinds of scientific approaches it will support. Applications may be design-directed (engineering a solution toward a target need), developmental (building and refining a capability), discovery-driven (using engineering approaches to uncover new biology), or hypothesis-driven (testing a focused scientific hypothesis using bioengineering strategies). What ties these together is the expectation that the project benefits from crossing disciplines and that the team can demonstrate an integrative plan where engineering and biomedical questions inform each other in a tight loop, producing outcomes that improve understanding and/or solve practical problems in biomedical research or practice.

Administratively, this is an R01 grant, which typically supports investigator-initiated research projects with defined aims and a multi-year plan, and it is categorized as a grant funding instrument under NIH. The opportunity listed no cost sharing or matching requirement. The announcement was posted March 8, 2013, with a creation date of March 14, 2014, and it had an original and final closing date of May 7, 2016, after which it was archived (archive date June 7, 2016). While the specific posting is archived, the summary still captures how NIH framed these bioengineering collaboration priorities under this FOA.

Eligibility is broad and includes many types of organizations that commonly apply for NIH research funding. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities (state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities). Tribal eligibility is explicitly included, covering federally recognized Native American tribal governments and other tribal organizations, as well as tribally controlled colleges and universities (TCCUs). The announcement also notes eligibility for U.S. territories or possessions and non-U.S. entities (foreign organizations), as well as regional organizations and eligible federal agencies. It additionally calls out several institution types often highlighted in federal programs, such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations where applicable.

In terms of NIH mission alignment, the program spans a wide set of biomedical domains, reflected in the many CFDA numbers associated with it. These include areas such as environmental health, oral diseases and disorders, human genome research, deafness and communication disorders, drug abuse and addiction, technological innovations to improve human health, multiple cancer research areas (from cause and prevention through detection, treatment, biology, and control), cardiovascular research, arthritis and musculoskeletal/skin diseases, neurosciences and neurological disorders, microbiology and infectious diseases, general biomedical research and research training, child health and human development, and vision research. Practically, this breadth signals that strong bioengineering proposals could be relevant across many NIH institutes and centers, as long as they meet the core requirement: a multidisciplinary bioengineering collaboration aimed at producing a validated, adoptable solution to a specific biomedical problem.

For applicants looking for the official archived announcement text and details, NIH provided an Additional Information link at http://grants.nih.gov/grants/guide/pa-files/PAR-13-137.html and listed NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues (FBOWebmaster@OD.NIH.GOV).

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